RESEARCH ARTICLES
1. Salloum Y, Gros G, Quintero-Castillo K, Garcia-Baudino C, Rabahi S, Kurup AJ, Diabangouaya P, Pérez-Pascual D, Morales Castro RA, Boekhorst J, Villablanca EJ, Ghigo JM, Feijoo CG, Brugman S, Hernandez PP. IL-26 from ILCs regulates early-life gut epithelial homeostasis by shaping microbiota composition. The EMBO journal, 10.1038/s44318-025-00588-w. 22 Oct. 2025, doi:10.1038/s44318-025-00588-w
2. Kurup AJ, Mikdache A, Diabangouaya P, Gros G, Garcia-Baudino C, Undurraga CA, Sarrazin AF, Hernandez PP. Sox2 Regulates Lateral Line Morphogenesis via Yap/Taz-Mediated Mechanotransduction. bioRxiv, 18 Sep. 2025, doi:10.1101/2025.09.18.677037
3. Bonhomme D, Vaysset H, Ednacot EMQ, Rodrigues V, Salloum Y, Cury J, Wang A, Benchetrit A, Affaticati P, Hernandez Trejo V, Vittot P, Bories C, Cornec A, Levraud JP, Hernandez PP, Benaroch P, Morehouse BR, Bernheim A, Poirier EZ. A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway. Science 2025 Jul 24;389(6758):eadr8536. doi.org/10.1126/science.adr8536
4. Rabahi S, Marachlian E, Guendel F, Mikdache A, Quintero-Castillo K, Maurin L, Di Donato V, Janardhana Kurup A, Salloum Y, Diabangouaya P, Gros G, Garcia Baudino C, Medina-Yanez I, Levraud JP, Lutfalla G, Del Bene F, Boekhorst J, Feijoo C, Eberl G, Brugman S, Sumbre G, Hernandez PP. Interleukin-22 in enteroendocrine cells controls early-life gut motility through interactions with the microbiota. bioRxiv doi.org/10.1101/2025.04.25.650580
5. Elsaid R*, Mikdache A*, Diabangouaya P, Gros G, Hernandez PP. A non-invasive photoactivatable split-Cre recombinase system for genome engineering in zebrafish. iScience, 2024 Jul 07. (*) Equal contribution. doi.org/10.1016/j.isci.2024.110476
6. Elsaid R, Mikdache A, Quintero K , Salloum Y, Diabangouaya P, Gros G, Feijoo CG, Hernandez PP. Definitive hematopoiesis is dispensable to sustain erythrocytes and macrophages during zebrafish ontogeny. iScience, 2024 Jan 17;27(2):108922. doi.org/10.1016/j.isci.2024.108922
7. García-López JP, Grimaldi A, Chen Z, Meneses C, Bravo-Tello K, Brescian E, Banderas A, Burges SM*, Hernandez PP*†, & Feijoo CG*†. Ontogenetically distinct neutrophils differ in transcriptional profile and behavior in zebrafish. Nature Communications, (2023) 14:4942. (*) Corresponding author. (†) Equal contribution. doi.org/10.1038/s41467-023-40662-7
8. Morales RA, Rabahi S, Diaz OE, Salloum Y, Kern BC, Westling M, Luo X, Parigi SM, Monasterio G, Das S, Hernandez PP, Villablanca EJ. Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine. Mucosal Immunology 15, 940–951 (2022). doi.org/10.1038/s41385-022-00546-3
9. Schnepf D, Hernandez PP, Mahlakõiv T, Crotta S, Sullender ME, Peterson ST, Ohnemus A, Michiels C, Gentle I, Dumoutier L, Reis CA , Diefenbach A, Wack A, Baldridge MT, Staeheli P. Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22. PLoS ONE, 2021 Aug 16(8): e0247738. doi.org/10.1371/journal.pone.0247738
10. Kaya B, Doñas C, Wuggenig P, Diaz O, Morales R, Melhem H, Swiss IBD Cohort, Hernandez PP, Kaymak T, Das S, Hruz P, Ayata CK, Villablanca EJ, Niess JH. Lysophosphatidic acid-mediated GPR35 signaling in CX3CR1+ macrophages regulates the intestinal cytokine milieu. Cell Reports, 2020 Aug 4;32(5):107979. doi:10.1016/j.celrep.2020.107979
11. Coronado M, Solis CJ, Hernandez PP* and Feijoo CG*. Soybean meal-induced intestinal inflammation in zebrafish is T cell-dependent and has a Th17 cytokine profile. Frontiers in Immunology, 2019 April 02; 10:610. (*) Corresponding author. doi.org/10.3389/fimmu.2019.00610
12. Gronke K*, Hernandez PP*, Zimmermann J, Klose C, Kofoed-Branzk M, Guendel-Rojas F, Witkowski M, Tizian C, Amann L, Schumacher F, Glatt H, Triantafyllopoulou A, and Diefenbach A. Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature. 2019 Feb;566(7743):249-253. (*) Equal contribution. doi:10.1038/s41586-019-0899-7
13. Hernandez PP*, Strzelecka P, Athanasiadis E, Hall D, Robalo AF, Collins AM, Boudinot P, Levraud* JP, Cvejic* A. Single-cell transcriptional analysis reveals ILC-like cells in zebrafish. Science immunology. 16 Nov 2018: Vol. 3, Issue 29, eaau5265. (*) Corresponding author. doi:10.1126/sciimmunol.aau5265.
14. Hernandez PP, Mahlakoiv T, Nguyen N, Guendel F, Ryffel B, Hoelscher C, Dumoutier L, Renauld JC, Staeheli P and Diefenbach A. Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection. Nature Immunology, 2015 Jul;16(7):698-707. doi:10.1038/ni.3180.
15. Mahlakoiv T*, Hernandez PP*, Diefenbach A and Staeheli P. Leukocyte-derived IFN-a/b and epithelial IFN-l constitute a compartmentalized mucosal defense system that restricts enteric virus infections. PLoS Pathogens, 2015 Apr 7;11(4):e1004782. (*) Equal contribution. doi.org/10.1371/journal.ppat.1004782
16. Klose CS, Blatz K, d'Hargues Y, Hernandez PP, Kofoed-Nielsen M, Ripka JF, Ebert K, Arnold SJ, Diefenbach A, Palmer E, Tanriver Y. The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα(+) intraepithelial lymphocyte development. Immunity. 2014 Aug 21;41(2):230-43.
17. Hernandez PP, Undurraga CA, Gallardo V, Mackenzie N, Allende ML. Sublethal concentrations of waterborne copper induce cellular stress and cell death in zebrafish embryos and larvae. Biol Res. 2011;44(1):7-15.
18. Vonarbourg C, Mortha A, Bui VL, Hernandez PP, Kiss EA, Hoyler T, Flach M, Bengsch B, Thimme R, Hölscher C, Hönig M, Pannicke U, Schwarz K, Ware CF, Finke D, Diefenbach A. Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes. Immunity. 2010 Nov 24;33(5):736-51.
19. Olivari, FA, HERNANDEZ, PP, Allende, ML. Acute copper exposure induces oxidative stress and necrosis in lateral line hair cells of zebrafish. Brain Res. 2008 Dec;1244:1-12.
20. Hernandez PP, Olivari FA, Sarrazin AF, Sandoval PC, Allende ML. Regeneration in zebrafish lateral line neuromasts: expression of the neural progenitor cell marker sox2 and proliferation-dependent and –independent mechanisms of hair cell renewal. Dev Neurobiol. 2007 Apr;67(5):637-54. Cover image authorship.
21. Hernandez, PP, Moreno V, Olivari, F, Allende, ML. Sub-lethal concentrations of waterborne copper are toxic to lateral line neuromasts in zebrafish (Danio rerio). Hearing Res. 2006 Mar;213(1-2):1-10
REVIEWS
1. Hernandez PP, Gronke K, Diefenbach A. A catch-22: Interleukin-22 and cancerogenesis. Review. Eur J Immunol. 2018 Jan;48(1):15-31.
2. Hernandez PP, Allende ML. The zebrafish as a discovery model for copper metabolism genes and markers. Review. Am. J. Clin. Nutr. 2008 Sep;88(3):835S-9S.