Development and Homeostasis of Mucosal Tissues Group

Our goal is to decipher how the microbiota and the immune system modulate organ development and maturation as well as tissue homeostasis, regeneration, and physiology. We primarily focus on the gut as its resident immune system is constitutively and basally active in response to the vast microbiota that populates this organ during development. Our approach integrates knowledge and methodologies from developmental biology, immunology, and zebrafish genetics, alongside cutting-edge techniques such as single-cell transcriptomics and non-invasive live imaging.

More specifically, we study how interactions between immune and epithelial cells, mediated mainly by secreted signals such as cytokines, regulate intestinal maturation and homeostasis. Furthermore, we are currently determining how interactions between the gut microbiota and host epithelial, immune, and nerve cells promote the onset of physiological gut function.

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