Publications
Peer-reviewed Publications
39. Yan Xiong, Stanislav Tsitkov, Henry Hess, Oleg Gang*, Yifei Zhang*. Microscale colocalization of cascade enzymes yields activity enhancement. ACS Nano, 2022, https://doi.org/10.1021/acsnano.2c00475.
38. Chang Ge, Zheng Yu, Huakang Sheng, Xiaolin Shen, Xinxiao Sun, Yifei Zhang, Yajun Yan, Jia Wang*, Qipeng Yuan* Redesigning regulatory components of quorum-sensing system for diverse metabolic control. Nature Communications. 2022, 13, 2182.
36. Yifei Zhang*, Yunzhenshan Gao, You Yong, Lectin-mediated coimmobilization of cascade glycoenzymes, Methods in Molecular Biology, 2022, 2487, 189–195.
35. Yifei Zhang*，Henry Hess*. Chemically-powered swimming and diffusion in the microscopic world. Nature Reviews Chemistry, 2021.
34. Yifei Zhang*, Henry Hess*. Actuating macroscopic machines with nanoscopic engines, Matter, 2021, 4, 1-2.
33. Yifei Zhang*, Henry Hess. Microenvironmental engineering: an effective strategy for tailoring enzymatic activities. Chinese Journal of Chemical Engineering, 2020, DOI: 10.1016/j.cjche.2020.04.010
32. Yifei Zhang*, Henry Hess. Inhibitors in Commercially Available 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonate) Affect Enzymatic Assays, Analytical Chemistry, 2020, 92, 1, 1502-1510.
31. Weina Xu, Zhongwang Fu, Gong Chen, Zheyu Wang, Yupei Jian, Yifei Zhang, Guoqiang Jiang, Diannan Lu, Jianzhong Wu, Zheng Liu*. Graphene oxide enabled long-term enzymatic transesterification in an anhydrate gas flux. Nature Communications, 2019, 10, 2684.
30. Yifei Zhang, Henry Hess. Enhanced diffusion of catalytically active enzymes. ACS Central Science, 2019, 5, 6, 939-948
29. Yifei Zhang, Megan Armstrong, Neda Bassir Kazeruni and Henry Hess. Aldolase does not show enhanced diffusion in dynamic light scattering experiments Nano Letters, 2018, 18 (12), 8025–8029.
28. Yifei Zhang, Stanislav Tsitkov, Henry Hess. Complex dynamics in a two-enzyme reaction network with substrate competition, Nature Catalysis, 2018, 1, 276–281. (Featured on the cover. Also see the Behind the paper story in the Nature Research Chemistry Community here.) [link]
Enzyme network by design
The construction of enzymatic reaction networks in vitro with predictable dynamics of interest is an emerging area of synthetic and systems biology. Zhang et al. present a two-enzyme reaction network with delayed substrate competition that can generate tunable pulse responses, be used for a ‘green bottle’ experiment and drive and visualize Rayleigh–Bénard Convection.
27. Amy Tsui-Chi Lam, Stanislav Tsitkov, Yifei Zhang, Henry Hess. Reversibly bound kinesin-1 motor proteins propelling microtubules demonstrate dynamic recruitment of active building blocks. Nano Letters, 2018, 18, 1530–1534. [link]
26. You Yong, Rui Su, Xuerun Liu, Weina Xu, Yifei Zhang, Rui Wang, Pingkai Ouyang, Jianzhong Wu, Ge Jun, Zheng Liu. Lectin corona enhances enzymatic catalysis on the surface of magnetic nanoparticles. Biochemical Engineering Journal, 2018, 129, 26–32. [link]
25. Yifei Zhang, and Henry Hess. Toward rational design of high-efficiency enzyme cascade. ACS Catalysis, 2017, 7, 6018–6027. (Invited Viewpoint) [link]
24. Yifei Zhang, Qin Wang, Henry Hess. Increasing enzyme cascade throughput by pH-engineering the microenvironment of individual enzymes. ACS Catalysis, 2017, 7, 2047–2051. [link]
23. Yifei Zhang, Stanislav Tsitkov, Henry Hess. Proximity does not contribute to activity enhancement in the glucose oxidase-horseradish peroxidase cascade. Nature Communications, 2016, 7, 13982. [link]
22. Yifei Zhang, You Yong, Jun Ge, Zheng Liu. Lectin agglutinated multienzyme catalyst with enhanced substrate affinity and activity. ACS Catalysis, 2016, 6, 3789−3795. [link]
21. Yuki Oda, Yifei Zhang, Jun Ge, Zheng Liu. Epoxidation of fatty acids by pluronic-conjugated lipase in organic media. Catalysis Letters, 2016, 146, 1073−1078. [link]
20. Hou Miao, Rui Wang, Yifei Zhang, Jun Ge, Zheng Liu. Synthesis of lutein esters by using a reusable lipase-pluronic conjugate as the catalyst. Catalysis Letters, 2016, 145, 1825−1829. [link]
19. Yifei Zhang, Jun Ge and Zheng Liu. Recent advancement of smart enzyme catalysts based on stimulus-responsive polymers. Chinese Polymer Bulletin, 2015, 9, 198−209. (Invited Review) [link]
18. Yifei Zhang, Jun Ge and Zheng Liu. Enhanced activity of immobilized or chemically modified enzymes. ACS Catalysis, 2015, 5, 4503−4513. (Invited Review, ESI highly cited paper) [link]
17. Zongjun Li, Yifei Zhang, Diannan Lu, Zheng Liu. Uniform mPEG-b-PMETAC enables pH-responsive delivery of insulin. Journal of Applied Polymer Science, 2015, 132, 42596. [link]
16. Xiaoling Wu, Jun Ge, Jingying Zhu, Yifei Zhang, You Yong, Zheng Liu. A general method for synthesizing enzyme-polymer conjugates in reverse emulsions using pluronic as a reactive surfactant. Chemical Communications, 2015, 51, 9674−9677. [link]
15. Rui Wang, Miao Hou, Yifei Zhang, Jun Ge, Zheng Liu. Enzymatic Synthesis of Lutein Dipalmitate in Organic Solvents. Catalysis Letters, 2015, 145, 995–999.
14. Fengjiao Lyu, Yifei Zhang, Richard N. Zare, Jun Ge, and Zheng Liu. One-pot synthesis of protein-embedded metal-organic frameworks with enhanced biological activities. Nano Letters, 2014, 14, 5761–5765. (ESI highly cited paper) [link]
13. Yifei Zhang, Fengjiao Lyu, Jun Ge, Zheng Liu. Ink-jet printing an optimal multi-enzyme system. Chemical Communications, 2014, 50, 12919−12922. (Highlighted by Chemical Communications Blog; Reported by news outlets such as The Conversation, Phys.org, Inkjet Wholesale News and etc.) [link]
12. Zhixian Li, Yifei Zhang, Yechao Su, Pingkai Ouyang, Jun Ge, Zheng Liu. Spatial co-localization of multi-enzymes by inorganic nanocrystal-protein complexes. Chemical Communications, 2014, 50, 12465–12468. [link]
11. Rui Wang, Yifei Zhang, Jun Ge, Zheng Liu. Activation of enzyme nanogel in organic solvents by PEG-substrate joint imprinting. RSC Advances, 2014, 4, 40301−40304. [link]
10. Xiaoling Wu, Rui Wang, Yifei Zhang, Jun Ge, Zheng Liu. Enantioselective ammonolysis of phenylglycine methyl ester with lipase–pluronic nanoconjugate in tertiary butanol. Catalysis Letters, 2014, 144, 1407−1410. [link]
9. Yifei Zhang, Qile Chen, Jun Ge and Zheng Liu. Controlled display of enzyme activity with a stretchable hydrogel. Chemical Communications, 2013, 49, 9815−9817. [link]
8. Yifei Zhang, Kehang Han, Diannan Lu and Zheng Liu. Reversible encapsulation of lysozyme within mPEG-b-PMAA: experimental observation and molecular dynamics simulation. Soft Matter, 2013, 9, 8723−8729. [link]
7. Yifei Zhang, Yang Dai, Miao Hou, Tian Li, Jun Ge, Zheng Liu. Chemo-enzymatic synthesis of valrubicin using pluronic conjugated lipase with temperature responsiveness in organic media. RSC Advances, 2013, 3, 22963−22966. [link]
6. Jingying Zhu, Yifei Zhang, Diannan Lu, Richard N. Zare, Jun Ge, and Zheng Liu. Temperature-responsive enzyme-polymer nanoconjugates with enhanced catalytic activities in organic media. Chemical Communications, 2013, 49, 6090−6092. [link]
5. Rui Wang, Yifei Zhang, Jinhai Huang, Diannan Lu, Jun Ge and Zheng Liu. Substrate imprinted lipase nanogel for one-step synthesis of chloramphenicol palmitate. Green Chemistry, 2013, 15, 1155−1158. [link]
4. Rui Wang, Yifei Zhang, Diannan Lu, Jun Ge, Zheng Liu, Richard N. Zare. Functional protein- organic/inorganic hybrid nanomaterials. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2013, 5, 320−328. [link]
3. Zhixian Li, Yifei Zhang, Pingkai Ouyang, Mengmeng Lin, Jun Ge, and Zheng Liu. Lipase-catalyzed one-step and regioselective synthesis of clindamycin palmitate. Organic Process Research & Development, 2013, 17, 1179−1182. [link]
2. Lin Zhu, Lu Gong, Yifei Zhang, Rui Wang, Jun Ge, Zheng Liu, Richard N. Zare. Rapid detection of phenol using a membrane containing laccase nanoflowers. Chemistry–An Asian Journal, 2013, 8, 2358−2360. [link]
1. Mengmeng Lin, Diannan Lu, Jingying Zhu, Cheng Yang, Yifei Zhang and Zheng Liu. Magnetic enzyme nanogel (MENG): a universal synthetic route for biocatalysts. Chemical Communications, 2012, 48, 3315−3317. [link]
Granted Patents
2. Yifei Zhang, Jun Ge, Zheng Liu. CN 103614425A. Method for catalytically synthesizing polyethylene glycol non-saturated carboxylate by utilizing lipase.
1. Zhixian Li, Jun Ge, Mengmeng Lin, Yifei Zhang, Diannan Lu, Zheng Liu. CN 103194511B. Method of lipase-catalyzed synthesis of fatty acid ester of clindamycin.