We are actively recruiting highly motivated post-doctoral fellows, bioinformaticians, students, interns to join our group.
Research Officer
Job summary
We are seeking an a highly motivated and innovative Bioinformatician/Data Scientist with a background in AI and Machine Learning to drive integration of diverse multi-omics and clinical data related to various diseases, including ophthalmology, cancer, metabolic and skin diseases. The successful candidate will manage large-scale multimodal data, analyze large-scale biological datasets, and contribute to the discovery of biomarkers, therapeutic targets, and understanding of complex biological systems.
Key Responsibilities
Curate incoming large-scale multi-omics (genomics, transcriptomics, proteomics, metabolomics, lipidomics), images and clinical data
Build data management and database solutions to manage and integrate complex datasets with compliance to data security requirements
Implement, benchmark and execute analysis workflows for high-throughput sequencing and omics datasets to identify patterns and insights
Visualize and build dashboards to communicate complex data outputs for scientific and
clinical applications
Optimize algorithms for speed, accuracy, and scalability in cloud or HPC environments
Develop AI-powered pipelines for image analysis, data integration, feature extraction, and predictive modeling
Implement international data standards and FAIR (Findability, Accessibility, Interoperability, and Reusability) principles
Collaborate with research teams and clinicians to translate biological and clinical questions into computational solutions
Stay updated with advancements in AI, bioinformatics, and computational biology
Qualifications
Bachelor’s or Master’s degree in Bioinformatics, Computational Biology, Data Science, Computer Science, Health Informatics, or related field
Strong programming skills in Python, R, or similar languages, with experience in AI frameworks such as TensorFlow, PyTorch, Scikit-learn
Knowledge of biological concepts, genomics, transcriptomics, or other 'omics' disciplines
Familiarity with data visualization tools and database development
Experience with Unix/Linux, HPC environments and cloud platforms, and large dataset processing
Preferred Skills
Knowledge of biological databases and data standards
Excellent communication, presentation and collaboration skills
Strong analytical and problem-solving skills, and attention to detail
Able to work independently, with competent project management and organizational skills
Experience in mining and analyzing public omics datasets
Computational Scientist - Multimodal AI & Data Integration (Metabolic Disease)
Position summary
We are seeking a highly motivated Computational Scientist with expertise in artificial intelligence, multi-omics data integration, and metabolic disease biology . The successful candidate will play a critical role in developing AI/ML frameworks to integrate and analyze high-dimensional biological datasets (e.g. genomics, transcriptomics, proteomics, imaging) with clinical data to identify novel mechanisms, biomarkers, and therapeutic targets in metabolic diseases such as MASLD/MASH and obesity. This position offer the candidate an opportunity to work closely with a diverse and collaborative team of computational and experimental scientists, and clinicians on cutting-edge research at the intersection of AI and human health, and drive translational impact in metabolic diseases.
Key Responsibilities
Develop and implement AI/ML models to analyze and integrate multi-omics and clinical datasets related to metabolic disorders
Collaborate with biologists and clinicians to generate testable hypotheses from integrated datasets, and contribute actively to laboratory validations and screening studies through analytical findings
Design pipelines for preprocessing, normalization, and harmonization of heterogeneous data types
Apply and develop novel computational methodologies to uncover disease mechanisms
Drive biomarker discovery, patient stratification, target identification using machine learning approaches
Build a database integrating and linking multi-dimensional clinical and multi-omics data for metabolic diseases
Develop visualizations and dashboards to communicate complex data insights to interdisciplinary teams
Stay up to date with emerging computational techniques and tools in systems biology and AI
Drive high-impact scientific publications, patent filings, presentations and grant proposals
Qualifications
Ph.D. in Computational Biology, Bioinformatics, Computer Science, Data Science, Systems Biology, or a related field
Strong background in programming and AI/ML (e.g., deep learning, ensemble methods, graph-based learning, agentic AI, explainable AI)
Proficiency in programming languages such as Python and R; experience with AI/ML frameworks like TensorFlow, PyTorch, or scikit-learn
Demonstrated experience in integrating and analysing complex multi-omics datasets (e.g., RNA-seq, WGS, proteomics, GWAS)
Highly experienced with Unix/Linux environment and/or cloud architecture. Solid understanding of metabolic disease biology and relevant clinical phenotypes
Experience working with large-scale multi-dimensional datasets from biobanks, cohorts, or clinical trials
Track record of peer-reviewed publications in computational biology or bioinformatics
Experience in a cross-functional, collaborative environment in academia or industry
Knowledge in data security, data standards and interoperability, and reproducible research practices
Strong analytical and problem-solving skills, and attention to details
Excellent oral and written communication and presentation skills
Able to work independently and work collaboratively in a multi-disciplinary team environment
Competent project and data management, and organizational skills
Computational Scientist - Agentic AI & Data Integration (Metabolic Disease)
Position summary
We are seeking a highly motivated Computational Scientist with expertise in artificial intelligence, multi-omics data integration, and metabolic disease biology. The successful candidate will develop agentic AI frameworks and intelligent chatbots to automate data analysis and interpretation, integrate high-dimensional datasets (genomics, transcriptomics, proteomics, imaging, drug screening) with clinical data, and enhance scientific collaboration. This role offers a unique opportunity to work at the interface of AI, biomedical research, and clinical translation , collaborating with computational scientists, experimental biologists, and clinicians to uncover mechanisms, biomarkers, and therapeutic targets in metabolic diseases such as MASLD/MASH and obesity.
Key Responsibilities
Develop and implement AI/ML and agentic AI systems to analyze and integrate experimental/multi-omics and clinical datasets related to metabolic diseases.
Leverage agentic AI for automated hypothesis generation, exploratory data analysis, and prioritization of candidate mechanisms, biomarkers, and therapeutic targets.
Design and deploy conversational AI chatbots and knowledge assistants to enable intuitive access to complex datasets and analytical workflows.
Collaborate with biologists and clinicians to refine AI-driven hypotheses into testable biological studies and validations.
Build scalable data pipelines for preprocessing, harmonization, and integration of
heterogeneous omics and clinical data.
Apply and innovate computational methodologies to uncover disease mechanisms.
Drive therapeutic target identification, therapeutic strategies development, and patient stratification using machine learning and AI-driven inference.
Build databases and interactive dashboards integrating multi-dimensional omics and clinical data with AI insights.
Build a resource of public datasets and knowledgebase for metabolic diseases to be integrated with in-house proprietary data.
Stay up to date with emerging computational and agentic AI technologies relevant to systems biology, biomedical informatics, and translational medicine.
Collaborate with Industry partners and start-ups to accelerate agentic AI technologies development.
Contribute to high-impact scientific publications , grant proposals, and patent filings.
Qualifications and preferred experience
Ph.D. in Computational Biology, Bioinformatics, Computer Science, Data Science,
Systems Biology, or a related field.
Strong foundation in AI/ML, including deep learning, ensemble methods, graph-based learning, agentic AI, and explainable AI.
Proven experience in developing or integrating conversational AI/chatbots (e.g., LLM-based assistants, RAG systems, domain-specific AI agents).
Demonstrated experience in multi-omics data integration and analysis (e.g., RNA-seq, WGS, proteomics, GWAS, pheWAS, drug screens).
Proficiency in Python and R, with hands-on experience using TensorFlow, PyTorch, or scikit-learn.
Understanding of metabolic disease biology and relevant clinical phenotypes.
Experience working with large-scale, multi-dimensional datasets from biobanks, cohorts, or clinical trials.
Proficiency in Unix/Linux environments and cloud or HPC architecture .
Track record of peer-reviewed publications in computational biology, bioinformatics, or AI.
Strong analytical, communication, and organizational skills, with ability to work collaboratively in multidisciplinary teams.
Knowledge of data security, FAIR principles, and reproducible research practices.
Experience in a cross-functional, collaborative environment in academia or industry.
Strong analytical and problem-solving skills, and attention to details.
Excellent oral and written communication and presentation skills.
Able to work independently and work collaboratively in a multi-disciplinary team environment.
Competent project and data management, and organizational skills.
Interns (Minimum 6 months, full-time)
Job summary
We are seeking interns to develop computational methods, including big-data analytics, AI/ML approaches and visualization platforms, to analyze and integrate the multi-modal data (sequencing, imaging, spatial profiling, treatment response and clinical data) that can deliver translational outcomes to patients. The candidate will work with the PI and computational scientisits in the team to execute projects and carry out assigned tasks in a timely and efficient manner. He/She will report her progress on a regular basis. The intern is expected to work on any of these tasks, depending on field of study and interests.
Develop, implement and benchmark executable workflows for multi-omic datasets and image processing of histology images.
Organize and analyze in-house and publicly available datasets.
Develop visualization tools to visualize results in a meaningful way.
Curation of therapies and biomarkers, and patient clinical data.
Requirements
Relevant fields of studies: Computational Biology, Bioinformatics, Computer Science, Biology, Mathematics, Pharmacy, Pharmaceutical Sciences, Medicine, Engineering
The candidate should have basic programming skills (e.g. Python, R, RStudio, Jupyter Notebook, RShiny, SQL)
Familiarity with Unix/Linux environment or cloud architecture would be an advantage
Strong analytical and problem-solving skills
Excellent oral and written communication and presentation skills
Able to work independently, and as part of a team
PhD students
We are actively seeking PhD students to join us in the development of novel AI/ML approaches and knowledge graphs to integrate multimodal and multiscale biomedical and research data to uncover new biological mechanisms and panel of features to predict the right precision medicine strategies.
To apply, please email your cover letter, CV and names of references to woo_xing_yi@a-star.edu.sg