The research of Dr. Zhou's Lab aims at resolving challenging technical problems associated with aging, bone disease, and bone injuries in health care. There are three main research focuses:

• Investigate mechanical properties of healthy and diseased bone at multiple scales ranging from tissue level to sub-millimeter and sub-micron scale using micro-mechanical testing methods.

• Measure and compare the biomechanics in human mandible and shoulder bone before and after orthopaedic implant surgery.

• Model and optimize mechanobiological factors during bone regeneration using a CT-based finite element model.

• Design patient-specific biomedical devices for bone disease and critical-sized bone defect treatments.