Research

Kelly Vogt, MD, FRCSC

Research Coordinator, Assistant Professor of Surgery & Clinician Scientist, Associate Medical Director - Trauma Program

The Division of General Surgery at Western University is extremely proud of our Resident Research Program. Residents are expected to complete novel research 4 of their 5 years in training. In the first year, residents and their research supervisor work together to create a publication-ready manuscript. In their second year, residents choose a research stream for the remainder of their residency (resident research streams shown below). Resident research at Western is supported by a Resident Research Director, Epidemiologists, and Research Assistants. Our residents have a tremendous track record of success with both presentation at National and International meetings, as well as publications (publication list shown below). For any questions about resident research at Western, please email our Resident Research Director, Dr. Kelly Vogt (Kelly.Vogt@lhsc.on.ca).




Highlights of the General Surgery Research Program at Western University:

  • Dedicated Research Coordinator

  • Yearly Research Retreat

  • General Surgery Research Day

  • Funding to Present

  • Excellent Production

-The resident presentations at CAGS

- Podiums at ACS

- Multiple publications

- Multiple Awards

Resident Research Streams:

General Surgery Resident Publications List:

Publications during Residency

General Surgery Residents

October 2020

Hartford L, Doucet V, Ramkumar J, Leslie K, Shum J, Asai K. The impact of a new hepatopancreatobiliary surgery program on the management of pancreatic cancer at Health Sciences North. Can J Surg. 2019 Aug 1;62(4):275-280. doi: 10.1503/cjs.016517. PMID: 31348629; PMCID: PMC6660278.

Maciver AH, Hartford LB. ASO Author Reflections: Multimodal Strategy Controls Pain and Reduces Opioid Prescription in Outpatient Breast Surgery. Ann Surg Oncol. 2019 Dec;26(Suppl 3):824-825. doi: 10.1245/s10434-019-07960-1. Epub 2019 Oct 30. PMID: 31667720.

Hartford LB, Van Koughnett JAM, Murphy PB, Knowles SA, Wigen RB, Allen LJ, Clarke CFM, Brackstone M, Gray DK, Maciver AH. The Standardization of Outpatient Procedure (STOP) Narcotics: A Prospective Health Systems Intervention to Reduce Opioid Use in Ambulatory Breast Surgery. Ann Surg Oncol. 2019

Oct;26(10):3295-3304. doi: 10.1245/s10434-019-07539-w. Epub 2019 Jul 24. PMID: 31342371.

Hartford LB, Van Koughnett JAM, Murphy PB, Vogt KN, Hilsden RJ, Clarke CF, Allen LJ, Gray SD, Parry NG, Gray DK, Leslie KA. Standardization of Outpatient Procedure (STOP) Narcotics: A Prospective Non-Inferiority Study to Reduce Opioid Use in Outpatient General Surgical Procedures. J Am Coll Surg. 2019

Jan;228(1):81-88.e1. doi: 10.1016/j.jamcollsurg.2018.09.008. Epub 2018 Oct 22. PMID: 30359828.

Kuper, T.M., Federman, N., Sharieff, S., Tejpar, S., LeBlanc, D., Murphy, P.B., Parry, N., Leeper, R. Chest Tube Insertion Among Surgical and Nonsurgical Trainees: How Skilled Are Our Residents? (2020) Journal of Surgical Research, 247, pp. 344-349.

Kuper, T.M., Murphy, P.B., Kaur, B., Ott, M.C. Prophylactic Negative Pressure Wound Therapy for Closed Laparotomy Incisions: A Meta-analysis of Randomized Controlled Trials (2020) Annals of Surgery, 271 (1), pp. 67-74. Cited 3 times

Hilsden R, Leeper R, Koichopolos J, Vandelinde JD, Parry N, Thompson D, Myslik F. Point-of-care biliary ultrasound in the emergency department (BUSED): implications for surgical referral and emergency department wait times. Trauma Surg Acute Care Open. 2018 Jul 30;3(1):e000164. doi: 10.1136/tsaco-2018-000164. PMID: 30109274; PMCID: PMC6078236.

Koichopolos J, Hawel J, Shlomovitz E, Habaz I, Elnahas A, Alkhamesi NA, Schlachta CM. Correlation of surgical trainee performance on laparoscopic versus endoscopic simulation. Surg Endosc. 2020 May;34(5):2007-2011. doi: 10.1007/s00464-019-06978-6. Epub 2019 Jul 18. PMID: 31321533.

Koichopolos J, Keow J, Parfitt J, Yoshy C, Wiseman D, Leslie K. Complete duodenal necrosis associated with non-traumatic duodenal hematoma requiring emergent pancreatico duodenectomy. Int J Surg Case Rep. 2020;66:53-57. doi: 10.1016/j.ijscr.2019.11.026. Epub 2019 Nov 19. PMID: 31812122; PMCID: PMC6906656.

Koichopolos J, Hamidi M, Cecchini M, Leslie K. Gastric outlet obstruction by a lost gallstone: Case report and literature review. Int J Surg Case Rep. 2017;41:128-131. doi: 10.1016/j.ijscr.2017.10.014. Epub 2017 Oct 17. PMID: 29073549; PMCID: PMC5655411.

Murphy PB, Paskar D, Hilsden R, Koichopolos J, Mele TS; Western Ontario Research Collaborative on Acute Care Surgery. Acute care surgery: a means for providing cost-effective, quality care for gallstone pancreatitis. World J Emerg Surg. 2017 Apr 28;12:20. doi: 10.1186/s13017-017-0128-3. PMID: 28465716; PMCID: PMC5410020.

Koichopolos J, Hilsden R, Myslik F, Thompson D, Vandelinde J, Leeper R. Surgeon attitudes toward point of care ultrasound for biliary disease: a nationwide Canadian survey. Can J Surg. 2020 Jan 9;63(1):E9-E12. doi: 10.1503.cjs/010218. PMID: 31916431

Chapeskie, H., Juliao, A., Payne, S., Koichopolos, J. Evaluation of the safety of epinephrine in digital nerve blockade: Retrospective case series analysis of 1334 toe surgeries (2016) Canadian Family Physician, 62 (6), pp. e334-e339.

Ghasemi, F., Tessier, T.M., Gameiro, S.F., Maciver, A.H., Cecchini, M.J., Mymryk, J.S. High MHC-II expression in Epstein–Barr virus-associated gastric cancers suggests that tumor cells serve an important role in antigen presentation (2020) Scientific Reports, 10 (1), art. no. 14786, .

Pinto, N., Prokopec, S.D., Ghasemi, F., Meens, J., Ruicci, K.M., Khan, I.M., Mundi, N., Patel, K., Han, M.W., Yoo, J., Fung, K., MacNeil, D., Mymryk, J.S., Datti, A., Barrett, J.W., Boutros, P.C., Ailles, L., Nichols, A.C. Flavopiridol causes cell cycle inhibition and demonstrates anti-cancer activity in anaplastic thyroid cancer models (2020) PLoS ONE, 15 (9 September), art. no. e0239315, .

Mundi, N., Ghasemi, F., Zeng, P.Y.F., Prokopec, S.D., Patel, K., Kim, H.A.J., Di Gravio, E., MacNeil, D., Khan, M.I., Han, M.W., Shaikh, M., Mendez, A., Yoo, J., Fung, K., Gameiro, S.F., Palma, D.A., Mymryk, J.S., Barrett, J.W., Boutros, P.C., Nichols, A.C. Sex disparities in head & neck cancer driver genes: An analysis of the TCGA dataset (2020) Oral Oncology, 104, art. no. 104614, .

Black, M., Ghasemi, F., Sun, R.X., Stecho, W., Datti, A., Meens, J., Pinto, N., Ruicci, K.M., Khan, M.I., Han, M.W., Shaikh, M., Yoo, J., Fung, K., MacNeil, D., Palma, D.A., Winquist, E., Howlett, C.J., Mymryk, J.S., Ailles, L., Boutros, P.C., Barrett, J.W., Nichols, A.C. Spleen tyrosine kinase expression is correlated with human papillomavirus in head and neck cancer (2020) Oral Oncology, 101, art. no. 104529, . Cited 1 time.

Gameiro, S.F., Ghasemi, F., Barrett, J.W., Koropatnick, J., Nichols, A.C., Mymryk, J.S., Maleki Vareki, S.

DIY: Visualizing the immune landscape of tumors using transcriptome and methylome data (2020) Methods in Enzymology, 636, pp. 49-76.

Prusinkiewicz, M.A., Gameiro, S.F., Ghasemi, F., Dodge, M.J., Zeng, P.Y.F., Maekebay, H., Barrett, J.W., Nichols, A.C., Mymryk, J.S. Survival-associated metabolic genes in human papillomavirus-positive head and neck cancers (2020) Cancers, 12 (1), art. no. 253, . Cited 4 times.

Gameiro, S.F., Ghasemi, F., Barrett, J.W., Nichols, A.C., Mymryk, J.S. High level expression of MHC-II in HPV+ head and neck cancers suggests that tumor epithelial cells serve an important role as accessory antigen presenting cells (2019) Cancers, 11 (8), art. no. 1129, . Cited 2 times.

Ghasemi, F., Prokopec, S.D., MacNeil, D., Mundi, N., Gameiro, S.F., Howlett, C., Stecho, W., Plantinga, P., Pinto, N., Ruicci, K.M., Khan, M.I., Yoo, J., Fung, K., Sahovaler, A., Palma, D.A., Winquist, E., Mymryk, J.S., Barrett, J.W., Boutros, P.C., Nichols, A.C. Mutational analysis of head and neck squamous cell carcinoma stratified by smoking status (2019) JCI Insight, 4 (1), art. no. e123443, . Cited 4 times.

Gameiro, S.F., Ghasemi, F., Barrett, J.W., Koropatnick, J., Nichols, A.C., Mymryk, J.S., Maleki Vareki, S.

Treatment-naïve HPV+ head and neck cancers display a T-cell-inflamed phenotype distinct from their HPV- counterparts that has implications for immunotherapy

(2018) OncoImmunology, 7 (10), art. no. e1498439, . Cited 24 times.

Hartford LB, Van Koughnett JAM, Murphy PB, Knowles SA, Wigen RB, Allen LJ, Clarke CFM, Brackstone M, Gray DK, Maciver AH. The Standardization of Outpatient Procedure (STOP) Narcotics: A Prospective Health Systems Intervention to Reduce Opioid Use in Ambulatory Breast Surgery. Ann Surg Oncol. 2019

Oct;26(10):3295-3304. doi: 10.1245/s10434-019-07539-w. Epub 2019 Jul 24. PMID: 31342371.

Wigen RB, Duan W, Moraes TJ, Chiu PPL. Predictors of Long-Term Pulmonary Morbidity in Children with Congenital Diaphragmatic Hernia. Eur J Pediatr Surg. 2019 Feb;29(1):120-124. doi: 10.1055/s-0038-1676586. Epub 2018 Dec 24. PMID: 30583297.

Ball LJ, Sherazi A, Laczko D, Gupta K, Koivu S, Weir MA, Mele T, Tirona R, McCormick JK, Silverman M. Validation of an Algorithm to Identify Infective Endocarditis in People Who Inject Drugs. Med Care. 2018 Oct;56(10):e70-e75. doi:

Whiston C, Ali S, Wright B, Wonnacott D, Stang AS, Thompson GC, Bhat C, Todorovich S, Mishra A, Laczko D, Miller M, Poonai N. Is caregiver refusal of analgesics a barrier to pediatric emergency pain management? A cross-sectional study in two Canadian centres. CJEM. 2018 Nov;20(6):892-902.

Aldossary MY, Alayed AA, Amr SS, Alqahtani S, Alnahawi M, Alqahtani MS. Gallbladder cancer in Eastern Province of Saudi Arabia: A retrospective cohort study. Ann Med Surg (Lond). 2018 Sep 26;35:117-123.

Mori Y, Ko E, Furrer R, Qu LC, Wiber SC, Fantus IG, Thevis M, Medline A, Giacca A.Endocr Connect. 2018 May;7(5):739-748. doi: 10.1530/EC-17-0358. Epub 2018 Apr 24.

Breast reconstruction in the presence of postmastectomy radiation at hospitals associated with Western University. Liu R, Latosinsky S. 2020. The Breast Journal. In press

Pang G, Look Hong NJ, Paull G, Dobransky J, Kupper S, Hurton S, Kagedan DJ, Quan ML, Helyer L, Nessim C, Wright FC. Squamous Cell Carcinoma with Regional Metastasis to Axilla or Groin Lymph Nodes: a Multicenter Outcome Analysis. Ann Surg Oncol. 2019 Dec;26(13):4642-4650. doi: 10.1245/s10434-019-07743-8. Epub 2019 Aug 22. PMID: 31440926.

Chesney TR, Pang G, Ahmed N. Caring for Older Surgical Patients: Contemporary Attitudes, Knowledge, Practices, and Needs of General Surgeons and Residents. Ann Surg. 2018 Jul;268(1):77-85. doi: 10.1097/SLA.0000000000002363. PMID: 28654541.

Way C, Wayne C, Grandpierre V, Harrison BJ, Travis N, Nasr A. Thoracoscopy vs. thoracotomy for the repair of esophageal atresia and tracheoesophageal fistula: a systematic review and meta-analysis. Pediatr Surg Int. 2019 Nov;35(11):1167-1184. doi: 10.1007/s00383-019-04527-9. Epub 2019 Jul 29. PMID: 31359222.

Kerollos Nashat Wanis , Arin L Madenci, Miguel A Hernán, Eleanor J Murray . Adjusting for adherence in randomized trials when adherence is measured as a continuous variable: An application to the Lipid Research Clinics Coronary Primary Prevention Trial (2020) Clinical Trials, 17 (5), pp. 570-575.

Sarvet, A.L., Wanis, K.N., Stensrud, M.J., Hernán, M.A. A Graphical Description of Partial Exchangeability

(2020) Epidemiology, pp. 365-368.

Wanis, K.N., Linecker, M., Madenci, A.L., Müller, P.C., Nüssler, N., Brusadin, R., Robles-Campos, R., Hahn, O., Serenari, M., Jovine, E., Lehwald, N., Knoefel, W.T., Reese, T., Oldhafer, K., de Santibañes, M., Ardiles, V., Lurje, G., Capelli, R., Enne, M., Ratti, F., Aldrighetti, L., Zhurbin, A.S., Voskanyan, S., Machado, M., Kitano, Y., Adam, R., Chardarov, N., Skipenko, O., Ferri, V., Vicente, E., Tomiyama, K., Hernandez-Alejandro, R.Variation in complications and mortality following ALPPS at early-adopting centers

(2020) HPB,

Wanis, K.N., Maleyeff, L., Van Koughnett, J.A.M., H D Colquhoun, P., Ott, M., Leslie, K., Hernandez-Alejandro, R., Kim, J.J. Health and Economic Impact of Intensive Surveillance for Distant Recurrence After Curative Treatment of Colon Cancer: A Mathematical Modeling Study (2019) Diseases of the colon and rectum, 62 (7), pp. 872-881.

Wanis, K.N., Madenci, A.L., Dokus, M.K., Tomiyama, K., Al-Judaibi, B.M., Hernán, M.A., Hernandez-Alejandro, R. The Effect of the Opioid Epidemic on Donation after Circulatory Death Transplantation Outcomes (2019) Transplantation, 103 (5), pp. 973-979.

Wanis, K.N., Madenci, A.L., Dokus, M.K., Orloff, M.S., Levstik, M.A., Hernandez-Alejandro, R., Hernán, M.A. The meaning of confounding adjustment in the presence of multiple versions of treatment: an application to organ transplantation (2019) European Journal of Epidemiology, 34 (3), pp. 225-233.

Smith, S., White, J., Wanis, K.N., Beckett, A., McAlister, V.C., Hilsden, R. The effectiveness of junctional tourniquets: A systematic review and meta-analysis (2019) Journal of Trauma and Acute Care Surgery, 86 (3), pp. 532-539.

Szmulewicz, A., Wanis, K.N., Gripper, A., Angriman, F., Hawel, J., Elnahas, A., Alkhamesi, N.A., Schlachta, C.M. Mental health quality of life after bariatric surgery: A systematic review and meta-analysis of randomized clinical trials (2019) Clinical obesity, 9 (1), p. e12290.

Enrique, M.T.-A., Wanis, K.N., Garcia-Ochoa, C., Sela, N., Sharma, H., Al Hasan, I., Quan, D., Al-Judaibi, B., Levstik, M., Hernandez-Alejandro, R. Can we reduce ischemic cholangiopathy rates in donation after cardiac death liver transplantation after 10 years of practice? Canadian single-centre experience

(2019) Canadian Journal of Surgery, 62 (1), pp. 44-51.

Wanis, K.N., Ott, M., Van Koughnett, J.A.M., Colquhoun, P., Brackstone, M. Long-term oncological outcomes following emergency resection of colon cancer (2018) International Journal of Colorectal Disease, 33 (11), pp. 1525-1532.

Zener, R., Istl, A.C., Wanis, K.N., Hocking, D., Kachura, J., Alshehri, S., Mujoomdar, A., Latosinsky, S., Wiseman, D. Thirty-day complication rate of percutaneous gastrojejunostomy and gastrostomy tube insertion using a single-puncture, dual-anchor technique (2018) Clinical Imaging, 50, pp. 104-108.

Madenci, A.L., Wanis, K.N., Kurth, T. Anesthesia care handovers and risk of adverse outcomes

(2018) JAMA - Journal of the American Medical Association, 319 (21), p. 2236.

Wanis, K.N., Ardiles, V., Alvarez, F.A., Tun-Abraham, M.E., Linehan, D., de Santibañes, E., Hernandez-Alejandro, R. Intermediate-term survival and quality of life outcomes in patients with advanced colorectal liver metastases undergoing associating liver partition and portal vein ligation for staged hepatectomy (2018) Surgery (United States), 163 (4), pp. 691-697.

Al Hasan, I., Tun-Abraham, M.E., Wanis, K.N., Garcia-Ochoa, C., Levstik, M.A., Al-Judaibi, B., Hernandez-Alejandro, R. Optimizing associated liver partition and portal vein ligation for staged hepatectomy outcomes: Surgical experience or appropriate patient selection? (2017) Canadian Journal of Surgery, 60 (6), pp. 408-415.

Coffey, J.C., Wanis, K.N., Monbaliu, D., Gilbo, N., Selzner, M., Vachharajani, N., Levstik, M.A., Marquez, M., Doyle, M.B.M., Pirenne, J., Grant, D., Heimbach, J.K., Chapman, W., Vogt, K., Hernandez-Alejandro, R. The influence of functional warm ischemia time on DCD liver transplant recipients’ outcomes

(2017) Clinical Transplantation, 31 (10), art. no. e13068, .

Wanis, K.N., Vinden, C. Metronidazole for Posthemorrhoidectomy Pain: Does No Statistical Significance Mean Insignificant Effect on Pain Relief?: The Authors Reply (2017) Diseases of the Colon and Rectum, 60 (9), p. e618.

Hasselgren, K., Malagò, M., Vyas, S., Campos, R.R., Brusadin, R., Linecker, M., Petrowsky, H., Clavien, P.A., Machado, M.A., Hernandez-Alejandro, R., Wanis, K., Valter, L., Sandström, P., Björnsson, B.

Neoadjuvant chemotherapy does not affect future liver remnant growth and outcomes of associating liver partition and portal vein ligation for staged hepatectomy (2017) Surgery (United States), 161 (5), pp. 1255-1265.

Wanis, K.N., Emmerton-Coughlin, H.M., Coughlin, S., Foley, N., Vinden, C. Systemic Metronidazole May Not Reduce Posthemorrhoidectomy Pain: A Meta-Analysis of Randomized Controlled Trials (2017) Diseases of the Colon and Rectum, 60 (4), pp. 446-455.

Wanis, K.N., Buac, S., Linecker, M., Ardiles, V., Tun-Abraham, M.E., Robles-Campos, R., Malago, M., de Santibañes, E., Clavien, P.-A., Hernandez-Alejandro, R. Patient Survival After Simultaneous ALPPS and Colorectal Resection (2017) World Journal of Surgery, 41 (4), pp. 1119-1125.

Murphy, P.B., Wanis, K., Schlachta, C.M., Alkhamesi, N.A. Systematic review on recent advances in the surgical management of rectal prolapse (2017) Minerva Chirurgica, 72 (1), pp. 71-80.

Wanis, K.N., Patel, S.V.B., Brackstone, M.; Do moderate surgical treatment delays influence survival in colon cancer? (2017) Diseases of the Colon and Rectum, 60 (12), pp. 1241-1249.

Wanis, K.N., Kanthan, R. Diagnostic and prognostic features in adrenocortical carcinoma: A single institution case series and review of the literature (2015) World Journal of Surgical Oncology, 13 (1), art. no. 117, . Cited 20 times.

Wanis, K.N., Hunter, A.M., Harington, M.B., Groot, G. Impact of an acute care surgery service on timeliness of care and surgeon satisfaction at a Canadian academic hospital: A retrospective study

(2014) World Journal of Emergency Surgery, 9 (1), art. no. 4,

Wanis, K., Oucharek, J., Groot, G. Quality of thyroid referrals in Saskatchewan (2013) Quality in Primary Care, 21 (4), pp. 247-252.