News
2024, new paper in Nature Chemical biology: "Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning. Nat Chem Biol (2024)" link
2024, new book chapter contribution in Springer: "Cryo-electron Microscopy and Molecular Modeling Methods to Characterize the Dynamics of Tau Bound to Microtubules. Methods in Molecular Biology, 77–90 (2024)" link
2024, new article:"Discovery of the First‐in‐Class Inhibitors of Hypoxia Up‐Regulated Protein 1 (HYOU1) Suppressing Pathogenic Fibroblast Activation" Angew Chem Int Ed (2024) link
2024, new article:"Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability & Low Toxicity" in JCIM link
2023, Academy of Athens Award on "Pioneering Research Article in the Field of Chemistry, G. Fotinos". Here is a recent interview (in Greek) to APE-MPE
(2023)New research is out: "Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores" in JACS link
(2023)Our new article: "Optimizing molecular potential models by imposing kinetic constraints with path reweighting" with Peter Bolhuis and Bettna Keller, made it to JCP special edition "Machine Learning Hits Molecular Simulations" as well as to the cover! link
(2023)#Biochemistry publication#. Z. F. Brotzakis, T. Löhr, S. Truong, S. Hoff, M. Bonomi, & M. Vendruscolo. Determination of the Structure and Dynamics of the Fuzzy Coat of an Amyloid Fibril of IAPP Using Cryo-Electron Microscopy Biochemistry Article ASAP DOI: 10.1021/acs.biochem.3c00010 link
(2023)New JCTC publication: R. I. Horne, M. H. Murtada, Donghui Huo, Z. F. Brotzakis, R. C. Gregory, A. Possenti, S. Chia, and M. Vendruscolo. Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation JCTC Article ASAP 2023 link
(2023)New Nature comm. article: T. Bhardwaj, K. Gadhave, S.K. Kapuganti, P. Kumar, Z.F. Brotzakis et al. Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. Nat Commun 14, 945 (2023). link
(2023)New preprint Brotzakis Z. F., Zhang S & Vendruscolo M. (2023) AlphaFold Prediction of Structural Ensembles of Disordered Proteins doi: 10.1101/2023.01.19.524720
(2023)New article for facile use of MEMMI: Brotzakis Z. F*. (2023) Guide for determination of protein structural ensembles by combining Cryo-EM data with metadynamics. FEBS Open Bio https://doi.org/10.1002/2211-5463.1354
(2022) Interview of FEBS long-term fellows having participated in the FEBS Fellows Meeting 2022 (Vimeiro, Portugal) featuring in FEBS news
(2022)Invited speaker at the annual Hellenic Society of Biochemistry and Molecular Biology (Patras, GR)
(2022) Invited speaker at the "20 years of Metadynamics" CECAM meeting (Lausanne, CH)
Sept 2022: Awarded a 2 year post-doctoral fellowship from the Bodossakis foundation, between University of Cambridge (M. Vendruscolo) and BSRC Fleming (G. Skretas)