Publications

主要な研究業績（抜粋）

１ 原著論文(査読有)

1. Fujiki, S., Aoi, S., Funato, T., Sato, Y., Tsuchiya, K., and Yanagihara, D.: Adaptive hindlimb split-belt treadmill walking in rats by controlling basic muscle activation patterns via phase resetting. Scientific Reports 8, 17341 (2018).

2. Takeuchi, E., Ito-Ishida, A., Yuzaki, M., and Yanagihara, D.: Improvement of cerebellar ataxic gait by injecting Cbln1 into the cerebellum of cbln1-null mice. Scientific Reports 8, 6184 (2018).

3. Makii, Y., Asaka, M., Setogawa, S., Fujiki, S., Hosaka, Y., Yano, F., Oka, H., Tanaka, S., Fukui, N., Yanagihara, D., and Saito, T.: Alteration of gait parameters in a mouse model of surgically induced knee osteoarthritis. Journal of Orthopaedic Surgery 26, 1-7 (2018).

4. Funato, T., Sato, Y., Fujiki, S., Sato, Y., Aoi, S., Tsuchiya, K., and Yanagihara, D.: Postural control during quiet bipedal standing in rats. PLoS ONE 12(12): e0189248 (2017).

5. Shuvaev, A. N., Hosoi, N., Sato, Y., Yanagihara, D., and Hirai, H.: Progressive impairment of cerebellar mGluR signaling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice. Journal of Physiology 595(1), 141-164 (2017).

6. Kotajima-Murakami, H., Narumi, S., Yuzaki, M., and Yanagihara, D.: Involvement of GluD2 in fear-conditioned bradycardia in mice. PLoS ONE 11(11): e0166144 (2016).

7. Hoshino, D., Setogawa, S., Kitaoka, Y., Masuda, H., Tamura, Y., Hatta, H., and Yanagihara, D.: Exercise-induced expression of monocarboxylate transporter 2 in the cerebellum and its contribution to motor performance. Neuroscience Letters 633, 1-6 (2016).

8. Hagino, Y., Kasai, S., Fujita, M., Setogawa, S., Yamaura, H., Yanagihara, D., Hashimoto, M., Kobayashi, K., Meltzer, H., and Ikeda, K.: Involvement of cholinergic system in hyperactivity in dopamine-deficient mice. Neuropsychopharmacology 40, 1141-1150, (2015).

9. Setogawa, S., Yamaura, H., Arasaki, T., Endo, S., and Yanagihara, D.: Deficits in memory-guided limb movements impair obstacle avoidance locomotion in Alzheimer’s disease mouse model. Scientific Reports 4, 7220 (2014).

10. Aoki, S., Sato, Y., and Yanagihara, D.: Effect of inactivation of the intermediate cerebellum on overground locomotion in the rat: a comparative study of the anterior and posterior lobes. Neuroscience Letters 576, 22-27, (2014).

11. Kotajima, H., Sakai, K., Hashikawa, T., and Yanagihara, D.: Effects of inferior olive lesion on fear-conditioned bradycardia. NeuroReport 25, 556-561, (2014).

12. Koebis, M., Kiyatake, T., Yamaura, H., Nagano, K., Higashihara, M., Sonoo, M., Hayashi, Y., Negishi, Y., Endo-Takahashi, Y., Yanagihara, D., Matsuda, R., Takahashi, M. P., Nishino, I., and Ishiura, S. Ultrasound-enhanced delivery of morpholino with Bubble liposomes ameliorates the myotonia of myotonic dystrophy model mice. Scientific Reports 3, 2242 (2013).

13. Aoki, S., Sato, Y., and Yanagihara, D.: Lesion in the lateral cerebellum specifically produces overshooting of the toe trajectory in leading forelimb during obstacle avoidance in the rat. Journal of Neurophysiology 110(7), 1511-1524 (2013).

14. Yamaura, H., Hirai, H., and Yanagihara, D.: Postural dysfunction in a transgenic mouse model of spinocerebellar ataxia type 3. Neuroscience 243, 126-135 (2013).

15. Aoi, S., Kondo, T., Hayashi, N., Yanagihara, D., Aoki, S., Yamaura, H., Ogihara, N., Funato, T., Tomita, N., Senda, K., and Tsuchiya, K.: Contributions of phase resetting and interlimb coordination to the adaptive control of hindlimb obstacle avoidance during locomotion in rats: a simulation study. Biological Cybernetics 107(2), 201-216 (2013).

16. Takeuchi, E., Sato, Y., Miura, E., Yamaura, H., Yuzaki, M., and Yanagihara, D.: Characteristics of gait ataxia in δ2 glutamate receptor mutant mice, ho15J. PLoS ONE 7(10), e47553 (2012).

17. Aoki, S., Sato, Y., and Yanagihara, D.: Characteristics of leading forelimb movements for obstacle avoidance during locomotion in rats. Neuroscience Research 74(2), 129-137 (2012).

18. Sato, Y., Aoki, S., and Yanagihara, D.: Gait modification during approach phase when stepping over an obstacle in rats. Neuroscience Research 72(3), 263-269 (2012).

19. Nojima, J., Maeda, A., Aoki, S., Suo, S., Yanagihara, D., Watanabe, Y., Yoshida, T., and Ishiura, S.: Effect of rice-expressed amyloid β in the Tg2576 Alzheimer's disease transgenic mouse model. Vaccine 29(37), 6252-6258 (2011).

20. Kitsukawa, T., Nagata, M., Yanagihara, D., Tomioka, R., Utsumi, H., Kubota, Y., Yagi, T., Graybiel, A. M., and Yamamori, T.: A novel instrumented multipeg running wheel system, Step-Wheel, for monitoring and controlling complex sequential stepping in mice. Journal of Neurophysiology 106(1), 479-487 (2011).

21. Endo, S., Shutoh, F., Dinh, T. L., Okamoto, T., Ikeda, T., Suzuki, M., Kawahara, S., Yanagihara, D., Sato, Y., Yamada, K., Sakamoto, T., Kirino, Y., Hartell, N. A., Yamaguchi, K., Itohara, S., Nairn, A. C., Greengard, P., Nagao, S., and Ito, M.: Dual involvement of G-substrate in motor learning revealed by gene deletion. Proceedings of National Academy of Science USA 106, 3525-3530 (2009).

22. Kakizawa, S., Miyazaki, T., Yanagihara, D., Iino, M., Watanabe, M., and Kano, M.: Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain. Proceedings of National Academy of Science USA 102, 19180-19185 (2005).

23. Takayasu, Y., Iino M., Kakegawa, W., Maeno, H., Watase, K., Wada, K., Yanagihara, D., Miyazaki, T., Komine, O., Watanabe, M., Tanaka, K., and Ozawa, S.: Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses. Journal of Neuroscience 25, 8788-8793 (2005).

24. Hirai, H., Launey, T., Mikawa, S., Torashima, T., Yanagihara, D., Kasaura, T., Miyamoto, A., and Yuzaki, M.: New role of δ2-glutamate receptors in AMPA receptor trafficking and cerebellar function. Nature Neuroscience 6, 869-876 (2003).

25. Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto, R., Katsuki, M., and Aiba, A.: mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science 288, 1832-1835 (2000).

26. 伊藤 聡、湯浅秀男、羅 志偉、伊藤正美、柳原 大: 環境の変化に適応する四足歩行ロボットシステム. 日本ロボット学会誌 17, 595-603 (1999).

27. Ito, S., Yuasa, H., Luo, Z-W., Ito, M., and Yanagihara, D.: Adaptive locomotion to periodic perturbation. Adaptation mechanism with coupling of oscillator and link dynamics. Artificial Life and Robotics 3, 97-101 (1999).

28. Ito, S., Yuasa, H., Luo, Z-W., Ito, M., and Yanagihara, D.: A mathematical model of adaptive behavior in quadruped locomotion. Biological Cybernetics 78, 337-347 (1998).

29. Yanagihara, D. and Kondo, I.: Nitric oxide plays a key role in adaptive control of locomotion in cat. Proceedings of National Academy of Science USA 93, 13292-13297 (1996).

30. Yanagihara, D. and Udo, M.: Climbing fiber responses in cerebellar vermal Purkinje cells during perturbed locomotion in decerebrate cats. Neuroscience Research 19, 245-248 (1994).

31. Yanagihara, D., Udo, M., Kondo, I., and Yoshida, T.: A new learning paradigm: adaptive changes in interlimb coordination during perturbed locomotion in decerebrate cats. Neuroscience Research 18, 241-244 (1993).

32. Yanagihara, D., Watanabe, S., Takagi, S., and Mitarai, G.: Neuroanatomical substrate for the dorsal light response. II. Effects of kainic acid-induced lesions of the valvula cerebelli on the goldfish dorsal light response. Neuroscience Research 16, 33-37 (1993).

33. Yanagihara, D., Watanabe, S., and Mitarai, G.: Neuroanatomical substrate for the dorsal light response. I. Differential afferent connections of the lateral lobe of the valvula cerebelli in goldfish (Carassius auratus). Neuroscience Research 16, 25-32 (1993).

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２ 英文総説(査読有)

1. Yanagihara, D.: Role of the cerebellum in postural control. J. Phys. Fitness Sports Med. 3, 169-172, (2014).

2. Watanabe, S., Takabayashi, A., Tanaka, M., and Yanagihara, D.: Neurovestibular physiology in fish. Advances in Space Biology and Medicine 1, 99-128 (1991).

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３ 邦文総説

1. 柳原 大: 姿勢と歩行の制御における新たな小脳機能. Clinical Neuroscience 33, 763-766 (2015).

2. 柳原 大、竹内 絵理、山浦 洋、青木 祥: 歩行制御，姿勢制御における小脳機能の新知見. 体育の科学 64, 318-323 (2014).

3. 柳原 大: 運動オンチの謎を脳科学から探る‐運動の学習・記憶の神経生理学的メカニズム研究から. 体育科教育 59, 24-27 (2011).

4. 柳原 大: 歩行の制御における小脳機能. BRAIN and NERVE 62, 1149-1156 (2010).

5. 柳原 大: 歩行と小脳. Brain Medical 19, 349-358 (2007).

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４ 著書

1. 柳原 大、山浦 洋: 姿勢制御における小脳の役割. In : 宮村実晴 編, ニュー運動生理学Ⅰ, 真興交易（株）医書出版部, pp. 97-102, (2014).

2. 柳原 大: 歩行の制御における小脳機能. In : 大築立志、鈴木三央、柳原 大 編,歩行と走行の脳・神経科学‐その基礎から臨床まで‐. 市村出版, pp. 70-82, (2013).

3. 柳原 大: 運動におけるパターン生成の神経機構. In : 真鍋俊也、森 寿、渡辺雅彦、岡野栄之、宮川 剛 編, 改訂第3版脳神経科学イラストレイテッド‐分子・細胞から実験技術まで. 羊土社, pp. 235-241, (2013).

4. 柳原 大: 小脳における姿勢制御機構. In : 大築立志、鈴木三央、柳原 大 編, 姿勢の脳・神経科学‐その基礎から臨床まで‐. 市村出版, pp. 85-90, (2011).

5. 柳原 大: 適応的歩行における小脳の役割. In : 土屋和雄、高草木 薫、荻原直道 編, シリーズ移動知第2巻身体適応. オーム社, pp. 63-80, 97-102 (2010).

6. 柳原 大: 運動スキル、スキルトレーニングと小脳皮質. In : 宮村実晴 編, 身体トレーニング‐運動生理学からみた身体機能の維持・向上. 真興交易（株）医書出版部, pp. 30-39 (2009).

7. 柳原 大: 運動の学習・記憶と小脳長期抑圧. In : 西平賀昭、大築立志 編, 運動と高次神経機能. 杏林書院, pp. 180-189 (2005).

8. 柳原 大、饗場 篤、平井 宏和: 運動制御・運動学習のメカニズムをタンパク質・遺伝子レベルで探る. In : 柳原 大、内藤久士 編, 運動とタンパク質・遺伝子. ナップ, pp. 27-49 (2004).

9. 柳原 大: 小脳. In : 西野仁雄、柳原 大 編, 運動の神経科学. ナップ, pp. 32-49 (2000).

10. 柳原 大: 歩行運動. In : 甘利俊一、外山敬介 編, 脳科学大事典. 朝倉書店, pp. 317-319 (2000).

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５ 招待講演あるいはシンポジウム講演

国際会議、国内学会、シンポジウム等における招待講演（講演題目、会議名称、講演年月日、開催場所）

1. 歩行・姿勢の適応制御における小脳の役割. 第49回日本理学療法学術大会・神経理学療法研究部会・特別講演. 2014年6月1日. (国内学会、横浜).

2. Role of the cerebellum in adaptive control of posture and locomotion. Luncheon Seminar in 2^nd Joint World Congress of ISPGR and Gait & Mental Function. 2013年6月26日. (国際会議、秋田).

3. 運動の制御、学習・記憶、認知・予測における小脳皮質の役割. 運動生理学キーノートレクチャー. 日本体育学会第61回大会. 2010年9月8日. (国内学会、愛知).

4. 脳と運動・スポーツ‐運動が脳を育てる‐. 第４７回全国学校体育研究大会. ２００８年１０月３０日. (国内会議、岩手).

5. 運動スキルの脳神経科学‐適応制御に関わる小脳機能‐. ロボティクス・メカトロニクス講演会２００８、チュートリアル「認知から運動や行動の発現へ」.２００８年６月５日. (国内学会、長野).

6. Role of the cerebellum in adaptive control of locomotion. SICE-ICASE International Conference 2006. ２００６年１０月２１日. (国際会議、Busan, Korea).

7. 歩行の自己組織化における小脳の役割. 第２１回日本神経科学・第４１回日本神経化学合同大会. １９９８年９月２１日. (国内学会、東京).

8. Neural mechanisms of learning locomotion dynamics. 第１回理化学研究所脳科学総合研究センター・マサチューセッツ工科大学共同国際シンポジウム「脳科学における挑戦」. １９９８年４月２８日. (国際会議、埼玉).

9. Mouse mutants as a tool in studies of cerebellar motor control. The Eight Annual Meeting of Neural Control of Movement. １９９８年４月１５日. (国際学会、Key West, USA).

10. Involvement of cerebellar synaptic plasticity in adaptive control of locomotion of the decerebrate cat. 13^th International Symposium Multisensory Control of Posture and Gait. １９９７年６月２４日. (国際学会、Paris, France).

11. Role of cerebellar synaptic plasticity in adaptive control of locomotion in cats. Fourth IBRO World Congress of Neuroscience. １９９５年７月１４日. (国際学会、京都).

12. Role of nitric oxide in cerebellar motor learning – adaptation to perturbed locomotion in cats. Japan-Israel Joint Meeting in Neuroscience: Recent developments and future perspectives in studies of brain mechanisms. １９９４年１２月１４日. (国際会議、Eilat, Israel).

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