We are actively recruiting highly motivated post-doctoral fellows, bioinformaticians, students, interns to join our group.
Computational Scientist - Multimodal AI & Data Integration (Metabolic Disease)
Position summary
We are seeking a highly motivated Computational Scientist with expertise in artificial intelligence, multi-omics data integration, and metabolic disease biology . The successful candidate will play a critical role in developing AI/ML frameworks to integrate and analyze high-dimensional biological datasets (e.g. genomics, transcriptomics, proteomics, imaging) with clinical data to identify novel mechanisms, biomarkers, and therapeutic targets in metabolic diseases such as MASLD/MASH and obesity. This position offer the candidate an opportunity to work closely with a diverse and collaborative team of computational and experimental scientists, and clinicians on cutting-edge research at the intersection of AI and human health, and drive translational impact in metabolic diseases.
Key Responsibilities
Develop and implement AI/ML models to analyze and integrate multi-omics and clinical datasets related to metabolic disorders
Collaborate with biologists and clinicians to generate testable hypotheses from integrated datasets, and contribute actively to laboratory validations and screening studies through analytical findings
Design pipelines for preprocessing, normalization, and harmonization of heterogeneous data types
Apply and develop novel computational methodologies to uncover disease mechanisms
Drive biomarker discovery, patient stratification, target identification using machine learning approaches
Build a database integrating and linking multi-dimensional clinical and multi-omics data for metabolic diseases
Develop visualizations and dashboards to communicate complex data insights to interdisciplinary teams
Stay up to date with emerging computational techniques and tools in systems biology and AI
Drive high-impact scientific publications, patent filings, presentations and grant proposals
Qualifications
Ph.D. in Computational Biology, Bioinformatics, Computer Science, Data Science, Systems Biology, or a related field
Strong background in programming and AI/ML (e.g., deep learning, ensemble methods, graph-based learning, agentic AI, explainable AI)
Proficiency in programming languages such as Python and R; experience with AI/ML frameworks like TensorFlow, PyTorch, or scikit-learn
Demonstrated experience in integrating and analysing complex multi-omics datasets (e.g., RNA-seq, WGS, proteomics, GWAS)
Highly experienced with Unix/Linux environment and/or cloud architecture. Solid understanding of metabolic disease biology and relevant clinical phenotypes
Experience working with large-scale multi-dimensional datasets from biobanks, cohorts, or clinical trials
Track record of peer-reviewed publications in computational biology or bioinformatics
Experience in a cross-functional, collaborative environment in academia or industry
Knowledge in data security, data standards and interoperability, and reproducible research practices
Strong analytical and problem-solving skills, and attention to details
Excellent oral and written communication and presentation skills
Able to work independently and work collaboratively in a multi-disciplinary team environment
Competent project and data management, and organizational skills
Interns (Minimum 6 months, full-time)
Job summary
We are seeking interns to develop computational methods, including big-data analytics, AI/ML approaches and visualization platforms, to analyze and integrate the multi-modal data (sequencing, imaging, spatial profiling, treatment response and clinical data) that can deliver translational outcomes to patients. The candidate will work with the PI and computational scientisits in the team to execute projects and carry out assigned tasks in a timely and efficient manner. He/She will report her progress on a regular basis. The intern is expected to work on any of these tasks, depending on field of study and interests.
Develop, implement and benchmark executable workflows for multi-omic datasets and image processing of histology images.
Organize and analyze in-house and publicly available datasets.
Develop visualization tools to visualize results in a meaningful way.
Curation of therapies and biomarkers, and patient clinical data.
Requirements
Relevant fields of studies: Computational Biology, Bioinformatics, Computer Science, Biology, Mathematics, Pharmacy, Pharmaceutical Sciences, Medicine, Engineering
The candidate should have basic programming skills (e.g. Python, R, RStudio, Jupyter Notebook, RShiny, SQL)
Familiarity with Unix/Linux environment or cloud architecture would be an advantage
Strong analytical and problem-solving skills
Excellent oral and written communication and presentation skills
Able to work independently, and as part of a team
PhD students
We are actively seeking PhD students to join us in the development of novel AI/ML approaches and knowledge graphs to integrate multimodal and multiscale biomedical and research data to uncover new biological mechanisms and panel of features to predict the right precision medicine strategies.
To apply, please email your cover letter, CV and names of references to woo_xing_yi@a-star.edu.sg