Research

NMRは化学者が最も得意とする分析法の一つであり、生理条件下での立体構造解析が唯一可能な手法です。我々は、このNMRを軸として、大腸菌・細胞・植物を用いた試料調製や機能解析、超高磁場NMR装置などを用いた機器分析、等温滴定型熱量計やNMRを用いた解離会合の平衡論的速度論的解析、スーパーコンピューターを用いた計算機実験など、最先端の構造・機能解析を行い、生体高分子や生命活動の謎を解明し、化合物による生命現象の制御に挑戦します。

NMR spectroscopy is a powerful tool for molecular characterization and provides unique opportunities to determine three-dimensional structures and investigate molecular dynamics under physiologically relevant solution conditions. By placing NMR at the center of our research, we combine high-field NMR spectroscopy with recombinant protein production in Escherichia coli, cell-based functional assays using cultured human cells, thermodynamic and kinetic analyses of molecular interactions by isothermal titration calorimetry and NMR, and computational modeling and simulations. Through this integrated approach, we aim to elucidate the structures, dynamics, interactions, and functions of biological macromolecules, uncover the molecular mechanisms underlying biological processes, and develop chemical strategies to modulate them.