Research

• Publications

Major work

Methodology of Epidemiology and Biostatistics

1. Yan-Lin Chen, Yun-Hao Chang, Sheng-Hsuan Lin* (2026). Targeted maximum likelihood estimation for mediation analysis with multiple time-varying mediators. Biometrics. (Accepted for publication)

2. Yan-Lin Chen, Hsiang-Hsi Hung, Sheng-Hsuan Lin* (2026). Sensitivity bounds for bias in hazard ratios: A causal hazard perspective. Statistical Methods in Medical Research. (In press) [link]

3. Yan-Lin Chen, Tsung Yu, Sheng-Hsuan Lin* (2026). Causal mediation analysis with mediator-outcome confounders affected by exposure: On definition and identification of generalized natural indirect effect. Epidemiology, 37(1), 21-29. [link]

4. Yan-Lin Chen, Sheng-Hsuan Lin* (2025). Definition and interpretation of separable path-specific effects with multiple ordered mediators. Epidemiology, 36(5), 677-685. [link]

5. Yan-Lin Chen, Yan-Hong Chen, Pei-Fang Su, Huang-Tz Ou, An-Shun Tai* (2024). Robust inference for causal mediation analysis of recurrent event data. Statistics in Medicine, 43(16), 3020-3035. [link]

Collaborative work

Medical Microbiome Analysis

6. Sheng-Hsuan Lin, Ru-Jen Lin, Ruey-Yi Chang, Yu-Fang Huang, Yi-Yung Hsu, Chia-Ling Chu, Yan-Lin Chen, Chong-You Lin, Shih-Chen Fu* (2026). Heterogeneity in the association between gut microbiota and insomnia moderated by Parkinson's disease status. Frontiers in Cellular and Infection Microbiology, 16, 1691665. [link]

7. Jung-Chi Chang, Yu-Chieh Chen, Hai-Ti Lin, Yan-Lin Chen, Shur-Fen Gau* (2026). Identifying gut microbiota composition disparities in autistic individuals and their unaffected siblings: Correlations with clinical characteristics. Translational Psychiatry, 16, 43. [link]

8. Sheng-Hsuan Lin, Ru-Jen Lin, Chia-Ling Chu, Yan-Lin Chen, Shih-Chen Fu* (2025). Associations between gut microbiota composition and impulse control disorders in Parkinson’s disease. International Journal of Molecular Sciences, 26(13), 6146. [link]

9. Sheng-Hsuan Lin, Ru-Jen Lin, Kai-Yu Chan, Chia-Ling Chu, Yan-Lin Chen, Shih-Chen Fu* (2025). Anxiety-related gut microbiota alterations in Parkinson’s disease: distinct associations compared to healthy individuals. Frontiers in Cellular and Infection Microbiology, 15, 1594152. [link]

10. Ling-Chieh Shih, Ru-Jen Lin, Yan-Lin Chen, Shih-Chen Fu* (2024). Unravelling the mechanisms of underweight in Parkinson’s disease by investigating into the role of gut microbiome. npj parkinson's disease, 10(1), 28. [link]

Others

11. Shao Yu Hung, Curtis Hanba, Tommy Nai-Jen Chang, Yan-Lin Chen, Johnny Chuieng-Yi Lu* (2024). Delayed commissuroplasty increases interincisal distance in buccogingival cancer patients treated with free flap reconstruction of the oral commissure. Journal of Reconstructive Microsurgery, 40(9), 707-712. [link]