Patents & Publications
Patents & Publications
Patents:
Biased NMDA Receptor Modulators and uses thereof. PCT/US2019/061308. Role: Inventor
https://patents.google.com/patent/WO2020102443A1/en
Novel positive and negative allosteric aromatic ring modulators for composition of matter and methods of use. International publication number: WO2012/019106. Role: Co-inventor
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2012019106
Publications:
Costa BM, Hines D, Phillip N, Boehringer SC, Anandakrishnan R, Council-Troche M, Davis JL. Preliminary pharmacokinetics and in vivo studies indicate analgesic and stress mitigation effects of a novel NMDA receptor modulator. J Pharmacol Exp Ther. 2025 Feb 27;392(4):103401. doi: 10.1016/j.jpet.2025.103401. [Epub ahead of print] PubMed PMID: 40086100
Boehringer SC, Johnston TV, Kwapisz LC, VandeVord PJ, Costa BM. CNS4 causes subtype-specific changes in agonist efficacy and reversal potential of permeant cations in NMDA receptors. Pharmacol Res Perspect. 2023 Jun;11(3):e01107. doi: 10.1002/prp2.1107. PubMed PMID: 37283007; PubMed Central PMCID: PMC10245146
Anandakrishnan R, Tobey H, Nguyen S, Sandoval O, Klein BG, Costa BM. Cranial manipulation affects cholinergic pathway gene expression in aged rats. J Osteopath Med. 2022 Jan 10;122(2):95-103. doi: 10.1515/jom-2021-0183. PubMed PMID: 34995434.
France G, Volianskis R, Ingram R, Bannister N, Rothärmel R, Irvine MW, Fang G, Burnell ES, Sapkota K, Costa BM, Chopra DA, Dravid SM, Michael-Titus AT, Monaghan DT, Georgiou J, Bortolotto ZA, Jane DE, Collingridge GL, Volianskis A. Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators. Neuropharmacology. 2022 Jan 1;202:108840. doi: 10.1016/j.neuropharm.2021.108840. Epub 2021 Oct 20. PubMed PMID: 34678377; PubMed Central PMCID: PMC8803579
Costa BM. NMDA receptor modulation and severe acute respiratory syndrome treatment. F1000Res. 2021;10. doi: 10.12688/f1000research.73897.1. eCollection 2021. PubMed PMID: 36544563; PubMed Central PMCID: PMC9745209
Costa BM, Kwapisz LC, Mehrkens B, Bledsoe DN, Vacca BN, Johnston TV, Razzaq R, Manickam D, Klein BG. A glutamate concentration-biased allosteric modulator potentiates NMDA-induced ion influx in neurons. Pharmacol Res Perspect. 2021 Oct;9(5):e00859. doi: 10.1002/prp2.859. PubMed PMID: 34476911; PubMed Central PMCID: PMC8413904
Tobey H, Lucas T, Paul S, Berr SS, Mehrkens B, Brolinson PG, Klein BG, Costa BM. Mechanoceutics Alters Alzheimer's Disease Phenotypes in Transgenic Rats: A Pilot Study. J Alzheimers Dis. 2020;74(2):421-427. doi: 10.3233/JAD-191071. PubMed PMID: 32039851; NIHMSID:NIHMS1736928. NIHMS ID: NIHMS1736928 [Edit Status]
Tobey H, Lucas T, Bledsoe D, Mykins M, Campbell C, Berr SS, Sasser T, Helm R, Brolinson PG, Klein BG, Costa BM. Effect of Osteopathic Cranial Manipulative Medicine on an Aged Rat Model of Alzheimer Disease. J Am Osteopath Assoc. 2019 Oct 15;. doi: 10.7556/jaoa.2019.121. [Epub ahead of print] PubMed PMID: 31613309; PubMed Central PMCID: PMC8425714
Irvine MW, Fang G, Sapkota K, Burnell ES, Volianskis A, Costa BM, Culley G, Collingridge GL, Monaghan DT, Jane DE. Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid. Eur J Med Chem. 2019 Feb 15;164:471-498. doi: 10.1016/j.ejmech.2018.12.054. Epub 2018 Dec 28. Review. PubMed PMID: 30622023; PubMed Central PMCID: PMC7043280
Bledsoe D, Vacca B, Laube B, Klein BG, Costa B. Ligand binding domain interface: A tipping point for pharmacological agents binding with GluN1/2A subunit containing NMDA receptors. Eur J Pharmacol. 2019 Feb 5;844:216-224. doi: 10.1016/j.ejphar.2018.12.023. Epub 2018 Dec 13. PubMed PMID: 30553788.
Bledsoe D, Tamer C, Mesic I, Madry C, Klein BG, Laube B, Costa BM. Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity. Front Pharmacol. 2017;8:229. doi: 10.3389/fphar.2017.00229. eCollection 2017. PubMed PMID: 28536523; PubMed Central PMCID: PMC5423295
Kane LT, Costa BM. Identification of novel allosteric modulator binding sites in NMDA receptors: A molecular modeling study. J Mol Graph Model. 2015 Sep;61:204-13. doi: 10.1016/j.jmgm.2015.06.007. Epub 2015 Aug 4. PubMed PMID: 26280688.
Irvine MW, Fang G, Eaves R, Mayo-Martin MB, Burnell ES, Costa BM, Culley GR, Volianskis A, Collingridge GL, Monaghan DT, Jane DE. Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators. Synthesis (Stuttg). 2015 Jun 1;47(11):1593-1610. doi: 10.1055/s-0034-1380114. PubMed PMID: 26568642; PubMed Central PMCID: PMC4641328
Gautam V, Trinidad JC, Rimerman RA, Costa BM, Burlingame AL, Monaghan DT. Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D. Neuropharmacology. 2013 Nov;74:96-107. doi: 10.1016/j.neuropharm.2013.04.035. Epub 2013 Apr 29. PubMed PMID: 23639431; PubMed Central PMCID: PMC3855079
Costa BM, Yao H, Yang L, Buch S. Role of endoplasmic reticulum (ER) stress in cocaine-induced microglial cell death. J Neuroimmune Pharmacol. 2013 Jun;8(3):705-14. doi: 10.1007/s11481-013-9438-8. Epub 2013 Feb 13. PubMed PMID: 23404095; PubMed Central PMCID: PMC3663878
Collingridge GL, Volianskis A, Bannister N, France G, Hanna L, Mercier M, Tidball P, Fang G, Irvine MW, Costa BM, Monaghan DT, Bortolotto ZA, Molnár E, Lodge D, Jane DE. The NMDA receptor as a target for cognitive enhancement. Neuropharmacology. 2013 Jan;64:13-26. doi: 10.1016/j.neuropharm.2012.06.051. Epub 2012 Jul 11. Review. PubMed PMID: 22796429; PubMed Central PMCID: PMC4696548
Monaghan DT, Irvine MW, Costa BM, Fang G, Jane DE. Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators. Neurochem Int. 2012 Sep;61(4):581-92. doi: 10.1016/j.neuint.2012.01.004. Epub 2012 Jan 17. Review. PubMed PMID: 22269804; PubMed Central PMCID: PMC3360989
Irvine MW, Costa BM, Volianskis A, Fang G, Ceolin L, Collingridge GL, Monaghan DT, Jane DE. Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors. Neurochem Int. 2012 Sep;61(4):593-600. doi: 10.1016/j.neuint.2011.12.020. Epub 2012 Jan 13. PubMed PMID: 22265875; PubMed Central PMCID: PMC3394894
Buch S, Yao H, Guo M, Mori T, Mathias-Costa B, Singh V, Seth P, Wang J, Su TP. Cocaine and HIV-1 interplay in CNS: cellular and molecular mechanisms. Curr HIV Res. 2012 Jul;10(5):425-8. doi: 10.2174/157016212802138823. Review. PubMed PMID: 22591366; PubMed Central PMCID: PMC3824955
Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Laube B, Jane DE, Monaghan DT. Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid. Neuropharmacology. 2012 Mar;62(4):1730-6. doi: 10.1016/j.neuropharm.2011.11.019. Epub 2011 Dec 6. PubMed PMID: 22155206; PubMed Central. PMCID: PMC3269548
Irvine MW, Costa BM, Dlaboga D, Culley GR, Hulse R, Scholefield CL, Atlason P, Fang G, Eaves R, Morley R, Mayo-Martin MB, Amici M, Bortolotto ZA, Donaldson L, Collingridge GL, Molnár E, Monaghan DT, Jane DE. Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors. J Med Chem. 2012 Jan 12;55(1):327-41. doi: 10.1021/jm201230z. Epub 2011 Dec 14. PubMed PMID: 22111545; PubMed Central PMCID: PMC3269097
Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Skifter DA, Jane DE, Monaghan DT. A novel family of negative and positive allosteric modulators of NMDA receptors. J Pharmacol Exp Ther. 2010 Dec;335(3):614-21. doi: 10.1124/jpet.110.174144. Epub 2010 Sep 21. PubMed PMID: 20858708; PubMed Central PMCID: PMC2993558
NMDA receptor modulators and methods of use. United States patent application 61371221. 2010 August.
Costa BM, Feng B, Tsintsadze TS, Morley RM, Irvine MW, Tsintsadze V, Lozovaya NA, Jane DE, Monaghan DT. N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse. J Pharmacol Exp Ther. 2009 Nov;331(2):618-26. doi: 10.1124/jpet.109.156752. Epub 2009 Aug 14. PubMed PMID: 19684252; PubMed Central PMCID: PMC2775268
Delev D, Pavlova A, Heinz S, Blaise MC, Chandra T, Poetsch B, Seifried E, Oldenburg J. Modelling and expression studies of two novel mutations causing factor V deficiency. Thromb Haemost. 2008 Nov;100(5):766-72. PubMed PMID: 18989519.
Blaise MC, Sowdhamini R, Pradhan N. Comparative analysis of different competitive antagonists interaction with NR2A and NR2B subunits of N-methyl-D-aspartate (NMDA) ionotropic glutamate receptor. J Mol Model. 2005 Nov;11(6):489-502. doi: 10.1007/s00894-005-0258-5. Epub 2005 Jun 1. PubMed PMID: 15928921.
Blaise MC, Bhattacharyya D, Sowdhamini R, Pradhan N. Structural consequences of D481N/K483Q mutation at glycine binding site of NMDA ionotropic glutamate receptors: a molecular dynamics study. J Biomol Struct Dyn. 2005 Feb;22(4):399-410. doi: 10.1080/07391102.2005.10507012. PubMed PMID: 15588104.
Blaise MC, Sowdhamini R, Rao MR, Pradhan N. Evolutionary trace analysis of ionotropic glutamate receptor sequences and modeling the interactions of agonists with different NMDA receptor subunits. J Mol Model. 2004 Dec;10(5-6):305-16. doi: 10.1007/s00894-004-0196-7. Epub 2004 Oct 22. PubMed PMID: 15597199.
Pubmed Link: https://www.ncbi.nlm.nih.gov/myncbi/18Il7wm0VP5/bibliography/public/