Learn the principle,
Utilize it for life quality.
Presentation
2023.10.28
We have presented recent results at Annual Conference on Mass Spectrometry Imaging and Integrated Topics (1st IMSIS Conference)
https://imsis2023.org/
Mass Spectrometry Imaging of Single Cells by Tapping-mode Scanning Probe Electrospray Ionization
Yoichi Otsuka, Kazuya Kabayama, Ayane Miura, Koichi Fukase, Michisato Toyoda
Presentation
2023.8.27
We have presented recent results at AOMSC-KSMS 2023.
Control and Utilize Periodic Motions for the Development of Time-of-flight Mass Spectrometer and Ambient Sampling-Ionization Technique (Invited Talk)
Yoichi Otsuka, Michisato ToyodaDevelopment of a real-time soil-gas measurement system using a multi-turn time-of-flight mass spectrometer (Poster)
Shunya Suzuki, Yo Toma, Toshinobu Hondo, Yosuke Kawai, Yoichi Otsuka, Michisato ToyodaEffect of Probe Oscillation Frequency on Mass Spectrometry Imaging of Mouse Brain Sections by t-SPESI (Poster)
Mengze Sun, Yoichi Otsuka, Maki Okada, Shuichi Shimma, Michisato Toyoda
Presentation
2023.5.30
We have presented recent results at 71st ASMS Conference on Mass Spectrometry and Allied Topics.
Mass spectrometry imaging of single cells by tapping-mode scanning probe electrospray ionization
Yoichi Otsuka, Kazuya Kabayama, Ayane Miura, Koichi Fukase, Michisato Toyoda
Paper
2023.2.2
The following paper was published.
Solvent effects of N,N-dimethylformamide and methanol on mass spectrometry imaging by tapping-mode scanning probe electrospray ionization
Otsuka, Nijiho One, Mengze Sun, Shuichi Shimma, Osamu Urakawa, Tomoya Kudo, Shinichi Yamaguchi and Michisato Toyoda,
Analyst, (2023). (Open Access)
https://doi.org/10.1039/D2AN01953A.
Paper
2023.1.16
The following paper was published.
Advances in Mass Spectrometry Imaging for Visualization of Cellular Information in Biological Tissues
Yoichi Otsuka, Proteome Letters, 7, 53-62 (2022). https://doi.org/10.14889/jpros.7.2_53
(Japanese)
Open Seminar
2023.1.10
"Frontiers of Ionization and Mass Spectrometry"
In cells, which are the basic units of living organisms, life activities are maintained by the complex interactions of a wide variety of molecules. The development of ionization methods in mass spectrometry has made it possible to visualize the distribution of components in biological tissues and to perform highly sensitive measurements, which is expected to expand the range of utilization of mass spectrometry from basic to applied fields.
In this workshop, three lecturers are invited to talk about the development of ionization methods and their application research. The seminar will provide an opportunity to learn about state-of-the-art research and discuss the future of ionization methods.
Date & Time: January 28, 2023, 13:30-17:00
Venue: Osaka University, Graduate School of Science (Room H701) and Zoom webinar (Hybrid meeting)
Registration: https://forms.gle/M8S2N7i2j3WapbWMA
Registration Fee: Free
Program:
13:30-13:35 Opening remarks
13:35～14:35 Lecture 1: Dr. Julia Laskin (Purdue University) “Ambient Imaging of Biological Tissues Using Nanospray Desorption Electrospray Ionization (nano-DESI) Mass Spectrometry”
14:35～15:35 Lecture 2: Dr. Toshinobu Hondo (Osaka University) “Supercritical fluid chromatography-proton transfer reaction (water ion chemical) ionization mass spectrometry — Endeavor to a single-cell metabolite determination”
15:35～15:50 Break
15:50～16:50 Lecture 3: Dr. Cheng Li-Chuin (University of Yamanashi) “In pursuit of novel applications using super-atmospheric pressure ionization mass spectrometry”
16:50-17:00 Closing remarks
Organizer: Yoichi Otsuka (Osaka University), Rika Miyake (Osaka University), Takae Takeuchi (Nara Women's University)
Contact: Yoichi Otsuka (Osaka University) E-mail: Otsuka “at-sign” phys.sci.osaka-u.ac.jp
Presentation
2023.1.10
We will present our recent results at International Mass Spectrometry Imaging Symposium (IMSMI) 2023 Kyoto
https://www.kbmss.org/sympo6-poster/
Effect of Probe Vibration Frequency on Tapping-Mode Scanning Probe Electrospray Ionization
Mengze Sun, Yoichi Otsuka, Maki Okada, Shuichi Shimma, Michisato ToyodaMass Spectrometry Imaging of mouse testis by tapping mode scanning probe electrospray ionization
Maki Okada, Yoichi Otsuka, Sun Mengze, Hideo Shindou, Tomomi Yoshida, Michisato ToyodaDevelopment of tapping-mode scanning probe electrospray ionization for lipid imaging of tissues
Yoichi Otsuka, Shuichi Shimma, Hidataka Kioka, Tomohito Ohtani, Yasushi Sakata
Paper
2022.5.4
The following paper was published.
Shape-Dependent Conduction Regime in Self-Doped Polyaniline
Jiannan Bao, Yoichi Otsuka, Hiroshi Ohoyama, and Takuya Matsumoto
J. Phys. Chem. C (2022)
Paper
2022.1.5
The following paper was published.
In-Materio Reservoir Computing in a Sulfonated Polyaniline Network
Yuki Usami, Bram van de Ven, Dilu G. Mathew, Tao Chen, Takumi Kotooka, Yuya Kawashima, Yuichiro Tanaka, Yoichi Otsuka, Hiroshi Ohoyama, Hakaru Tamukoh, Hirofumi Tanaka, Wilfred G. van der Wiel, Takuya Matsumoto
Advanced Materials, 33, 2102688 (2021).
Award
2021.12.8
We received the presentation award
Name of Conference: The Chemical Society of Japan Fall Meeting, The 11th CSJ Chemistry Festa 2021
Name of Award: Excellent Poster Presentation Award
Recipient: Yuto Itoi (Department of Chemistry, Graduate School of Science, Osaka University)
Title of Presentation: Rapid Derivatization Reaction of Peptides Using Micro-Charged Droplets
Date of Award：2021/12/1
Award
2021.08.29
We received the presentation award
Name of Conference: The 15th Kinki Branch Summer Seminar for Young Researchers in 2021
Name of Award: "Science Art Award"
Recipient: Niho Ohte (Department of Biological Sciences, Faculty of Science, Osaka University)
Presentation title: Solvent selectivity of lipid measurement using scanning probe electrospray ionization mass spectrometry
Paper
2021.07.01
The following paper was published.
Direct Liquid Extraction and Ionization Techniques for Understanding Multimolecular Environments in Biological Systems
Yoichi Otsuka
Mass Spectrometry 10, A0095 (2021).
https://doi.org/10.5702/massspectrometry.A0095T
Paper
2021.04.16
The following paper was published.
Tapping-mode scanning probe electrospray ionization: fusion of SPM with mass spectrometry
Yoichi Otsuka
Jpn. J. Appl. Phys. 60 SE0802 (2021).
https://doi.org/10.35848/1347-4065/abefac
Promotion
2021.04.25
I have been appointed as an associate professor in the mass spectrometry group (Prof. Michisato Toyoda's laboratory), department of physics, graduate school of science, Osaka University.
Paper
2021.02.25
The following article is published.
Sacrificial gold coating enhances transport of liquid metal in pressurized fountain pen lithography
Gideon I. Livshits, Jiannan Bao, Leo Sakamoto, Tomoki Misaka, Yuki Usami, Yoichi Otsuka, Takuya Matsumoto
Sci. Rep. (2021) 11:4670.
https://www.nature.com/articles/s41598-021-84065-4.pdf
Paper
2021.01.06
The following article is published.
High spatial resolution multi-modal imaging by tapping-mode scanning probe electrospray ionization with feedback control
Yoichi Otsuka*, Bui Kamihoriuchi, Aya Takeuchi, Futoshi Iwata, Sara Tortorella, Takuya Matsumoto,
Analytical Chemistry,
https://doi.org/10.1021/acs.analchem.0c04144.
Paper
2020.12.18
The following article is published.
Homogeneous chemical state of self-doped polyaniline sub-micrometer thickness lines fabricated by fountain-pen lithography
Jiannan Bao, Yoichi Otsuka*, Takuya Matsumoto*
Jpn. J. Appl. Phys. 60, 015002 (2020)
https://iopscience.iop.org/article/10.35848/1347-4065/abd04e
Award (MSSJ RESEARCH AWARD)
2020.07.06
We received the MSSJ Research Award for our research.
Award recipient: Yoichi Otsuka
Award contents: Research and development of scanning probe electrospray ionization
http://www.mssj.jp/about/awards.html
We would like to thank everyone involved.
Paper
2020.06.27
The following article is published.
Local-field-induced current noise in shape-limited self-doped polyaniline
Jiannan Bao, Yoichi Otsuka, Riko Etoh, Yuki Usami and Takuya Matsumoto
Nanotechnology 31, 365203 (2020).
https://iopscience.iop.org/article/10.1088/1361-6528/ab96e4
Presentation (ASEAN-OU Chemistry Symposium 2020)
2020.01.17
We have presented our recent results at the ASEAN-OU Chemistry Symposium 2020
Development of scanning probe electrospray ionization for the visualization of chemical components in biological tissue
Yoichi Otsuka
Presentation (AOMSC2020)
2020.01.09
We have presented our recent results at the 8th Asia-Oceania Mass Spectrometry Conference 2020.
Mass spectrometry imaging of human heart tissue by scanning probe electrospray ionization mass spectrometry with feedback control system
Yoichi Otsuka, Bui Kamihoriuchi, Aya Takeuchi, Shuichi Shimma, Hiroshi Miyawaki, Hidetaka Kioka, Tomohito Otani, Yasushi Sakata, Takuya Matsumoto