Research

Key Research Areas 

1. Discovery of Bioactive Natural Products

Our research focuses on the systematic identification of novel secondary metabolites from diverse natural sources, including terrestrial plants and insects. We employ advanced isolation techniques to find lead compounds for the treatment of complex diseases such as cancer, inflammatory disorders, etc.

• Bioassay-guided isolation of therapeutic scaffolds.

• Structural elucidation of complex molecules using 1D/2D NMR and Mass Spectrometry.

• Investigation of structure-activity relationships (SAR) for natural and synthetic derivatives.

2. Advanced Analytical Methodology & Quality Control

We develop rigorous analytical frameworks to ensure the standardization and quality of herbal medicines. By leveraging Quantitative NMR (qNMR), we establish precise protocols for the absolute quantitation of active ingredients without the need for identical reference standards.

• Development of qNMR methods for natural products.

• Creation of digital reference standards for automated pharmaceutical analysis.

• Standardization of multi-component herbal formulas.

3. Metabolomics & Chemical Profiling

Utilizing multi-platform metabolic profiling, we investigate the chemical consistency of medicinal herbs. This approach enables a comprehensive understanding of the chemical makeup of natural products.

• Metabolomic integration of countercurrent separation and NMR/MS data.

• Monitoring chemical changes during the processing of traditional medicines.

• Statistical analysis for quality evaluation and origin identification.

4. Computational Chemistry & Quantum Mechanical Analysis

To resolve challenging structural problems, we integrate experimental data with computational tools. We use quantum-mechanical (QM)-based computational tools to calculate NMR spectra and to confirm compound structures.

• QM-based NMR spectra calculation for structural validation.

• Computational analysis of stereochemistry and conformational preferences.