Our research interests lie broadly in organic chemistry, polymer chemistry, materials chemistry, chemical biology, drug delivery, and nanomedicine, with emphasis on the translation of organic and polymer chemistry to functional nanomaterials designed for advanced disease treatment. Many therapeutic agents including small molecular drugs, nucleic acids, and proteins have limited efficacy and may cause serious side effects due to unsatisfactory physicochemical properties. We exploit cutting-edge organic and polymer syntheses to create functional nanomaterials to deliver these therapeutic agents to their targeted tissues, aiming to improve the current disease treatments. These efforts rely on fundamental synthetic methodology development to afford molecular and macromolecular substrates, each designed with unique compositions, structures, and properties to exhibit function. Students in the Zhang Research Group will receive multidisciplinary training in chemistry, materials science, engineering, and nanomedicine, and learn basic and advanced skills in organic and polymer synthesis, materials characterization, physical and biological performance testing, and develop innovative polymeric materials to address unmet needs in human health and sustainability. We aim to educate the next generation of scientists to meet unprecedented challenges in the ever-evolving society.
Congatulatiosn to Professor Fuwu Zhang for receiving Dean’s Excellence Award from University of Miami College of Arts and Sciences.
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We had a great time together to kick off the start of a new semester!
Dr. Zhang received prestigious NSF Faculty Early Career Development Program (CAREER) award. Congratulations!
We performed the "Polymer Magic Show" at Archimedean Academy! Students and teachers really enjoyed the show and fun experiments.
Prof. Zhang was interviewed by Executive Editor of BioIntegration Prof. Phei Er Saw. Click here for more details.
https://bio-integration.org/10-15212-bioi-2022-0021/
Shiwei received Outstanding TA Award for Excellence as a Chemistry Lab Instructor! Congratulations!
Transformative nanomedicine: We report a camptothecin (CPT) prodrug that was well formulated in solution and rapidly transformed into long-circulating nanocomplexes in vivo for highly efficient drug delivery and effective cancer therapy.
Zhang, F.; Zhu, G.;* Jacobson, O.; Liu, Y.; Chen, K.; Yu, G.; Ni, Q.; Fan, J.; Yang, Z.; Xu. F.; Fu, X.; Wang, Z.; Ma, Y.; Niu, G.; Zhao, X.; Chen, X.* ACS Nano, 2017, 11, 8838