SCHOLARLY ARTICLE
Hollander, J. M., Goraltchouk, A., Rawal, M., Liu, J., Luppino, F., Zeng, L., & Seregin, A. (2023). Adeno-Associated Virus-Delivered Fibroblast Growth Factor 18 Gene Therapy Promotes Cartilage Anabolism. Cartilage, 14(4), 492–505. https://doi.org/10.1177/19476035231158774
Liu, Z., Hui Mingalone, C. K., Gnanatheepam, E., Hollander, J. M., Zhang, Y., Meng, J., Zeng, L., & Georgakoudi, I. (2023). Label-free, multi-parametric assessments of cell metabolism and matrix remodeling within human and early-stage murine osteoarthritic articular cartilage. Communications biology, 6(1), 405. https://doi.org/10.1038/s42003-023-04738-w
Liu, J., Liu, S., Zeng, L., & Tsilioni, I. (2023). Amyloid Beta Peptides Lead to Mast Cell Activation in a Novel 3D Hydrogel Model. International journal of molecular sciences, 24(15), 12002. https://doi.org/10.3390/ijms241512002
Hui Mingalone, C. K., Nehme, C. R., Chen, Y., Liu, J., Longo, B. N., Garvey, K. D., Covello, S. M., Nielsen, H. C., James, T., Messner, W. C., & Zeng, L. (2023). A novel whole "Joint-in-Motion" device reveals a permissive effect of high glucose levels and mechanical stress on joint destruction. Osteoarthritis and cartilage, 31(4), 493–506. https://doi.org/10.1016/j.joca.2022.10.018
Waitayangkoon, P., Moon, S. J., Tirupur Ponnusamy, J. J., Zeng, L., Driban, J., & McAlindon, T. (2023). Long-Term Safety Profiles of Macrolides and Tetracyclines: A Systematic Review and Meta-Analysis. Journal of clinical pharmacology, 10.1002/jcph.2358. Advance online publication. https://doi.org/10.1002/jcph.2358
Hollander, J. M., Li, L., Rawal, M., Wang, S. K., Shu, Y., Zhang, M., Nielsen, H. C., Rosen, C. J., & Zeng, L. (2022). A critical bioenergetic switch is regulated by IGF2 during murine cartilage development. Communications biology, 5(1), 1230. https://doi.org/10.1038/s42003-022-04156-4
Uchimura, T., Nakamura, D. S., Link, E. M., Noguchi, Y., Ōmura, S., Sunazuka, T., Greenblatt, D. J., & Zeng, L. (2019). Erythromycin acts through the ghrelin receptor to attenuate inflammatory responses in chondrocytes and maintain joint integrity. Biochemical pharmacology, 165, 79–90. https://doi.org/10.1016/j.bcp.2019.03.014
Hollander, J. M., & Zeng, L. (2019). The Emerging Role of Glucose Metabolism in Cartilage Development. Current osteoporosis reports, 17(2), 59–69. https://doi.org/10.1007/s11914-019-00506-0
Hui Mingalone, C. K., Liu, Z., Hollander, J. M., Garvey, K. D., Gibson, A. L., Banks, R. E., Zhang, M., McAlindon, T. E., Nielsen, H. C., Georgakoudi, I., & Zeng, L. (2018). Bioluminescence and second harmonic generation imaging reveal dynamic changes in the inflammatory and collagen landscape in early osteoarthritis. Laboratory investigation; a journal of technical methods and pathology, 98(5), 656–669. https://doi.org/10.1038/s41374-018-0040-9
Uchimura, T., Hollander, J. M., Nakamura, D. S., Liu, Z., Rosen, C. J., Georgakoudi, I., & Zeng, L. (2017). An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth. Development (Cambridge, England), 144(19), 3533–3546. https://doi.org/10.1242/dev.155598
Gibson, A. L., Hui Mingalone, C. K., Foote, A. T., Uchimura, T., Zhang, M., & Zeng, L. (2017). Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis. Scientific reports, 7, 41823. https://doi.org/10.1038/srep41823
Liu, Z., Pouli, D., Sood, D., Sundarakrishnan, A., Hui Mingalone, C. K., Arendt, L. M., Alonzo, C., Quinn, K. P., Kuperwasser, C., Zeng, L., Schnelldorfer, T., Kaplan, D. L., & Georgakoudi, I. (2017). Automated quantification of three-dimensional organization of fiber-like structures in biological tissues. Biomaterials, 116, 34–47. https://doi.org/10.1016/j.biomaterials.2016.11.041
Nakamura, D. S., Hollander, J. M., Uchimura, T., Nielsen, H. C., & Zeng, L. (2017). Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions. BMC musculoskeletal disorders, 18(1), 39. https://doi.org/10.1186/s12891-017-1410-y
Uchimura, T., Foote, A. T., Markel, D. C., Ren, W., & Zeng, L. (2016). The Chondroprotective Role of Erythromycin in a Murine Joint Destruction Model. Cartilage, 7(4), 373–387. https://doi.org/10.1177/1947603516630787
Uchimura, T., Foote, A. T., Smith, E. L., Matzkin, E. G., & Zeng, L. (2015). Insulin-Like Growth Factor II (IGF-II) Inhibits IL-1β-Induced Cartilage Matrix Loss and Promotes Cartilage Integrity in Experimental Osteoarthritis. Journal of cellular biochemistry, 116(12), 2858–2869. https://doi.org/10.1002/jcb.25232
Tang, X., Fan, L., Pei, M., Zeng, L., & Ge, Z. (2015). Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives. European cells & materials, 30, 12–27. https://doi.org/10.22203/ecm.v030a02
Leahy, A. A., Esfahani, S. A., Foote, A. T., Hui, C. K., Rainbow, R. S., Nakamura, D. S., Tracey, B. H., Mahmood, U., & Zeng, L. (2015). Analysis of the trajectory of osteoarthritis development in a mouse model by serial near-infrared fluorescence imaging of matrix metalloproteinase activities. Arthritis & rheumatology (Hoboken, N.J.), 67(2), 442–453. https://doi.org/10.1002/art.38957
Kwon, H., Rainbow, R. S., Sun, L., Hui, C. K., Cairns, D. M., Preda, R. C., Kaplan, D. L., & Zeng, L. (2015). Scaffold structure and fabrication method affect proinflammatory milieu in three-dimensional-cultured chondrocytes. Journal of biomedical materials research. Part A, 103(2), 534–544. https://doi.org/10.1002/jbm.a.35203
Rainbow, R. S., Won, H. K., & Zeng, L. (2014). The role of Nkx3.2 in chondrogenesis. Frontiers in biology, 9(5), 376–381. https://doi.org/10.1007/s11515-014-1321-3
Cairns, D. M., Pignolo, R. J., Uchimura, T., Brennan, T. A., Lindborg, C. M., Xu, M., Kaplan, F. S., Shore, E. M., & Zeng, L. (2013). Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia. The Journal of clinical investigation, 123(8), 3624–3633. https://doi.org/10.1172/JCI69746
Rainbow, R. S., Kwon, H., Foote, A. T., Preda, R. C., Kaplan, D. L., & Zeng, L. (2013). Muscle cell-derived factors inhibit inflammatory stimuli-induced damage in hMSC-derived chondrocytes. Osteoarthritis and cartilage, 21(7), 990–998. https://doi.org/10.1016/j.joca.2013.04.011
Kwon, H., Sun, L., Cairns, D. M., Rainbow, R. S., Preda, R. C., Kaplan, D. L., & Zeng, L. (2013). The influence of scaffold material on chondrocytes under inflammatory conditions. Acta biomaterialia, 9(5), 6563–6575. https://doi.org/10.1016/j.actbio.2013.01.004
Cairns, D. M., Liu, R., Sen, M., Canner, J. P., Schindeler, A., Little, D. G., & Zeng, L. (2012). Interplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells. PloS one, 7(7), e39642. https://doi.org/10.1371/journal.pone.0039642
Brand, J. A., McAlindon, T. E., & Zeng, L. (2012). A 3D system for culturing human articular chondrocytes in synovial fluid. Journal of visualized experiments : JoVE, (59), e3587. https://doi.org/10.3791/3587
Cairns, D. M., Lee, P. G., Uchimura, T., Seufert, C. R., Kwon, H., & Zeng, L. (2010). The role of muscle cells in regulating cartilage matrix production. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 28(4), 529–536. https://doi.org/10.1002/jor.21014
Cairns, D. M., Uchimura, T., Kwon, H., Lee, P. G., Seufert, C. R., Matzkin, E., & Zeng, L. (2010). Muscle cells enhance resistance to pro-inflammatory cytokine-induced cartilage destruction. Biochemical and biophysical research communications, 392(1), 22–28. https://doi.org/10.1016/j.bbrc.2009.12.138
Cairns, D. M., Sato, M. E., Lee, P. G., Lassar, A. B., & Zeng, L. (2008). A gradient of Shh establishes mutually repressing somitic cell fates induced by Nkx3.2 and Pax3. Developmental biology, 323(2), 152–165. https://doi.org/10.1016/j.ydbio.2008.08.024
Holowacz, T., Zeng, L., & Lassar, A. B. (2006). Asymmetric localization of numb in the chick somite and the influence of myogenic signals. Developmental dynamics : an official publication of the American Association of Anatomists, 235(3), 633–645. https://doi.org/10.1002/dvdy.20672
Zeng, L., Kempf, H., Murtaugh, L. C., Sato, M. E., & Lassar, A. B. (2002). Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes & development, 16(15), 1990–2005. https://doi.org/10.1101/gad.1008002
Murtaugh, L. C., Zeng, L., Chyung, J. H., & Lassar, A. B. (2001). The chick transcriptional repressor Nkx3.2 acts downstream of Shh to promote BMP-dependent axial chondrogenesis. Developmental cell, 1(3), 411–422. https://doi.org/10.1016/s1534-5807(01)00039-9
CONFERENCE PAPER
Dietary modification of insulin receptor abundance in the growth plate • 2020 • AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY 171:284
Tobolsky VA, Hollander J, Capellini T, Zeng L, Lieberman DE
Insulin and Energetic Regulation of Skeletal Growth • 2019 • AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY 168:247
Tobolsky VA, Hollander J, Capellini TD, Zeng L, Lieberman DE
Second harmonic generation imaging reveals alterations of collagen fibers that correlate with synovitis and cartilage damage in early experimental osteoarthritis • 2018 • OSTEOARTHRITIS AND CARTILAGE 26:S469-S470 https://doi.org/10.1016/j.joca.2018.02.886
Mingalone CH, Liu Z, Hollander J, Garvey K, Gibson A, Banks R, Zhang M, McAlindon T, Nielsen H, Georgakoudi I, Zeng L
A Whole Joint-in-Motion Culture System Reveals a Critical Role of Glucose in Regulating Articular Cartilage and Growth Plate Matrix Production • 2017 • TISSUE ENGINEERING PART A • 23:S103-S104
Mingalone CH, Nehme CR, Garvey K, Banks RE, James TP, Messner WC, Zeng L
Glucose Metabolism Mediates IGF-II's Regulation on Cartilage Development • 2017 • OSTEOARTHRITIS AND CARTILAGE 25:S286 https://doi.org/10.1016/j.joca.2017.02.482
Zeng L, Uchimura T, Nakamura D, Liu Z, Georgakoudi I, Rosen C
IGF-II inhibits promotes cartilage integrity in experimental osteoarthritis and IL-1β-induced catabolic activity in chondrocytes • 2015 • OSTEOARTHRITIS AND CARTILAGE 23:A297-A298 https://doi.org/10.1016/j.joca.2015.02.540
Zeng L, Uchimura T, Foote A, Matzkin E, Smith E
Assessment of Matrix Organization and Cell Metabolic Changes During the Early Stages of Osteoarthritis using High-Resolution Multiphoton Imaging • 2015 • TISSUE ENGINEERING PART A • 21:S337
Liu Z, Hui CK, Zeng L, Georgakoudi I
IGF-II INHIBITS PROMOTES CARTILAGE INTEGRITY IN EXPERIMENTAL OSTEOARTHRITIS AND IL-1β-INDUCED CATABOLIC ACTIVITY IN CHONDROCYTES • 2015 • OSTEOARTHRITIS AND CARTILAGE • 23:A297-A298 https://doi.org/10.1016/j.joca.2015.02.540
Zeng L, Uchimura T, Foote A, Matzkin E, Smith E
THE ROLE OF ERYTHROMYCIN/GHRELIN AXIS IN ARTICULAR CARTILAGE MAINTENANCE • 2015 • OSTEOARTHRITIS AND CARTILAGE • 23:A37 https://doi.org/10.1016/j.joca.2015.02.086
Zeng L, Uchimura T, Foote AT, Shi T, Ren W
Functional Roles of IGF-II on Cartilage during Postnatal Bone Growth under the Normal and Inflammatory Condition • 2014 • JOURNAL OF BONE AND MINERAL RESEARCH • 29:S494
Uchimura T, Zeng L
The role of Nkx3.2 in muscle/cartilage cell fate determination • 2007 • JOURNAL OF BONE AND MINERAL RESEARCH • 22:S388