W Lee lab@SNU (est. 2014)
The goals of our research are i) to better understand the genetic and molecular bases for variable drug response and drug interactions with a focus on membrane transporters; ii) to develop novel proteasome inhibitor drugs and their delivery strategies to achieve desirable pharmacokinetic (PK) and pharmacodynamic (PD) profiles; and iii) to predict and evaluate the PK and PD profiles of drug candidates in pre-clinical and early clinical trial settings and to assess the drug exposure, target binding, and response using physiologically-based PK modeling.