Corneal Endothelial Fluid Transport Physiology
Corneal Endothelial Metabolism
Corneal Endothelial Transcriptome
Genetics of Corneal Dystrophies
SLC4A11 membrane transporter
Congenital Hereditary Endothelial Dystrophy (CHED)
Fuch's Endothelial Corneal Dystrophy (FECD)
Sex Differences in Corneal Dystrophies
EyeFind Research Grant, ARVO Foundation for Eye Research / Eye Bank Association of American, $5,000
Pediatric Ophthalmology Career Starter Grant, Knights Templar Eye Foundation, $65,000
Richard Lindstrom Research Grant, Eye Bank Association of America, $5,000
Grants-in-Aid of Research, National Academy of Sciences, Edmond and Marianne Blaauw Ophthalmology Fund, administered by Sigma Xi, the Scientific Research Society, $2,500
Zhang, W., Ogando, D.G., Kim, E.T., Choi, M., Li, H., Tennessen, J.M., Bonanno, J.A., Conditionally immortal Slc4a11-/- mouse corneal endothelial cell line recapitulates disrupted glutaminolysis seen in Slc4a11-/- mouse model. Investigative Ophthalmology & Visual Science 2017; 58: 3723-3731.
Zhang, W., Li, H., Ogando, DG., Li, S., Feng, M., Price, Jr. F.W., Tennessen, J.M., and Bonanno, J.A. "Glutaminolysis is Essential for Energy Production and Ion Transport in Human Corneal Endothelium." EBioMedicine. 16; 292-301, 2017
Zhang, W., Ogando, D.G., Bonanno, J.A., and Obukhov, A.G. "Human SLC4A11 is a Novel NH3: H+ Co-transporter." The Journal of Biological Chemistry 290(27):16894-16905, 2015
Ogando, D.G., Jalimarada, S.S., Zhang, W., Vithana, E.N., and Bonanno, J.A. "SLC4A11 is an EIPA-sensitive Na+ permeable pHi regulator." American Journalof Physiology. Cell Physiology 305(7):C716-727, 2013
Conferences
Dissecting Newly Discovered Corneal Glutamine and Ammonia Metabolism Pathways. American Academy of Optometry (AAO) Annual Meeting 2015, Oct 2015 New Orleans, LA
Glutamine is an essential contributor to the human corneal endothelial ATP pool. Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2015, May 2015 Denver, CO
Characterization of SLC4A11 as a novel ammonia: 2H+ transporter. Experimental Biology 2014, April 2014, San Diego, CA
Seminars
Slc4a11 knock-out model of Endothelial Corneal Dystrophy reveals a phenotype consistent with ammonia toxicity, Oxyopia Seminar, Indiana University School of Optometry, Feb 2016
Glutamine is an essential contributor to the human corneal endothelial ATP pool. Oxyopia Seminar, Indiana University School of Optometry, Jan 2015
Characterize SLC4A11 as a novel NH3/H+ transporter of significant physiological relevance. Oxyopia Seminar, Indiana University School of Optometry, Oct 2013