Publications

 Xiao X, Babitt JL. A tale of two transferrin receptors. Commentary. 2026. Blood 147(19):2166-2168. 

Xiao X#, Moschetta GA, Chowdhury SB, Phillips S, Ghatpande N, Fisher AL, Xue Y, Babitt JL. Hemochromatosis Proteins HJV and HFE in BMP-Mediated Hepcidin Regulation and Iron Homeostasis. 2025. American Journal of Hematology 100(12):2175-2184. #Corresponding author.

Fisher AL, Phillips S, Wang CY, Paulo JA, Xiao X, Xu Y, Moschetta GA, Xue Y, Mancias JD, Babitt JL. The hepcidin-ferroportin axis modulates liver endothelial cell BMP expression to influence iron homeostasis in mice. 2025. Blood 145(6):625-634. 

Fisher AL, Phillips S, Wang CY, Paulo JA, Xiao X, Moschetta GA, Sridhar A, Mancias JD, Babitt JL. Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice. 2024. Blood 143(23):2433-2437. 

Xiao X, Xu Y, Moschetta GA, Yu Y, Fisher AL, Alfaro-Magallanes VM, McMillen S, Phillips S, Wang CY, Christian J, Babitt JL. BMP5 contributes to hepcidin regulation and systemic iron homeostasis in mice. 2023. Blood 142(15):1312-1322. 

Xiao X, Moschetta GA, Xu Y, Fisher AL, Alfaro-Magallanes VM, Dev S, Wang CY, Babitt JL. Regulation of iron homeostasis by hepatocyte TFR1 requires HFE and contributes to hepcidin suppression in β-thalassemia. 2023. Blood 141(4):422-432.

Fisher AL, Wang CY, Xu Y, Phillips S, Paulo JA, Małachowska B, Xiao X, Fendler W, Mancias JD, Babitt JL. Quantitative proteomics and RNA-sequencing of mouse liver endothelial cells identify novel regulators of BMP6 by iron. 2023. iScience 26(12):108555.

Fisher AL, Wang CY, Xu Y, Joachim K, Xiao X, Phillips S, Moschetta GA, Alfaro-Magallanes VM, Babitt JL. Functional role of endothelial transferrin receptor 1 in iron sensing and homeostasis. 2022. American Journal of Hematology 97(12):1548-1559.

Yeoh BS, Saha P, Golonka RM, Zou J, Petrick JL, Abokor A, Xiao X, Bovilla VR, Bretin ACA, Rivera-Esteban J, Parisi D, Florio AA, Weinstein SJ, Albanes D, Freeman GJ, Gohara AF, Ciudin A, Pericàs JM, Joe B, Schwabe RF, McGlynn KA, Gewirtz AT, Vijay-Kumar M. Enterohepatic shunt-drive cholemia predisposes to liver cancer. 2022. Gastroenterology 163(6):1658-1671.e16.

Saha P, Yeoh BS, Xiao X, Golonka RM, Wenceslau C, Joe B, and Vijay-Kumar M. 2020. Enterobactin induces the chemokine, interleukin-8, from intestinal epithelia by chelating intracellular iron. Gut microbes 12(1):1-18.

Xiao X, Alfaro-Magallanes VM, Babitt JL. 2020. Bone morphogenic proteins in iron homeostasis. Bone 138:115495.

Saha P*, Xiao X*, Li Y, Golonka RM, Abokor A, Yeoh BS, Vijay-Kumar M. 2020. Distinct iron homeostasis in C57BL/6 and Balb/c mouse strains. Physiol Reports 8(9):e14441* Co-first author.

Li Y, Wei CH, Xiao X, Green, MH, Ross AC. 2020. Perturbed vitamin A status induced by iron deficiency was corrected by iron repletion in rats with preexisting iron deficiency. J Nutr 150(7):1989-1995

Xiao X, Dev S, Canali S, Bayer A, Yang X, Wang CY, Babitt JL. 2020. Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice. Hepatology 72(2):642-655

Golonka RM, Xiao X, Abokor A, Joe B, Vijay-Kumar M. 2020. Altered Nutrient Status Reprograms Host Inflammation and Metabolic Health via Gut Microbiota. J Nutr Biochem. 

Wang CY, Yang X, Traeger L, Dogan D, Xiao X, Steinbicker AU, and Babitt JL. 2019. Erythroferrone binds BMP2/6 heterodimer and mediates hepcidin suppression via ALK3 in mice. Blood 135(6):453-456

Golonka RM, Yeoh BS, Li Y, Saha P, Abokor A, Cheng X, Xiao X, Chandrashekar D, Varambally S, Gonzalez D, Ross AC, Vijay-Kumar M. 2020. Fermentable Fibers Induce Rapid Macro and Micronutrient Depletion in Toll-like Receptor 5 Deficient Mice. Am J Physiol Gastrointest Liver Physiol 318(5):G955-G965

Wang CY, Xiao X, Bayer A, Dev S, Canali S, Nair AV, Masia R, Babitt JL. 2019. Ablation of hepatocyte Smad1, Smad5, and Smad8 causes severe tissue iron loading and liver fibrosis in mice. Hepatology 70(6):1986-2002

Saha P, Yeoh BS, Xiao X, Golonka RM, Kumarasamy S, Vijay-Kuamr M. 2019. Enterobactin, an Iron Chelating Bacterial Siderophore, Arrests Cancer Cell Proliferation. Biochemical Pharmacology 168:71-81

Saha P, Yeoh BS, Xiao X, Golonka RM, Wang Y, Vijay-Kuamr M. 2019. Peptidyl arginine deiminase-4 deficiency aggravates Citrobacter rodentium infection and the associated intestinal inflammation. Mucosal Immunology 12(3):761-771

Singh V, Yeoh BS, Walker RE, Xiao X, Saha P, Golonka RM, Cai J, Bretin ACA, Cheng X, Liu Q, Flythe MD, Chassaing B, Shearer GC, Patterson AD, Gewirtz AT, Vijay-Kumar M. 2019. Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibers on intestinal inflammation. Gut 68(10):1801-1812

Saha P, Xiao X, Yeoh BS, Chen Q, Katkere B, Soorappa G, Vijay-Kuamr M. 2019. The bacterial siderophore enterobactin confers survival advantage to Salmonella by limiting macrophage innate immune responses. Gut Microbes 10(3):412-423

Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Olvera RA, Lapek JD, Zhang L, Wang WB, Hao S, Flythe MD, Gonzalez DJ, Cani PD, Conejo-Garcia JR, Xiong N, Kennett MJ, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M. 2018. Dysregulated gut microbial fermentation of soluble fiber and bile acid metabolism induces hepatocellular carcinoma in mice. Cell 175(3) :679-694.e22

Xiao X, Saha P, Yeoh BS, Singh V, Hipp AJ, Vijay-Kumar M. 2018. Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects. J Nutr Biochem 62:28-34

Saha P, Yeoh BS, Olvera RA, Xiao X, Singh V, Awasthi D, Subramanian BC, Chen Q, Dikshit M, Wang Y, Parent CA, Vijay-Kumar M. 2017. Bacterial Siderophores Hijack Neutrophil Functions. J Immunol 198: 4293-303

Xiao X, Yeoh BS, Vijay-Kumar M. 2017. Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation. Annu Rev Nutr 37: 103-30

Saha P, Chassaing B, Yeoh BS, Viennois E, Xiao X, Kennett MJ, Singh V, Vijay-Kumar M. 2017. Ectopic Expression of Innate Immune Protein, Lipocalin-2, in Lactococcus lactis Protects Against Gut and Environmental Stressors. Inflamm Bowel Dis 23: 1120-32.

Xiao X, Yeoh BS, Saha P, Tian Y, Singh V, Patterson AD, Vijay-Kumar M. 2017. Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice. J Nutr Biochem 41: 25-33

Charepalli V, Reddivari L, Radhakrishnan S, Eriksson E, Xiao X, Kim SW, Shen F, Vijay-Kumar M, Li Q, Bhat VB, Knight R, Vanamala JKP. 2017. Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance. Cancer Prev Res (Phila) 10: 442-50

Yeoh BS, Saha P, Singh V, Xiao X, Ying Y, Vanamala JK, Kennett MJ, Harvatine KJ, Joe B, Vijay-Kumar M. 2016. Deficiency of stearoyl-CoA desaturase-1 aggravates colitogenic potential of adoptively transferred effector T cells. Am J Physiol Gastrointest Liver Physiol 311: G713-G23

Yeoh BS, Aguilera Olvera R, Singh V, Xiao X, Kennett MJ, Joe B, Lambert JD, Vijay-Kumar M. 2016. Epigallocatechin-3-Gallate Inhibition of Myeloperoxidase and Its Counter-Regulation by Dietary Iron and Lipocalin 2 in Murine Model of Gut Inflammation. Am J Pathol 186: 912-26

Singh V, Yeoh BS, Chassaing B, Zhang B, Saha P, Xiao X, Awasthi D, Shashidharamurthy R, Dikshit M, Gewirtz A, Vijay-Kumar M. 2016. Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis. Cell Mol Gastroenterol Hepatol 2: 482-98 e6

Xiao X, Yeoh BS, Saha P, Olvera RA, Singh V, Vijay-Kumar M. 2016. Lipocalin 2 alleviates iron toxicity by facilitating hypoferremia of inflammation and limiting catalytic iron generation. Biometals 29: 451-65

Singh V, Kumar M, San Yeoh B, Xiao X, Saha P, Kennett MJ, Vijay-Kumar M. 2016. Inhibition of Interleukin-10 Signaling Induces Microbiota-dependent Chronic Colitis in Apolipoprotein E Deficient Mice. Inflamm Bowel Dis 22: 841-52