Research
Ongoing Projects
Ongoing Projects
Quantitative understanding of dynamic cell proliferation control during intestinal stem cell differentiation
Quantitative understanding of dynamic cell proliferation control during intestinal stem cell differentiation
I am investigating the coordinated regulation of cell proliferation and differentiation in the intestinal epithelium, using in-vivo mouse models as well as organoid models. In particular, I use multiplexed imaging, automated high-throughput analyses, and mathematical modeling of intestinal epithelial cell signaling to elucidate mechanisms of cell cycle control during differentiation.
I am investigating the coordinated regulation of cell proliferation and differentiation in the intestinal epithelium, using in-vivo mouse models as well as organoid models. In particular, I use multiplexed imaging, automated high-throughput analyses, and mathematical modeling of intestinal epithelial cell signaling to elucidate mechanisms of cell cycle control during differentiation.
Development of fluorescent live-cell reporters using machine learning algorithms for protein structure prediction
Development of fluorescent live-cell reporters using machine learning algorithms for protein structure prediction
I am developing live-cell fluorescent reporters to measure the dynamics of protein kinase activity, which regulates cell proliferation and differentiation in the intestinal epithelium. A rational pipeline combines molecular and structural biology approaches and uses machine learning algorithms for protein structure prediction to optimize reporter dynamics.
I am developing live-cell fluorescent reporters to measure the dynamics of protein kinase activity, which regulates cell proliferation and differentiation in the intestinal epithelium. A rational pipeline combines molecular and structural biology approaches and uses machine learning algorithms for protein structure prediction to optimize reporter dynamics.
