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The overarching goals of our research program are to investigate novel factors required for herpesvirus infectivity and determine mechanisms of these factors mediating viral infectivity, with the goal of identifying new druggable targets.Â
The overarching goals of our research program are to investigate novel factors required for herpesvirus infectivity and determine mechanisms of these factors mediating viral infectivity, with the goal of identifying new druggable targets.Â
We have identified a host-protein, stem-loop binding protein (SLBP), that is required for human cytomegalovirus (HCMV, a betaherpesvirus) infectivity (Albright and Morrison et al, PNAS, 2022). The goals of the Morrison Lab are to understand what this conserved protein is doing differently in the context of herpesvirus infection compared to standard cellular conditions, how HCMV modulates SLBP to perform a pro-viral function and defining where and how infection with SLBP-knockdown (KD)-derived-HCMV goes wrong in a newly infected cell. Additionally, we plan to investigate whether SLBP has any other yet undiscovered infection-specific functions for other viral infections.
We have identified a host-protein, stem-loop binding protein (SLBP), that is required for human cytomegalovirus (HCMV, a betaherpesvirus) infectivity (Albright and Morrison et al, PNAS, 2022). The goals of the Morrison Lab are to understand what this conserved protein is doing differently in the context of herpesvirus infection compared to standard cellular conditions, how HCMV modulates SLBP to perform a pro-viral function and defining where and how infection with SLBP-knockdown (KD)-derived-HCMV goes wrong in a newly infected cell. Additionally, we plan to investigate whether SLBP has any other yet undiscovered infection-specific functions for other viral infections.
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