The Han Lab investigates the cellular and molecular mechanisms that drive the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH). Using cultured cells and rodent models, we study how lifestyle factors, including diet and cannabinoid signaling, shape liver health and disease.
Our Mission
Liver disease is a growing global health burden, and MASLD is now one of its most common causes. Our lab aims to understand how simple fatty liver progresses to MASH, and ultimately to fibrosis and more advanced disease. By uncovering the molecular events behind this transition, we hope to identify new strategies for prevention and treatment.
Research Focus
Mechanisms of MASLD and MASH progression
The role of cannabinoids and cannabinoid and involved signaling in liver disease
Lifestyle influences on liver metabolism, inflammation and injury
Our Approach
We combine cell culture systems with rodent models of liver disease. Cell-based experiments let us dissect specific molecular pathways, and animal studies let us test how those pathways operate in a whole organism. Together they link cellular mechanisms to disease outcomes.
Our toolkit includes:
Histology to assess liver structure, fat accumulation, inflammation and fibrosis
Primary cell isolation to study individual liver cell types
RNA-based quantitative methods to measure gene expression
Protein-based quantitative methods to measure protein levels and signaling activity