H. J. Choi, T. W. Lo, K. J. Cutler, D. Huang, W. R. Will, and Paul A. Wiggins, “Protein overabundance is driven by growth robustness,” bioRxiv, Aug 2024.
T. W. Lo, H. J. Choi, D. Huang, and Paul A. Wiggins, “Noise robustness and metabolic load determine the principles of central dogma regulation,” Sci Adv, vol. 10, no. 34, p. eado3095, Aug 2024.
D. Huang, T. W. Lo, H. Merrikh, and Paul A. Wiggins, “Quantitative in vivo measurement of fork velocity in bacterial cells by deep sequencing,” Nature Communications, vol. 14, p. 1762, 2023.
K. J. Cutler, C. Stringer, T. W. Lo, L. Rappez, N. Stroustrup, S. Brook Peterson, Paul A. Wiggins, and J. D. Mougous, “Omnipose: a high-precision morphology-independent solution for bacterial cell segmentation.” Nat Methods, vol. 19, no. 11, pp. 1438–1448, Nov 2022.
L. A. Gallagher, E. Velazquez, S. B. Peterson, J. C. Charity, M. C. Radey, M. J. Gebhardt, F. Hsu, L. M. Shull, K. J. Cutler, K. Macareno, M. H. de Moraes, K. M. Penewit, J. Kim, P. A. Andrade, T. LaFramboise, S. J. Salipante, M. L. Reniere, V. de Lorenzo, Paul A. Wiggins, S. L. Dove, and J. D. Mougous, “Genome- wide protein-DNA interaction site mapping in bacteria using a double-stranded DNA-specific cytosine deaminase,” Nat Microbiol, vol. 7, no. 6, pp. 844–855, Jun 2022.
D. Huang, T. W. Lo, H. Merrikh, and Paul A. Wiggins, “Characterizing stochastic cell-cycle dynamics in exponential growth,” Phys Rev E, vol. 105, no. 1-1, p. 014420, Jan 2022.
Z. Kazi, I. M. Shelby, H. Watanabe, K. M. Itoh, V. Shutthanandan, Paul A. Wiggins, and K.-M. C. Fu, “Wide-Field Dynamic Magnetic Microscopy Using Double-Double Quantum Driving of a Diamond Defect Ensemble.” Phys. Rev. Applied, vol. 15, p. 054032, May 2021.
M. H. de Moraes, F. Hsu, D. Huang, D. E. Bosch, J. Zeng, M. C. Radey, N. Simon, H. E. Ledvina, J. P. Frick, Paul A. Wiggins, S. B. Peterson, and J. D. Mougous, “An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations,” Elife, vol. 10, Jan 2021.
C. H. LaMont and Paul A. Wiggins, “Correspondence between thermodynamics and inference,” Phys Rev E, vol. 99, no. 5-1, p. 052140, May 2019.
S.-Y. Ting, D. E. Bosch, S. M. Mangiameli, M. C. Radey, S. Huang, Y.-J. Park, K. A. Kelly, S. K. Filip, Y. A. Goo, J. K. Eng, M. Allaire, D. Veesler, Paul A. Wiggins, S. B. Peterson, and J. D. Mougous, “Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins,” Cell, vol. 175, no. 5, pp. 1380–1392.e14, Nov 2018.
S. M. Mangiameli, J. A. Cass, H. Merrikh, and Paul A. Wiggins, “The bacterial replisome has factory- like localization,” Curr Genet, vol. 64, no. 5, pp. 1029–1036, Oct 2018.
J. Corbitt, J. S. Yeo, C. I. Davis, M. LeRoux, and Paul A. Wiggins, “Type VI Secretion System Dynamics Reveals a Novel Secretion Mechanism in Pseudomonas aeruginosa,” J Bacteriol, vol. 200, no. 11, Jun 2018.
S. Stylianidou, T. J. Lampo, A. J. Spakowitz, and Paul A. Wiggins, “Strong disorder leads to scale invariance in complex biological systems,” Phys Rev E, vol. 97, no. 6-1, p. 062410, Jun 2018.
J. R. Russell, M. T. Cabeen, Paul A. Wiggins, J. Paulsson, and R. Losick, “Noise in a phosphorelay drives stochastic entry into sporulation in Bacillus subtilis,” EMBO J, vol. 36, no. 19, pp. 2856–2869, 10 2017.
S. M. Mangiameli, B. T. Veit, H. Merrikh, and Paul A. Wiggins, “The Replisomes Remain Spatially Proximal throughout the Cell Cycle in Bacteria,” PLoS Genet, vol. 13, no. 1, p. e1006582, Jan 2017.
S. M. Mangiameli, C. N. Merrikh, Paul A. Wiggins, and H. Merrikh, “Transcription leads to pervasive replisome instability in bacteria,” Elife, vol. 6, Jan 2017.
T. J. Lampo, S. Stylianidou, M. P. Backlund, Paul A. Wiggins, and A. J. Spakowitz, “Cytoplasmic RNA- Protein Particles Exhibit Non-Gaussian Subdiffusive Behavior,” Biophys J, vol. 112, no. 3, pp. 532–542, Feb 2017.
J. A. Cass, S. Stylianidou, N.J.Kuwada, B.Traxler, and Paul A. Wiggins,“Probing bacterial cell biology using image cytometry,” Mol Microbiol, vol. 103, no. 5, pp. 818–828, Mar 2017.
S. Stylianidou, C. Brennan, S. B. Nissen, N. J. Kuwada, and Paul A. Wiggins, “SuperSegger: robust image segmentation, analysis and lineage tracking of bacterial cells,” Mol Microbiol, vol. 102, no. 4, pp. 690–700, Nov 2016.
J. A. Cass, N. J. Kuwada, B. Traxler, and Paul A. Wiggins, “Escherichia coli Chromosomal Loci Segregate from Midcell with Universal Dynamics,” Biophys J, vol. 110, no. 12, pp. 2597–609, Jun 2016.
C. H. LaMont and Paul A. Wiggins, “The development of an information criterion for change-point analysis,” Neural Comput, vol. 28, no. 3, pp. 594–612, Mar 2016.
P. A. Wiggins, “An Information-Based Approach to Change-Point Analysis with Applications to Bio- physics and Cell Biology,” Biophys J, vol. 109, no. 2, pp. 346–54, Jul 2015.
T. J. Lampo, N. J. Kuwada, Paul A. Wiggins, and A. J. Spakowitz, “Physical modeling of chromosome segregation in Escherichia coli reveals impact of force and DNA relaxation,” Biophys J, vol. 108, no. 1, pp. 146–53, Jan 2015.
M. LeRoux, R. L. Kirkpatrick, E. I. Montauti, B. Q. Tran, S. B. Peterson, B. N. Harding, J. C. Whitney, A. B. Russell, B. Traxler, Y. A. Goo, D. R. Goodlett, Paul A. Wiggins, and J. D. Mougous, “Kin cell lysis is a danger signal that activates antibacterial pathways of Pseudomonas aeruginosa.” Elife, vol. 4, 2015.
N. J. Kuwada, B. Traxler, and Paul A. Wiggins, “High-throughput cell-cycle imaging opens new doors for discovery,” Curr Genet, no. 1-4, May 2015.
N. J. Kuwada, B. Traxler, and Paul A. Wiggins, “Genome-scale quantitative characterization of bacterial protein localization dynamics through- out the cell cycle,” Mol Microbiol, vol. 95, no. 1, pp. 64–79, Jan 2015.
E. V. Dolgosheina, S. C. Y. Jeng, S. S. S. Panchapakesan, R. Cojocaru, P. S. K. Chen, P. D. Wilson, N. Hawkins, Paul A. Wiggins, and P. J. Unrau, “RNA mango aptamer-fluorophore: a bright, high- affinity complex for RNA labeling and tracking,” ACS Chem Biol, vol. 9, no. 10, pp. 2412–20, Oct 2014.
C. Garmendia-Torres, A. Skupin, S. A. Michael, P. Ruusuvuori, N. J. Kuwada, D. Falconnet, G. A. Cary, C. Hansen, Paul A. Wiggins, and A. M. Dudley, “Unidirectional P-body transport during the yeast cell cycle,” PLoS One, vol. 9, no. 6, p. e99428, 2014.
S. Stylianidou, N. J. Kuwada, and Paul A. Wiggins, “Cytoplasmic dynamics reveals two modes of nucleoid-dependent mobility,” Biophys J, vol. 107, no. 11, pp. 2684–92, Dec 2014.
A. Javer, N. J. Kuwada, Z. Long, V. G. Benza, K. D. Dorfman, Paul A. Wiggins, P. Cicuta, and M. C. Lagomarsino, “Persistent super-diffusive motion of Escherichia coli chromosomal loci,” Nat Commun, vol. 5, p. 3854, 2014.
M.Venkatareddy,S.Wang,Y.Yang,S.Patel,L.Wickman,R.Nishizono,M.Chowdhury,J.Hodgin,Paul A. Wiggins, and R. C. Wiggins, “Estimating podocyte number and density using a single histologic section,” J Am Soc Nephrol, vol. 25, no. 5, pp. 1118–29, May 2014.
B. C. Ross and Paul A. Wiggins, “Calculator for conformational statistics of DNA and applications to high-curvature bending.” Physical Review E, vol. 87, p. 032707, 2013.
B. R. Kulasekara, C. Kamischke, H. D. Kulasekara, M. Christen, Paul A. Wiggins, and S. I. Miller, “c- di-GMP heterogeneity is generated by the chemotaxis machinery to regulate flagellar motility,” Elife, vol. 2, p. e01402, 2013.
N. J. Kuwada, K. C. Cheveralls, B. Traxler, and Paul A. Wiggins, “Mapping the driving forces of chromosome structure and segregation in Escherichia coli,” Nucleic Acids Res, vol. 41, no. 15, pp. 7370–7, Aug 2013.
A. B. Russell, M. LeRoux, K. Hathazi, D. M. Agnello, T. Ishikawa, Paul A. Wiggins, S. N. Wai, and J. D. Mougous, “Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors,” Nature, vol. 496, no. 7446, pp. 508–12, Apr 2013.
B. C. Ross and Paul A. Wiggins, “Measuring chromosome conformation with degenerate labels,” Phys Rev E Stat Nonlin Soft Matter Phys, vol. 86, no. 1 Pt 1, p. 011918, Jul 2012.
J. R. O’Connor, N. J. Kuwada, V. Huangyutitham, Paul A. Wiggins, and C. S. Harwood, “Surface sens- ing and lateral subcellular localization of WspA, the receptor in a chemosensory-like system leading to c-di-GMP production,” Mol Microbiol, vol. 86, no. 3, pp. 720–9, Nov 2012.
R. T. Dame, O. Espeli, D.C.Grainger, and Paul A. Wiggins,“Multidisciplinary perspectives on bacterial genome organization and dynamics,” Mol Microbiol, vol. 86, no. 5, pp. 1023–30, Dec 2012.
D. Van Valen, D. Wu, Y.-J. Chen, H. Tuson, Paul A. Wiggins, and R. Phillips, “A single-molecule Hershey-Chase experiment,” Curr Biol, vol. 22, no. 14, pp. 1339–43, Jul 2012.
M. Fritsche, S. Li, D. W. Heermann, and Paul A. Wiggins, “A model for Escherichia coli chromosome packaging supports transcription factor-induced DNA domain formation,” Nucleic Acids Res, vol. 40, no. 3, pp. 972–80, Feb 2012.
M. LeRoux, J. A. De Leon, N. J. Kuwada, A. B. Russell, D. Pinto-Santini, R. D. Hood, D. M. Agnello, S. M. Robertson, Paul A. Wiggins, and J. D. Mougous, “Quantitative single-cell characterization of bacterial interactions reveals type VI secretion is a double-edged sword,” Proc Natl Acad Sci U S A, vol. 109, no. 48, pp. 19 804–9, Nov 2012.
C. L. Chaffer, I. Brueckmann, C. Scheel, A. J. Kaestli, Paul A. Wiggins, L. O. Rodrigues, M. Brooks, F. Reinhardt, Y. Su, K. Polyak, L. M. Arendt, C. Kuperwasser, B. Bierie, and R. A. Weinberg, “Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state,” Proc Natl Acad Sci U S A, vol. 108, no. 19, pp. 7950–5, May 2011.
Paul A. Wiggins, K. C. Cheveralls, J. S. Martin, R. Lintner, and J. Kondev, “Strong intranucleoidinterac- tions organize the Escherichia coli chromosome into a nucleoid filament,” Proc Natl Acad Sci U S A, vol. 107, no. 11, pp. 4991–5, Mar 2010.
R. Phillips, T. Ursell, Paul A. Wiggins, and P. Sens, “Emerging roles for lipids in shaping membrane- protein function,” Nature, vol. 459, no. 7245, pp. 379–85, May 2009.
Paul A. Wiggins, R. T. Dame, M. C. Noom, and G. J. L. Wuite, “Protein-mediated molecular bridging: a key mechanism in biopolymer organization,” Biophys J, vol. 97, no. 7, pp. 1997–2003, Oct 2009.
H. J. Lee, E. L. Peterson, R. Phillips, W. S. Klug, and Paul A. Wiggins, “Membrane shape as a reporter for applied forces,” Proceedings of the National Academy of Sciences, vol. 105, no. 49, pp. 19 253–19 257, 2008.
H. G. Garcia, P. Grayson, L. Han, M. Inamdar, J. Kondev, P. C. Nelson, R. Phillips, J. Widom, and Paul A. Wiggins, “Biological consequences of tightly bent DNA: the other life of a macromolecular celebrity,” Biopolymers, vol. 85, no. 2, pp. 115–130, 2007.
Paul A. Wiggins and P. C. Nelson, “Generalized theory of semiflexible polymers,” Physical Review E, vol. 73, no. 3, p. 031906, 2006.
Paul A. Wiggins, T. Van Der Heijden, F. Moreno-Herrero, A. Spakowitz, R. Phillips, J. Widom, C. Dekker, and P. C. Nelson, “High flexibility of DNA on short length scales probed by atomic force microscopy,” Nature nanotechnology, vol. 1, no. 2, pp. 137–141, 2006.
Paul A. Wiggins, R. Phillips, and P. C. Nelson, “Exact theory of kinkable elastic polymers,” Physical Review E, vol. 71, no. 2, p. 021909, 2005.
Paul A. Wiggins and R. Phillips, “Membrane-protein interactions in mechanosensitive channels,” Bio- physical journal, vol. 88, no. 2, pp. 880–902, 2005.
Paul A. Wiggins and R. Phillips, “Analytic models for mechanotransduction: gating a mechanosensitive channel,” Proceedings of the National Academy of Sciences, vol. 101, no. 12, pp. 4071–4076, 2004.
Paul A. Wiggins and D. Lai, “Neutron Star-Black Hole Tidal Interaction,” The Astrophysical Journal, vol. 532, pp. 530–539, 2000.
R. Q. Erkamp, Paul A. Wiggins, A. R. Skovoroda, S. Y. Emelianov, and M. O’Donnell, “Measuring the elastic modulus of small tissue samples,” Ultrason Imaging, vol. 20, no. 1, pp. 17–28, Jan 1998.