Drug efficacy evaluation

 Transitioning to large animal models, like the Jeju native black pig, for drug efficacy evaluation represents a significant advancement in biomedical research. This approach leverages the unique genetic background of the Jeju native black pig, known for its high-quality meat and distinct genetic traits, to develop a more relevant arthritis model. Genome-wide scans and characterizations of positive selection signatures have already provided insights into the genetic uniqueness of the Jeju black pig, which could be pivotal for identifying genes related to arthritis and other diseases.

Furthermore, the research into elucidating breed-specific variants among native pigs in Korea, including the Jeju native black pig, underlines the potential for discovering disease markers and for the development of biomaterials and drugs. This genetic investigation not only contributes to the preservation of a valuable genetic resource but also to the development of precise models for drug efficacy and toxicity testing, aligning with contemporary needs in medical research for more accurate and human-relevant data.

Autoimmune disease research

Recent research has established a link between the Western diet, characterized by high intake of fats, sugars, and processed foods, and the exacerbation of autoimmune diseases. This diet is implicated in promoting inflammation and obesity, both of which are risk factors for the development of autoimmune conditions such as rheumatoid arthritis (RA). Specifically, trans fatty acids found in the Western diet have been shown to exacerbate conditions like colitis, which shares common inflammatory pathways with RA. Additionally, animal-derived fats rich in saturated fatty acids, such as palmitic or stearic acid, have been demonstrated in mouse studies to contribute to inflammation, suggesting a mechanism by which diet influences autoimmune disease progression.

The laboratory's research on the Th1 type rheumatoid arthritis model aims to uncover how a high-fat and high-sugar diet contributes to the disease's mechanism. By identifying the dietary factors that exacerbate RA, the research could lead to targeted dietary recommendations and interventions that mitigate the impact of these environmental factors on autoimmune diseases. This approach not only aids in understanding RA's pathogenesis but also explores potential therapeutic targets for broader autoimmune disease management.