Embedded Files
Shih, R.M. and Chen Y.Y.
CAR-T cells reshape the tumor microenvironment
Nature Reviews Bioengineering. 2026
Clubb, J.D., Shih, R.M., Shafer, A., Vajragiri, S., Lam, K., Talluri, S. Bouren, A., Brown, C.E., Ruivo, P., Prins, R.M., Wu, H.-C., Chen Y.Y.
Armored Chimeric Antigen Receptor-T Cell Therapy Targets Antigen-Heterogeneous Glioma
Cancer Research. 2026;86(15): 3781-3800
Gao, T.A., Shih, R.M., Clubb, J.D., Hung, S.-H., Singh, T., James-Allen, L.B., DiBernardo, G., Shafer, A., Bouren, A., Ayala Ceja, M., Ong, S., Ball, A.B., Divakaruni, A.S., Memarzadeh, S., Wu, H.-C., Chen Y.Y.
Science Translational Medicine. 2026;18(839): eadw9286
Kwon, N. and Chen Y.Y.
Overcoming solid-tumor barriers: armored CAR-T cell therapy
Trends in Cancer. 2025;11(10):1019-1029
Hou, A.J., Shih, R.M., Uy, B.R., Shafer, A., Chang, Z.L., Comin-Anduix, B., Guesses, M., Galic, Z., Phyu, S., Okada, H., Grausam, K.B., Breunig, J.J., Brown, C.E., Nathanson, D.A., Prins, R.M., Chen Y.Y.
Neuro-oncology. 2024;26(10):1850-1866.
Lakhani, A., Chen, X., Chen, L.C., Hong, M., Khericha, M., Chen, Y., Chen, Y.Y., Park, J.O.
Extracellular domains of CARs reprogramme T cell metabolism without antigen stimulation
Nature Metabolism. 2024:1143-1160.
Lin, M.-Y., Nam, E., Shih, R.M., Shafer, A., Bouren, A., Ayala Ceja, M., Harris, C., Khericha, M., Vo, K.H., Kim, M., Tseng, C.-H., and Chen, Y.Y.
Self-regulating CAR-T cells modulate cytokine release syndrome in adoptive T-cell therapy
Journal of Experimental Medicine. 2024;221(6):e20221988.
Jilani, S., Saco, J.D., Mugarza, E., ..., Chen, Y.Y., Ribas, A., and Puig-Saus, C.
Nature Communications. 2024:1244.
Ayala Ceja, M., Khericha, M., Harris, C.M., Puig-Saus, C., and Chen, Y.Y.
CAR-T Cell Manufacturing: Major Process Parameters and Next-Generation Strategies
Journal of Experimental Medicine. 2024;221(2):e20230903.
Hong, M., Talluri, S., and Chen, Y.Y.
Advances in promoting chimeric antigen receptor T cell trafficking and infiltration of solid tumors
Current Opinion in Biotechnology. 2023:103020.
Kohn D.B., Chen, Y.Y., and M.J. Spencer
Successes and challenges in clinical gene therapy
Gene Therapy. 2023:738-746.
Clubb, J.D., Gao, T.A., and Chen, Y.Y.
Synthetic Biology in the Engineering of CAR-T and CAR-NK Cell Therapies: Facts and Hopes
Clinical Cancer Research. 2023;29(8):1390–1402.
Larson, S.M., Walters, C.M., Ji, B., Ghafouri, S.N., Naparstek, J., Trent, J., Chen, J.M., Roshandell, M., Harris, C., Khericha, M., Schweppe, T., Berent-Maoz, B., Gosliner, S.B., Almaktari, A., Ayala Ceja, M., Allen-Auerbach, M.S., Said, J., Nasally, K., Mead, M., de Vos, S., Young, P.A., Oliai, C., Schiller, G.J., Timmerman, J.M., Ribas, A., and Chen, Y.Y.
Cancer Discovery. 2023;13(3):580-597.
Chen, X., Chen, L.C., Khericha, M., Meng, X., Salvetrini, E., Shafer, A., Iyer, N., Alag, A.S., Ding, Y., Nicolaou, D.M., and Chen, Y.Y.
Rational protein design yields CD20 CAR with superior antitumor efficacy compared to CD19 CAR
Cancer Immunology Research. 2023;11(2):150-163.
Cabera, A., Edelstein, H.I., Glykofrydis, F., ..., Chen, Y.Y.,...Deans, T.L.
The sound of silence: Transgene silencing in mammalian cell engineering
Cell Systems. 2022;13(12):950–973.
Gao, T.A. and Chen, Y.Y.
Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism
Annual Reviews of Chemical and Biomolecular Engineering. 2022:193–216.
Shih, R.M. and Chen, Y.Y.
Engineering Principles for Synthetic Biology Circuits in Cancer Immunotherapy
Cancer Immunology Research. 2022;10(1):6–11.
Hong, M. and Chen, Y.Y.
Cell. 2021;184(25):6017–6019.
Chen, L.C. and Chen, Y.Y.
News and Views: Bacteria recycle tumour waste to fuel immune cells
Nature. 2021;598(7882):570–571.
Hou, A.J. and Chen, Y.Y.
Programming Novel Cancer Therapeutics: Design Principles for Chimeric Antigen Receptors
Protein Engineering: Tools and Applications. 2021:353–375.
Chen, L.C., Hou, A.J., and Chen, Y.Y.
Viewpoint: Getting better mileage with logically primed CARs
Med. 2021;2(7):785-787.
Hou, A.J., Chen, L.C., and Chen, Y.Y.
Navigating CAR-T cells through the solid-tumour microenvironment
Nature Reviews Drug Discovery. 2021;20(7):531-550.
Hong, M., Clubb, J.D. and Chen, Y.Y.
Engineering CAR-T cells for next-generation cancer therapy
Cancer Cell. 2020;38(4):473–488.
Li, J.H. and Chen, Y.Y.
Preview: A Fresh Approach to Targeting Aging Cells: CAR-T Cells Enhance Senolytic Specificity
Cell Stem Cell. 2020;27(2):192–194.
Zah, E., Nam, E., Bhuvan, V., Tran, U., Ji, B.Y., Gosliner, S.B., Wang, X., Brown, C.E., and Chen, Y.Y.
Nature Communications. 2020;11(1):2283
Chang, Z.L., Hou, A.J., and Chen, Y.Y.
Engineering primary T cells with chimeric antigen receptors for rewired responses to soluble ligands
Nature Protocols. 2020:1507–1524.
Chen, L.C. and Chen, Y.Y.
Outsmarting and outmuscling cancer cells with synthetic and systems immunology
Current Opinion in Biotechnology. 2019:111-118.
Chen, Y.Y. and Van Deventer, J.A.
Editorial overview: Pharmaceutical biotechnology: new frontiers in protein, gene, and cell therapies
Current Opinion in Biotechnology. 2019:iii-v.
Hou, A.J.*, Chang, Z.L.*, Lorenzini, M.H., Zah, E., and Chen, Y.Y.
TGF-β–responsive CAR-T cells promote anti-tumor immune function
Bioengineering and Translational Medicine. 2018:85-86.
Ho, P. and Chen, Y.Y.
Synthetic Biology in Immunotherapy
Wiley Biotechnology Series--Synthetic Biology: Parts, Devices, and Applications. 2018:849-372.
Chang, Z.L., Lorenzini, M.H., Chen, X., Tran, U., Bangayan, N.J., and Chen, Y.Y.
Rewiring T-cell responses to soluble factors with chimeric antigen receptors
Nature Chemical Biology. 2018;14(3):317-324.
Wong, R.S., Chen, Y.Y., and Smolke, C.D.
Regulation of T cell proliferation with drug-responsive microRNA switches
Nucleic Acids Research. 2018:1541-1552.
Zah, E. and Chen, Y.Y.
Engineering Cancer-Fighting T Cells
Chemical Engineering Progress. 2017 Oct:40-46.
Ho, P. and Chen, Y.Y.
Mammalian synthetic biology in the age of genome editing and personalized medicine
Current Opinion in Chemical Biology. 2017:57-64.
Ho, P., Ede, C., and Chen, Y.Y.
ACS Synthetic Biology. 2017;6(8):1484-1495.
Chang, Z.L. and Chen, Y.Y.
CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond
Trends in Molecular Medicine. 2017;23(5):430-450.
Zah, E., Lin, M.Y., Silva-Benedict, A., Jensen, M.C., Chen, Y.Y.
Cancer Immunology Research. 2016;4(7):639-641.
Zah, E., Lin, M.Y., Silva-Benedict, A., Jensen, M.C., Chen, Y.Y.
Cancer Immunology Research. 2016;4(6):498-508.
Ede, C., Chen, X., Lin, M.Y., Chen, Y.Y.
ACS Synthetic Biology. 2016;5(5):395-404.
Chang, Z., Silver, P.A., Chen, Y.Y.
Journal of Translational Medicine. 2015;13(1):161.
Wei, K.Y., Chen, Y.Y., Smolke, C.D.
A yeast-based rapid prototype platform for gene-control elements in mammalian cells
Biotechnology and Bioengineering. 2013;110(4):1201-10.
Chen, Y.Y.*, Galloway, K.E.*, Smolke, C.D.
Synthetic biology: Advancing biological frontiers by building synthetic systems
Genome Biology. 2012;13(2):240. *These authors contributed equally.
Chen, Y.Y. & Smolke, C.D.
From DNA to targeted therapeutics: Bringing synthetic biology to the clinic
Science Translational Medicine. 2011;3(106):106ps42.
Beisel, C.L., Chen, Y.Y., Culler, S.J., Hoff, K.G., & Smolke, C.D.
Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing
Nucleic Acids Research. 2011;39(7):2981-94.
Chen, Y.Y., Jensen, M.C., & Smolke, C.D.
Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems
Proceedings of the National Academy of Sciences. 2010;107(19):8531-6.
Jewett, M.C., Miller, M.L., Chen, Y.Y., & Swartz, J.R.
Continued protein synthesis at low [ATP] and [GTP] enables cell adaptation during energy limitation
Journal of Bacteriology. 2009;191(3):1083-91.
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