Research Articles (* first aurthor , † corresponding author)
35. J-S Ryu and J-E See et al. BRCA (Submitted)
34. J Lee,J Kweon, Y Kim† (2025) Emerging Trends in Prime Editing for Precision Genome Editing Experimental & Molecular Medicine 57:1381-1391(Invited Review) (Accepted)
33. J Kweon et al. Efficient DNA base editing via an optimized DYW-like deaminase (Submitted) (BioRxiv, DOI:10.1101/2024.05.15.594452)
32. SS Im*,J Seo*, JE You, HW Bang, Y-H Kim, J Kweon, Y Kim, D-M Shin, J Son† (2025) BIX01294 suppresses PDAC growth through inhibition of glutaminase-mediated glutathione dynamics Molecular Metabolism (10.1016/j.molmet.2025.102113)
31. HS Kim*, J Kweon, Y Kim† (2024) Recent advances in CRISPR-based functional genomics for the study of disease-associated genetic variants Experimental & Molecular Medicine (Invited Review) (DOI:10.1038/s12276-024-01212-3)
30. HR Kim*, J-K Hong, Y Kim, J-Y Choi† (2024) HEBP2 afects sensitivity to cisplatin and BCNU but not to paclitaxel in MDA‐MB‐231 breast cancer cells Toxicological Research 40:561-569
29. AR Han*, HR Shin*, J Kweon, SB Lee, SE Lee, E-Y Kim, E-J Chang, Y Kim†, SW Kim† (2024) Highly efficient genome editing via CRISPR-Cas9 ribonucleoprotein (RNP) delivery in mesenchymal stem cells BMB Reports 57(1):60-65
28. G Jang, J Kweon & Y Kim† (2023) CRISPR prime editing for unconstrained correction of oncogenic KRAS variants Communications Biology 6:681
(Featured in Communications Biology)
27. E-Y Kim*, J-E Kim*, Y-E Kim, B Choi, DH Sohn, S-O Park, Y-H Chung, Y Kim, WH Robinson, Y-G Kim†, E-J Chang† (2023) Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity Cell & Bioscience 13:48
26. G Jang*, HR Shin*, H-S Do*, J Kweon, S Hwang, S Kim, SH Heo, Y Kim† & BH Lee† (2023) Therapeutic gene correction for Lesch-Nyhan syndrome using CRISPR-mediated base and prime editing Molecular Therapy- Nucleic Acids 31:586-595
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25. J Kweon*, A-H Jang, E Kwon, U Kim, HR Shin, J-E See, G Jang, C Lee, T Koo, S Kim & Y Kim† (2023) Targeted dual base editing with Campylobacter jejuni Cas9 by a single AAV-mediated delivery Experimental & Molecular Medicine 55:377-384
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24. JS Kim*, JH Lee*, S-R Jeon, Y Kim, SH Jeon & HG Wu† (2023) Identification of Genes Involved in EGF-induced Apoptosis Using CRISPR/Cas9 Knockout Screening: Implications for Novel Therapeutic Targets in EGFR-Overexpressing Cancers Cancer Research and Treatment 55(3):737-745
23. J-E See & Y Kim† (2023) Functional analysis of variants in BRCA1 using CRISPR base-editors Methods in Molecular Biology 2606:73-85 (invited)
22. J Kweon*, H-Y Hwang*, H Ryu, A-H Jang, D Kim† & Y Kim† (2023) Targeted genomic translocations and inversions generated using a paired prime editing strategy Molecular Therapy 31(1):249-259
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21.Y-S Choi*, MJ Kim*, EA Choi, EJ Lee, MJ Park, M-J Kim, YW Kim, H-S Ahn, JY Jung, G Jang, Y Kim, H Kim, K Kim, JY Kim, S-M Hong, SC Kim† & S Chang† (2022) Antibody-mediated blockade for galectin-3 binding protein in tumor secretome abrogates PDAC metastasis PNAS 119 (30) e2119048119
20.E-Y Kim*, J-E Kim*, B Choi, J Kweon, S-O Park, H-S Lee, E-J Lee, S Oh, HR Shin, H Choi, Y Kim† & E-J Chang† (2021) AWP1 restrains the aggressive behavior of breast cancer cells induced by TNF-a Frontiers in Oncology 11:631469
19. J-E See*, HR Shin, G Jang, J Kweon† & Y Kim†(2021) Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors. JoVE 168:e61557
18. J Kweon*, J-K Yoon, A-H Jang, HR Shin, J-E See, G Jang, J-I Kim & Y Kim† (2021) Engineered Prime Editors with PAM flexibility. Molecular Therapy 29(6):2001-2007
17. HR Shin*, J-E See*, J Kweon, H-S Kim, G-J Sung, S Park, A-H Jang, G Jang, K-C Choi, I Kim, J-S Kim & Y Kim† (2021) Small-molecule Inhibitors of Histone Deacetylase Improve CRISPR-based Adenine Base Editing. Nucleic Acids Research 49(4):2390-2399
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16. HR Shin*, J Kweon & Y Kim† (2021) Gene manipulation using fusion guide RNAs for Cas9 and Cas12a. Methods in Molecular Biology 2162:185-193 (invited)
15. S Lee*, Y Shin, K Kim, Y Song, Y Kim & S-W Kang† (2020) Protein Translocation Acquires Substrate Selectivity Through ER Stress-Induced Reassembly of Translocon Auxiliary Components. Cells 9(2):518
14. H-K Kim*, EJ Lee, Y-J Lee, J Kim, Y Kim, K Kim, S-W Lee, S Chang, YJ Lee, JW Lee†, W Lee†, S Chun, BH Son, KH Jung, Y-M Kim, W-K Min & S-H Ahn (2020) Impact of proactive high-throughput functional assay data on BRCA1 variant interpretation in 3684 patients with breast or ovarian cancer. Journal of Human Genetics 65:209-220
13. J Kweon*, A-H Jang, HR Shin, J-E See, W Lee, JW Lee, S Chang, K Kim & Y Kim† (2020) A CRISPR-based base-editing screen for the functional assessment of BRCA1 variants. Oncogene 39(1): 30-35
12. H Eom*, Y Shin, Y Song, Y Kim & S-W Kang† (2020) ATP-driven reactions are required for the assembly of large stress granules. Biochemical and Biophysical Research Communications 521(1):238-244
11. HJ Lee*, B Choi*, Y Kim, SE Lee, HJ Jin, H-S Lee, E-J Chang† & SW Kim† (2019) The upregulation of Toll-like receptor 3 via autocrine IFN-beta signaling drives the senescence of human umibilical cord blood-derived mesenchymal stem cells through JAK1. Frontiers in Immunology 23 July 1659 (https://doi.org/10.3389/fimmu.2019.01659 )
10. B Koo*, D-E Kim*, J Kweon, CE Jin, S-H Kim, Y Kim† & Y Shin† (2018) CRISPR/dCas9-mediated biosensor for detection of tick-borne diseases. Sensors and Actuators B: Chemical 273:316-321
9. J Kweon* & Y Kim† (2018) High-throughput genetic screens using CRISPR–Cas9 system. Archives of Pharmacal Research 41(9):875-884 (Invited Review)
8. J Kweon*, D-E Kim*, A-H Jang & Y Kim† (2018) CRISPR/Cas-based customization of pooled CRISPR libraries. PLoS ONE 13(6):e0199473 / BioRxiv (doi:10.1101/187757)
7. D-S Park*, M Yoon*, J Kweon, A-H Jang, Y Kim† & S-C Choi† (2017) Targeted base editing via RNA-guided cytidine deaminases in Xenopus laevis embryos. Molecules and Cells 40(11):823-827
6. J Kweon*, A-H Jang, D-E Kim, JW Yang, M Yoon, HR Shin, J-S Kim & Y Kim† (2017) Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1. Nature Communications 8:1723
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5. HT Kang*, JT Park*†, K Choi*, Y Kim, H C Choi, CW Jung, Y-S Lee† & SC Park†(2017) Chemical screening identifies ATM as a target for alleviating senescence. Nature Chemical Biology 13(6):616-623
4. Y Kim*, S-A Cheong, JG Lee, S-W Lee†, MS Lee†, I-J Baek† & YH Sung† (2016) Generation of knockout mice by Cpf1-mediated gene targeting. Nature Biotechnology 34(8):808-810
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3. SW Cho*, S Kim*, Y Kim*, J Kweon, HS Kim, S Bae & J-S Kim† (2014) Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases. Genome Research 24:132-141
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2.Y Kim*, J Kweon* & J-S Kim† (2013) TALENs and ZFNs are associated with different mutation signatures. Nature Methods 10(3):185
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1. Y Kim*, J Kweon*, A Kim*, JK Chon*, JY Yoo*, HJ Kim, S Kim, C Lee, E Jeong, E Chung, D Kim, MS Lee, EM Go, HJ Song, H Kim, N Cho, D Bang, S Kim & J-S Kim† (2013) A library of TAL effector nucleases spanning the human genome. Nature Biotechnology 31(3):251-8
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Patents (Registration)
1. 뉴클레아제에 의해 유전자 변형된 세포를 농축시키는 방법 (대한민국, 1013804100000, 2014.03.26)
2. Methods for concentrating cells that are genetically altered by nucleases (일본, 2013-555364, 2016.11.15)
3. dCas9 단백질 및 표적 핵산 서열에 결합하는 gRNA를 이용한 핵산 검출의 민감도 및 특이도 향상용 조성물 및 방법 (대한민국 10-1964746)
4. T 세포 내 표적 위치로의 T 세포 수용체 삽입을 위한 재조합벡터 및 이를 이용한 T 세포 내 표적 위치로의 T 세포 수용체 삽입용 조성물 (대한민국 10-2152189 )