Publications
29. Lee, C.†; Lee, S.†; Kim, A.; Kwon, Y.* "Nitro-Enabled Atroposelective Dynamic Kinetic Resolution of 2-Arylindoles by Phase-Transfer Catalysis" Org. Lett. 2024, 26, 681−686 (†equally contributed first authors). <link>
28. Cho, H.-A†; Kim, S.†; Hwang, M.; Dongbang, S.; Kwon, Y.* "Catalytic Decarboxylative Asymmetric Allylic Alkylation for the Synthesis of Axially Chiral Biaryls" Asian J. Org. Chem. 2024, Accepted Article (†equally contributed first authors). <link>
[Special Collection on "Early Career Researcher" ]
27. Kim, S.; Kim, S.; Kim, S.; Kim, N.; Lee, S. W.; Yi, H.; Lee, S.; Sim, T.*; Kwon, Y.*; Lee, H. S.* "Affinity-Directed Site-Specific Protein Labeling and Its Application to Antibody-Drug Conjugates" Adv. Sci. 2024, 11, 2306401. <link>
[Hot Topic:"Bioorthogonal Chemistry" ]
26. Kim, A.; Lee, C.; Song, J.; Lee, S. K.; Kwon, Y.* "All-round catalytic and atroposelective strategy via dynamic kinetic resolution for N-/2-/3-arylindoles" Nat. Commun. 2023, 14, 5502. <link>
25. Song, J.*; Kim, A.; Hong, I.; Kim, S.; Byun, W. S.; Lee, H. S.; Kim, H. S.; Lee, S. K.*; Kwon, Y.* "Synthesis and biological evaluation of atropisomeric tetrahydroisoquinolines overcoming docetaxel resistance in triple-negative human breast cancer cells" Bioorg. Chem. 2023, 137, 106573. <link>
24. Kim, S.; Kim, A.; Lee, C.; Moon, J,; Hong, E. J.; Lee, D.-H.; Kwon, Y.* "Atroposelective Desymmetrization of 2-Arylresorcinols via Tsuji-Trost Allylation" Commun. Chem. 2023, 6, 42. <link>
23. Kang, D.; Lee, J. I.; Maeng, B.; Lee, S.; Kwon, Y.; Kang, M. S.; Park, J.*; Kim, J.* "Safe, Durable, and Sustainable Self-Powered Smart Contact Lenses" ACS Nano 2022, 16(10), 15827−15836. <link>
22. Kim, A.; Moon, J.; Lee, C.; Song, J.; Kim, J.; Kwon, Y.* “Organocatalytic Atroposelective Synthesis of Isoquinolines via Dynamic Kinetic Resolution" Org. Lett. 2022, 24(4), 1077−1082. <link>
21. Kim, A.; Kwon, Y.* “Catalytic Atroposelective Dynamic Kinetic Resolution of Substituted Indoles" Synlett 2022, 33(3), 201−206. <link>
[Invited Synpacts article]
20. Kim, A.†; Kim, A.†; Park, S.; Kim, S.; Jo, H.; Ok, K. M.; Lee, S. K.; Song, J.; Kwon, Y.* “Catalytic and Enantioselective Control of the C−N Stereogenic Axis via the Pictet−Spengler Reaction" Angew. Chem. Int. Ed. 2021, 60(22), 12279−12283. (†equally contributed first authors) <link>
19. Featherston, A. L.†; Kwon, Y.†; Pompeo, M. M.†; Engl, O. D.; Leahy, D. K.*; Miller, S. J.* “Catalytic Asymmetric and Stereodivergent Oligonucleotide Synthesis” Science, 2021, 371(6530), 702−707 <link>; ChemRxiv (preprint), posted on 28.10.2020. (†equally contributed first authors) <link>
18. Yang, J.; Lee, S. J.; Kwon, Y.; Ma, L.; Kim, J.* “Tumor suppressive function of Matrin 3 in the basal-like breast cancer” Biol. Res. 2020, 53, 42. <link>
17. Kim, S. B.; Lee, T.; Moon, H. S.; Ki, S. H.; Oh, Y. S.; Lee, J.-Y.; Kim, S.-B.; Park, J.-E.; Kwon, Y.; Kim, S.; Baek, D. J.*; Park, E.-Y.* “Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity” Molecules, 2020, 25(11), 2484. <link>
16. Shrestha, J.; Hwang, G. T.; Lee, T.; Kim, S. W.; Oh Y. S.; Kwon, Y.; Hong, S. W.; Kim, S.; Moon, H. S.; Baek, D. J.*; Park, E.-Y.* “Synthesis and Biological Evaluation of BODIPY-PF-543” Molecules, 2019, 24(23), 4408. <link>
Publications as a postdoctoral associate with Professor Scott J. Miller at Yale
15. Kwon, Y.; Li, J.; Reid, J. P.; Crawford, J. M.; Jacob, R.; Sigman, M. S.*; Toste, F. D.*; Miller, S. J.* “Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration” J. Am. Chem. Soc. 2019, 141, 6698−6705. <link>
14. Kwon, Y.; Chinn, A. J.; Kim, B.; Miller, S. J.* “Divergent Control of Point and Axial Stereogenicity: Catalytic Enantioselective C−N Bond-Forming Cross-Coupling and Catalyst-Controlled Atroposelective Cyclodehydration” Angew. Chem. Int. Ed. 2018, 57(21), 6251−6255. <link>
[‘VIP’ (Very Important paper) in Angewandte Chemie]
[Highlighted in Chemistry Views]
13. Chinn, A. J.; Kim, B.; Kwon, Y.; Miller, S. J.* “Enantioselective Intermolecular C–O Bond Formation in the Desymmetrization of Diarylmethines Employing a Guanidinylated Peptide-Based Catalyst” J. Am. Chem. Soc. 2017, 139(49), 18107−18114. <link>
Publications as a student with Professor Sanghee Kim at SNU
12. Yu, S.; Oh, J.; Li, F.; Kwon, Y.; Cho, H.; Shin, J.; Lee, S. K.*; Kim, S.* “New Scaffold for Angiogenesis Inhibitors Discovered by Targeted Chemical Transformations of Wondonin Natural Products” ACS Med. Chem. Lett. 2017, 8(10), 1066−1071. <link>
11. Park, H.; Kwon, Y.; Shin, J. E.; Kim, W.-J.; Hwang, S.; Lee, S.; Kim, S.* “Orthoester in Cyclodehydration of Carbamate-Protected Amino Alcohols under Acidic Conditions” Synthesis 2017, 49(12), 2761−2767. <link>
10. Kwon, Y.†; Jung, J.†; Kim, J. H.; Kim, W.-J.; Kim, S.* “Amide Acetal in Palladium-Catalyzed Allylation with Allylic Alcohols under Neutral Conditions” Asian J. Org. Chem. 2017, 6(5), 520−526. (†equally contributed first authors) <link>
9. Kwon, Y.†; Song, J.†; Lee, H.; Kim, E.-Y.; Lee, K.; Lee, S. K.*; Kim, S.* “Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents” J. Med. Chem. 2015, 58(19), 7749−7762. (†equally contributed first authors) <link>
8. Song, J.; Kwon, Y.; Kim, S.; Lee, S. K.* “Antitumor Activity of Phenanthroindolizidine Alkaloids Is Associated with Negative Regulation of Met Endosomal Signaling in Renal Cancer Cells” Chem. Biol. 2015, 22(4), 504−515. <link>
7. Kwon, Y.; Song, J.; Bae, H.; Kim, W.-J.; Lee, J.-Y.; Han, G.-H.; Lee, S. K.; Kim, S.* “Synthesis and Biological Evaluation of Carbocyclic Analogues of Pachastrissamine” Mar. Drugs 2015, 13(2), 824−837. <link>
6. In, J.; Lee, S.; Kwon, Y.; Kim, S.* “Divergent Total Synthesis of the Tricyclic Marine Alkaloids Lepadiformine, Fasicularin, and Isomers of Polycitorols by Reagent-Controlled Diastereoselective Reductive Amination” Chem. Eur. J. 2014, 20(52), 17433−17442. <link>
5. Hwang, S.; Park, H.; Kwon, Y.; Kim, S.* “Acid promoted cyclodehydration of amino alcohols with amide acetal” RSC Adv. 2014, 4(104), 60017−60024. <link>
4. Kwon, Y.; Kim, I.; Kim, S.* “Platinum-Catalyzed Synthesis of Substituted Phenanthrenes from Biphenyl Propargyl Alcohols via a Carbene Intermediate” Org. Lett. 2014, 16(18), 4936−4939. <link>
3. Kwon, Y.; Cho, H.; Kim, S.* “Expedient Synthesis of Phenanthrenes via In(III)-Catalyzed 6-Exo-Dig Cycloisomerization” Org. Lett. 2013, 15(4), 920−923. <link>
2. Kwon, Y.†; Song, J.†; Lee, B.; In, J.; Song, H.; Chung, H.-J.; Lee, S. K.*; Kim, S.* “Design, synthesis, and evaluation of a water-soluble antofine analogue with high antiproliferative and antitumor activity” Bioorg. Med. Chem. 2013, 21(4), 1006−1017. (†equally contributed first authors) <link>
1. Kwon, Y.; Lee, S.; Oh, D.-C.*; Kim, S.* “Simple Determination of Double Bond Positions in Long-Chain Olefins by Cross-Metathesis” Angew. Chem. Int. Ed. 2011, 50(36), 8275−8278. <link>
Patents
4. Kwon, Y.; Kim, S.; Moon, J. “Method for preparing atropisomers and desymmetric compound used in the method for preparing the same” Korea Application No. 10-2023-0103284 filed on 08/08/23.
3. Kwon, Y.; Kim, A.; Moon, J.; Lee. C. “Producing method of isoquinoline compound derivatives” Korea Application No. 10-2022-0114117 filed on 09/08/22.
2. Kim, S.; Lee, S. K.; Song, J.; Kwon, Y.; Kim, M.; Shin, J.; Jang, Y. “Composition for treating Coronavirus Disease-19 comprising phenanthroindolizidine and phenanthroquinolizidine alkaloid derivatives, optical isomer thereof, or pharmaceutically acceptable salts there of” Korea Application No. 10-2020-0108099 filed on 08/26/20, Korea Patent No. 10-2249543-0000 issued on 04/30/21.
1. Kim, S.; Lee, S. K.; Kwon, Y.; Song, J. “Phenanthroindolizidine or phenanthroquinolizidine alkaloid derivatives, optical isomer thereof, or pharmaceutically acceptable salts thereof, and an anticancer composition containing the same as an active ingredient” Korea Application No. 10-2016-0008924 filed on 01/25/16, Korea Patent No. 10-1806487-0000 issued on 12/01/17.