Research

Our lab develops and applies 3D neural organoid systems, with a particular focus on human spinal cord organoids. These systems allow us to recapitulate neural tube morphogenesis, large-scale tissue patterning, and functional network activity. We utilize these physiologically relevant platforms to investigate human-specific developmental processes and disease mechanisms, including neural tube defects, and to facilitate drug screening applications.

We are also dedicated to advancing methodological capabilities through the creation of cutting-edge histological and imaging tools. Key innovations include multiplex immunohistochemistry reagents and tissue clearing strategies. By facilitating the detailed visualization of complex neural tissues, these technologies serve as powerful platforms for high-throughput analysis in both basic and translational research.

Mitochondrial structural dynamics play a pivotal role in cellular survival and homeostasis. Our lab conducts fundamental research to understand the regulation of these dynamics and their association with various diseases. Specifically, we aim to precisely analyze the impact of mitochondrial dynamics on the development of the nervous system.