Lee WH, Shen YR, Huang BC, Ho KW, Chen CK, Wu HH, Hsieh YH, Lu YC, Cheng YA, Lee YC, Hong ST, Liao TY, Chang CC, Liu LY, Yang MC, Chang TH, Cheng TL, Chen YY*, Lin WW*. Protease-Activated Anti-Lewis Y Antibody Enhances Selectivity and Safety of Glycan-Targeting Cancer Therapy. Int J Biol Macromol. 2025 May;309(Pt 4):143176. 2024 SCI IF: 8.5 (6/94, 6.4% in Polymer Science). Link: https://pubmed.ncbi.nlm.nih.gov/40246093/

Chang MS#, Lee CY#, Chang YY, Li PJ, Wu HY, Liu ES, Huang HK, Lin WW*. Genetically engineered secretory horseradish peroxidase is a sensitive, stable, and affordable non-lytic reporter gene system for real-time promoter activity management. J Biol Eng. 2025 Apr 22;19(1):37. 2024 SCI IF: 6.5 (5/86, 5.8% in Biochemical research methods). Link: https://pubmed.ncbi.nlm.nih.gov/40264227/

Chang MS, Lee CY, Wu HY, Wang YT, Chao H, Chang YY, Liu ES, Huang HK, Lin WW*. A dual-structured chromogenic enzyme platform for a rapid, sensitive, durable and precise gene expression analysis. Anal. Chem. 2025 Feb 25;97(7):3872-3880. 2024 SCI IF: 6.7 (10/111, 9.0% in Chemistry, Analytical). Link: https://pubmed.ncbi.nlm.nih.gov/39939281/

Liao TY#, Liu YL#, Chen CY, Wu BT, Liu ES, Hong ST, Huang BC, Cheng YA, Chen M, Chuang KH, Lin WW, Chuang CH, Chen FM, Ho KW*, Cheng TL*. Development of a tumor-region-selective activation monoclonal antibody targeting the 4-1BB receptor for enhanced therapeutic efficacy and safety. Int J Biol Macromol. 2025 May;305(Pt 2):141003. 2024 SCI IF: 8.5 (6/94, 6.4% in Polymer Science). Link: https://pubmed.ncbi.nlm.nih.gov/39978521/

Meng JL, Dong ZX, Chen YR, Lin MH, Liu YC, Roffler SR, Lin WW, Chang CY, Tzou SC, Cheng TL, Huang HC, Li ZQ, Lin YC, Su YC*. pH-responsive polyethylene glycol engagers for enhanced brain delivery of PEGylated nanomedicine to treat glioblastoma. ACS Nano. 2025 Jan 14;19(1):307-321. 2024 SCI IF: 16.0 (28/460, 6.1% in Materials science, Multidisciplinary). Link: https://pubmed.ncbi.nlm.nih.gov/39749925/

Chen YW, Liu RY, Shih MK, Lin WW, Cheng CM, Hsieh CW, Hou CY,*, Chen SY*. The monomer of resveratrol butyrate ester ameliorates obesity and gut microbiota in high-fat diet rats. Journal of Functional Foods. 2024 May 31;106260 2023 SCI IF: 3.8 (35/114, 30.7% in Nutrition, Dietetics). Link: https://www.sciencedirect.com/science/article/pii/S1756464624002627

Chang MS, Lee CY, Liu ES, Chao H, Wu HY, Chang YY, Liu YL, Chen YT, Su YC, Wang YT, Cheng TL, Yen CH, Lin CW, Huang HK*, Lin WW*. A low-cost, sensitive reporter system using membrane-tethered horseradish peroxidase for efficient gene expression analysis. Anal. Chem. 2023 Sep 26;95(38):14341-14349. 2022 SCI IF: 7.4 (7/86, 8.1% in Chemistry, Analytical)  Link: https://pubmed.ncbi.nlm.nih.gov/37715702/

Lin WW#, Huang YJ#, Wang YT, Lin YS, Mazibuko N, Chen CS, Cheng TL, Chang CS, Leu YL, Chen CY, Chuang CH*. Development of NS2B-NS3 protease inhibitor that impairs Zika virus replication. Virus Res. 2023 May;329:199092. 2022 SCI IF: 5.0 (13/36, 36.1% in Virology)  Link: https://pubmed.ncbi.nlm.nih.gov/36965673/

Jiang FY#, Zhang YZ#, Tai YH#, Chou CY, Hsieh YC, Chang YC, Huang HC, Li ZQ, Hsieh YC, Chen IJ, Huang BC, Su YC, Lin WW, Lin HC, Chao JI, Yuan SSF, Wang YM, Cheng TL and Tzou SC. A lesion‑selective albumin‑CTLA4Ig as a safe and effective treatment for collagen‑induced arthritis. Inflamm Regen. 2023 Feb 16;43(1):13. 2022 SCI IF: 8.1 (20/136, 14.7% in Medicine, Research & Experimental). Link: https://pubmed.ncbi.nlm.nih.gov/36797799/

Hsiao CY#, Meng JL#, Hong JZ, Ly XH, Lin MH, Chang CY, Minh-Tram T Nguyen, Cheng TL, Lin WW, Pierre-Alain Burnouf, Talal Salem Al-Qaisi, Liu ES, Su YC*. Engineering a high-affinity anti-methoxy poly(ethylene glycol) (mPEG) antibody for sensitive immunosensing of mPEGylated therapeutics and mPEG molecules. Bioconjug Chem. 2022 Nov 16;33(11):2180-2188. 2021 SCI IF: 6.069 (11/79, 13.9% in Biochemical Research Methods). Link: https://pubmed.ncbi.nlm.nih.gov/36320124/

Chuang CH, Cheng TL, Chen WC, Huang YJ, Wang HE, Lo YC, Hsieh YC, Lin WW, Hsieh YJ, Ke CC, Huang KC, Lee JC, Huang MY*. Micro-PET imaging of hepatitis C virus NS3/4A protease activity using a protease-activatable retention probe. Front Microbiol. 2022 Nov 4;13:896588. 2021 SCI IF: 6.064 (34/137, 24.8% in Microbiology). Link: https://pubmed.ncbi.nlm.nih.gov/36406412/

Wang YT*, Liao JM, Lin WW, Li CC, Huang BC, Cheng TL, Chen  TC. Structural insights into Nirmatrelvir (PF-07321332)-3C-like SARS-CoV-2 protease complexation: a ligand Gaussian accelerated molecular dynamics study. Phys Chem Chem Phys. 2022 Sep 28;24(37):22898-22904. 2021 SCI IF: 3.945 (9/36, 25% in Physics, Atomic, Molecular & Chemical). Link: https://pubmed.ncbi.nlm.nih.gov/36124909/

Minh-Tram T Nguyen#, Shih YC#, Lin MH#, Roffler SR, Hsiao CY, Cheng TL, Lin WW, Lin EC, Jong YJ, Chang CY*, Su YC*. Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group. Commun Chem. 2022 Aug 1; 5(1): 88. 2021 SCI IF: 7.211 (43/179, 24% in Chemistry, Multidisciplinary). Link: https://pubmed.ncbi.nlm.nih.gov/35936993/

Cheng KW, Tseng CH, Chen IJ, Huang BC, Liu HJ, Ho KW, Lin WW, Chuang CH, Huang MY, Leu YL, Roffler SR, Wang JY, Chen YL, Cheng TL*. Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis. Pharmacol Res. 2022 Feb 3;177: 106115. 2021 SCI IF: 10.334 (15/279, 5.4% in Pharmacology & Pharmacy). Link: https://pubmed.ncbi.nlm.nih.gov/35124207/

Lin WW*, Ho KW, Su HH, Fang TF, Tzou SC, Chen IJ, Lu YC, Chang MS, Tsai YC, Liu ES, Su YC, Wang YT, Cheng TL, Huang HK*. Fibrinogen-like protein 1 serves as an anti-inflammatory agent for collagen-induced arthritis therapy in mice. Front. Immunol. 2021 Dec 16;12:767868. 2020 SCI IF: 7.561 (24/162, 14.81% in Immunology). Link: https://pubmed.ncbi.nlm.nih.gov/34975855/

Lin WW, Lu YC, Huang BC, Chuang CH, Cheng YA, Chen IJ, Liu HJ, Ho KW, Liao TY, Liu ES, Wu TY, Chang LS, Hong ST*, Cheng TL*. Selective activation of pro-anti-IL-1β antibody enhances specificity for autoinflammatory disorder therapy. Sci Rep. 2021 Jul 21;11(1):14846. 2020 SCI IF: 4.379 (17/73, 23.28% in Multidisciplinary sciences). Link: https://pubmed.ncbi.nlm.nih.gov/34290297/

Lin WW, Cheng YA, Li CC, Ho KW, Chen HJ, Chen IJ, Huang BC, Liu HJ, Lu YC, Cheng CM, Huang MY, Lai HW*, Cheng TL*. Enhancement of tumor tropism of mPEGylated nanoparticles by anti-mPEG bispecific antibody for ovarian cancer therapy. Sci Rep. 2021. Apr 7;11(1):7598. 2020 SCI IF: 4.379 (17/73, 23.28% in Multidisciplinary sciences). Link: https://pubmed.ncbi.nlm.nih.gov/33828191/

Lin WW, Wang YJ, Ko CW, Cheng TL, Wang YT*. Cyclic peptide inhibitors of the Tsg101 UEV protein interactions refined through global docking and gaussian accelerated molecular dynamics simulations. Polymers (Basel). 2020 Sep 28;12(10):E2235. 2019 SCI IF: 3.426 (16/89, 17.9% in Polymer Science). Link: pubmed.ncbi.nlm.nih.gov/32998394/ 

Lin WW, Lu YC, Chuang CH, Cheng TL*. Ab locks for improving the selectivity and safety of antibody drugs. J Biomed Sci. 2020 Jun 25;27(1):76. 2019 SCI IF: 5.762 (17/138, 12.3% in Medicine, Research & Experimental). Link: https://pubmed.ncbi.nlm.nih.gov/32586313/ 

Chen IJ, Cheng YA, Ho KW, Lin WW, Cheng KW, Lu YC, Hsieh YC, Huang CC, Chuang CH, Chen FM, Su YC, Roffler SR*, Cheng TL*. Bispecific antibody (HER2 × mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes. Acta Biomater. 2020 May 14;S1742-7061(20)30226-9. 2019 SCI IF: 7.242 (8/87, 9.2% in Engineering, Biomedical). Link: https://pubmed.ncbi.nlm.nih.gov/32417267/ 

Chang TC, Chen BM, Lin WW, Yu PH, Chiu YW, Chen YT, Wu JY, Cheng TL, Hwang DY*, Roffler SR*. Both IgM and IgG antibodies against polyethylene glycol can alter the biological activity of methoxy polyethylene glycol-epoetin beta in mice. Pharmaceutics. 2019 Dec 21;12(1):15. 2018 SCI IF: 4.773 (26/267, 9.73% in Pharmacology & Pharmacy). Link: https://pubmed.ncbi.nlm.nih.gov/31877813/ 

Huang CC, Cheng KW, Hsieh YC, Lin WW, Cheng CM, Yuan SS, Chen IJ, Cheng YA, Huang BC, Lu YC, Tung YC*, Cheng TL*. Use of syngeneic cells expressing membrane-bound GM-CSF as an adjuvant to induce antibodies against native multi-pass transmembrane protein. Sci Rep. 2019 Jul 9;9(1):9931. 2018 SCI IF: 4.011 (15/69, 21.74% in Multidisciplinary sciences). Link: https://pubmed.ncbi.nlm.nih.gov/31289297/ 

Cheng YA, Chen IJ, Su YC, Cheng KW, Lu YC, Lin WW, Hsieh YC, Kao CH, Chen FM, Roffler SR*, Cheng TL*. Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer. Biomater Sci. 2019 Aug 1;7(8):3404-3417. 2018 SCI IF: 5.251 (5/32, 15.63% in Materials Science, Biomaterials). Link: https://pubmed.ncbi.nlm.nih.gov/31251311/ 

Lu YC, Chuang CH, Chuang KH, Chen IJ, Huang BC, Lee WH, Wang HE, Li JJ, Cheng YA, Cheng KW, Wang JY, Hsieh YC, Lin WW*, Cheng TL*. Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy. PLoS Biol. 2019 Jun 13;17(6):e3000286. 2018 SCI IF: 8.386 (3/87, 3.45% in Biology). Link: https://pubmed.ncbi.nlm.nih.gov/31194726/ 

Hsieh YC, Wang HE, Lin WW, Roffler SR, Cheng TC, Su YC, Li JJ, Chen CC, Huang CH, Chen BM, Wang JY, Chen FM*, Cheng TL*. Pre-existing anti-polyethylene glycol antibody reduces the therapeutic efficacy and pharmacokinetics of PEGylated liposomes. Theranostics. 2018 May 9;8(11):3164-3175. 2017 SCI IF: 8.537 (8/133, 6.02% in Medicine, Research & Experimental). Link: https://pubmed.ncbi.nlm.nih.gov/29896310/  

Chen IJ, Chuang CH, Hsieh YC, Lu YC, Lin WW, Huang CC, Cheng TC, Cheng YA, Cheng KW, Wang YT, Chen FM, Cheng TL*, Tzou SC*. Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains. Sci Rep. 2017 Sep 14;7(1):11587. 2016 SCI IF: 4.259 (10/64, 15.6% in Multidisciplinary sciences). Link: https://pubmed.ncbi.nlm.nih.gov/28912497/ 

Lin WW, Cheng YA, Kao CH, Roffler SR, Lee YC, Chen BM, Hsieh YC, Chen IJ, Huang BC, Wang YT, Tung YC, Huang MY, Chen FM*, Cheng TL*. Enhancement effect of a variable topology of a membrane-tethered anti-poly(ethylene glycol) antibody on the sensitivity for quantifying PEG and PEGylated molecules. Anal. Chem. 2017 Jun 6; 89(11):6082-6090. 2016 SCI IF: 6.320 (4/76, 5.3% in Chemistry, Analytical). Link: https://pubmed.ncbi.nlm.nih.gov/28485140/ 

Chuang CH, Wu PC, Tsai TH, Fang YP, Tsai YH, Cheng TC, Huang CC, Huang MY, Chen FM, Hsieh YC, Lin WW, Tsai MJ, Cheng TL*. Development of pH-sensitive cationic PEGylated solid lipid nanoparticles for selective cancer-targeted therapy. Journal of Biomedical Nanotechnology. 2017 Fab. 13; 2. 192-203(12). 2016 SCI IF: 4.521 (7/33, 21.21% in Materials Science, Biomaterials). Link: https://pubmed.ncbi.nlm.nih.gov/29377649/ 

Lin WW, Hsieh YC, Cheng YA, Chuang KH, Huang CC, Chuang CH, Chen IJ, Cheng KW, Lu YC, Cheng TC, Wang YT, Roffler SR*, Cheng TL*. Optimization of an anti-poly(ethylene glycol) (anti-PEG) cell-based capture system to quantify PEG and PEGylated molecules. Anal. Chem. 2016 Dec 20;88(24):12371-12379. 2015 SCI IF: 5.886 (4/75, 5.3% in Chemistry, Analytical). Link: https://pubmed.ncbi.nlm.nih.gov/28193011/ 

Hsieh YC, Cheng TC, Wang HE, Li JJ, Lin WW, Huang CC, Chuang CH, Wang YT, Wang JY, Roffler SR, Chuang KH*, Cheng TL*. Using anti-poly(ethylene glycol) bioparticles for the quantitation of PEGylated nanoparticles. Sci Rep. 2016 Dec 19;6:39119. 2015 SCI IF: 5.228 (7/63, 11.1% in Multidisciplinary sciences). Link: https://pubmed.ncbi.nlm.nih.gov/27991598/ 

Lin WW, Chen IJ, Cheng TC, Tung YC, Chu PY, Chuang CH, Hsieh YC, Huang CC, Wang YT, Kao CH, Roffler SR*, Cheng TL*. A secondary antibody-detecting molecular weight marker with mouse and rabbit IgG Fc linear epitopes for Western Blot analysis. PLoS One. 2016 Aug 5;11(8):e0160418. 2015 SCI IF: 3.057 (11/63, 17.5% in Multidisciplinary sciences). Link: https://pubmed.ncbi.nlm.nih.gov/27494183/ 

Chuang KH, Hsieh YC, Chiang IS, Chuang CH, Kao CH, Cheng TC, Wang YT, Lin WW, Chen BM, Roffler SR, Huang MY*, Cheng TL*. High-throughput sorting of the highest producing cell via a transiently protein-anchored system. PLoS One. 2014 Jul 18;9(7):e102569. 2013 SCI IF: 3.534 (8/55, 14.5% in Multidisciplinary sciences). Link: https://pubmed.ncbi.nlm.nih.gov/25036759/ 

Lin CW, Liao MY, Lin WW, Wang YP, Lu TY, Wu HC*. Epithelial cell adhesion molecule regulates tumor initiation and tumorigenesis via activating reprogramming factors and epithelial-mesenchymal transition gene expression in colon cancer. J Biol Chem. 2012 Nov 16;287(47):39449-59. 2011 SCI IF: 4.773 (66/290, 22.8% in Biochemistry & Molecular biology). Link: https://pubmed.ncbi.nlm.nih.gov/22989882/