Software

• Clinical trial designs and simulations:

  • gsDesign2: an R package for group sequential design for non-proportional hazards and stratified designs.

  • simtrial: an R package for clinical trial simulation for time-to-event endpoints.

  • wpgsd: an R package for weighted parametric group sequential designs.

• Clinical trial analysis:

  • metalite: an R package to create metadata structure for ADaM data analysis and reporting.

  • metalite.ae: an R package for standard adverse events analysis.

  • metalite.sl: an R package for standard subject-level analysis.

  • forestly: an R package for interactive forest plots of adverse events (AE) for the Data Monitoring Committee (DMC).

  • boxly: an R package for interactive box plots in clinical trial analysis.

  • kmcurvely: an R package for interactive Kaplan-Meier plots in clinical trial analysis.