Publications

2025

Wang K, Rocha K, Zeng Z, Qin H, Ying W. Host Metabolic Inflammation Fueled by Bacterial DNA. Trends in Endocrinology & Metabolism. 2025. 36(8):767-777.

Wang K, Farrel A, Zhou E, Qin H, Zeng Z, Zhou K, Rocha K, Zhang D, Wang G, Atakilit A, Sheppard D, Lu L, Jin C, Ying W. ATF4 drives regulatory T cell functional specification in homeostasis and obesity. Science Immunology. 2025. 10(105):e7193.

Rohm TV, Reis FCG, Karina KC, Isaac R, Strayer S, Murphy C, Bandyopadhyay G, Gao H, Ganguly S, Nguyen T, Wang J, Youhanna JE, Pack D, Liu X, Kim HY, Jeelani I, Dhar D, Kisseleva T, Ying W, Olefsky JM. Adipose tissue macrophages in metabolic dysfunction-associated steatohepatitis secrete extracellular vesicles that activate liver fibrosis in obese male mice. Gastroenterology. 2025. 169(4):691-704.

An G, Song J, Ying W, Lim W. Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases. Molecular & Cellular Toxicology. 2025. 1-11

Rocha KC, Tan B, Kempf J, Medina C, Beldona V, Qian C, Duan Y, Xiang Q, Yoo A, Du X, Majithia AR, Ying W. Adipose tissue macrophage-derived miR-690 modulates adipocyte precursor cell maintenance and adipogenesis. Molecular Metabolism. 2025. 102246

Son S, Xu C, Jang J, Dinh M, Skorobogatko Y, Fu H, Valentine JM, An G, Ying W, Yu RT, Downes M, Evans RM, Saltiel AR. Sympathetic activation of white adipose tissue recruits neutrophils to limit energy expenditure. Nature. 2025. Accepted

Dai J, Zeng Z, Wang L, Yuan W, Rocha KC, Park J, An G, Wang K, Song J, Xiang Q, Duan Y, Qian C, Beldona V, Lim W, Hui E, Karin M, Ying W. Obesity rewires CD8+ T cell iron metabolism in adipose tissue to fuel metabolic inflammation. Metabolism. 2025. Accepted

2024

DS Lark, K Stemmer, W Ying, C Crewe. A brief guide to studying extracellular vesicle function in the context of metabolism. Nat. Metab. 2024. published on Aug 26, 2024

Gao H*, Rocha K*, Jin Z, Kumar D, Zhang D, Wang K, Das M, Farrell A, Truong T, Tekin Y, Jung H, Kempf J, Webster NJ, and Ying W. Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance. Hepatology. 2024. 80(2):363-375 (* co-first authors).

Rohm T, Reis F, Issac R, Murphy C, Rocha K, Bandyopadhyay G, Gao H, Libster A, Zapata R, Lee Y, Ying W, Miciano C, Wang A, and Olefsky JM. Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. Nat. Metab. 2024. 6(5):880-898.

Rocha K, Ying W, and Olefsky JM. Exosome-mediated impact on systemic metabolism. Annu. Rev. Physiol. 2024. 86:225-53.

2023

Gao H*, Wang K*, Suarez JA*, Jin Z, Rocha K, Zhang D, Farrell A, Truong T, Tekin Y, Tan B, Jung HS, Kempf J, Mahata SK, Dillmann WH, Suarez J#, and Ying W#. Gut lumen-leaked microbial DNA causes myocardial inflammation and impairs cardiac contractility in ageing mouse heart. Front. Immunol. 2023 14:1216344. doi: 10.3389/fimmu.2023.1216344. (* co-first authors; # co-corresponding authors)

Li G, Zhu Y, Watari K, Lee M, Liu J, Perez S, et al. Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness . Cell Metab. 2023 Apr 12;S1550-4131(23)00126-2. doi:10.1016/j.cmet.2023.03.021.

2022

Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KCE, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab. 2022 Aug 2;34(8):1201-1213.e5. doi: 10.1016/j.cmet.2022.07.006. PubMed PMID: 35921818; PubMed Central PMCID: PMC9365100.

Gao H, Jin Z, Bandyopadhyay G, Cunha E Rocha K, Liu X, Zhao H, Zhang D, Jouihan H, Pourshahian S, Kisseleva T, Brenner DA, Ying W*, Olefsky JM*. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Cell Metab. 2022 Jul 5;34(7):978-990.e4. doi: 10.1016/j.cmet.2022.05.008. Epub 2022 Jun 13. PubMed PMID: 35700738; PubMed Central PMCID: PMC9262870. (*co-corresponding authors)

Luo Z*, Ji Y*, Zhang D*, Gao H, Jin Z, Yang M, Ying W. Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non-alcoholic steatohepatitis. Acta Physiol (Oxf). 2022 Jul;235(3):e13827. doi: 10.1111/apha.13827. Epub 2022 May 10. PubMed PMID: 35500155; PubMed Central PMCID: PMC9335517. (* co-first authors)

Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, Wang J, Wang E, Caron C, Neben S, Drygin D, Pizzo DP, Wu X, Liu X, Chin AR, Fong MY, Gao Z, Guo K, Fadare O, Schwab RB, Yuan Y, Yost SE, Mortimer J, Zhong W, Ying W, Bui JD, Sears DD, Olefsky JM, Wang SE. Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol. 2022 Jun;24(6):954-967. doi: 10.1038/s41556-022-00919-7. Epub 2022 May 30. PubMed PMID: 35637408; PubMed Central PMCID: PMC9233030.

Gao H, Jin Z, Tang K, Ji Y, Suarez J, Suarez JA, Cunha E Rocha K, Zhang D, Dillmann WH, Mahata SK, Ying W. Microbial DNA Enrichment Promotes Adrenomedullary Inflammation, Catecholamine Secretion, and Hypertension in Obese Mice. J Am Heart Assoc. 2022 Feb 15;11(4):e024561. doi: 10.1161/JAHA.121.024561. Epub 2022 Feb 3. PubMed PMID: 35112881; PubMed Central PMCID: PMC9245808.

Gao H, Luo Z, Ji Y, Tang K, Jin Z, Ly C, Sears DD, Mahata S, Ying W. Accumulation of microbial DNAs promotes to islet inflammation and β cell abnormalities in obesity in mice. Nat Commun. 2022 Jan 28;13(1):565. doi: 10.1038/s41467-022-28239-2. PubMed PMID: 35091566; PubMed Central PMCID: PMC8799656.

Liu MA, Shahabi S, Jati S, Tang K, Gao H, Jin Z, Miller W, Meunier FA, Ying W, van den Bogaart G, Ghosh G, Mahata SK. Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes. Front Endocrinol (Lausanne). 2022;13:1037465. doi: 10.3389/fendo.2022.1037465. eCollection 2022. PubMed PMID: 36440192; PubMed Central PMCID: PMC9691654.

Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022 Aug 9;55(8):1370-1385.e8. doi: 10.1016/j.immuni.2022.06.007. Epub 2022 Jul 13. PubMed PMID: 35835107; PubMed Central PMCID: PMC9378606.

2021

Isaac R, Reis FCG, Ying W, Olefsky JM. Exosomes as mediators of intercellular crosstalk in metabolism. Cell Metab. 2021 Sep 7;33(9):1744-1762. doi: 10.1016/j.cmet.2021.08.006. Review. PubMed PMID: 34496230; PubMed Central PMCID: PMC8428804.

Ji Y, Luo Z, Gao H, Dos Reis FCG, Bandyopadhyay G, Jin Z, Manda KA, Isaac R, Yang M, Fu W, Ying W#, Olefsky JM#. Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075. Nat Metab. 2021 Sep;3(9):1163-1174. doi: 10.1038/s42255-021-00444-1. Epub 2021 Sep 6. PubMed PMID: 34489604; PubMed Central PMCID: PMC8460610. (# co-corresponding authors)

Luo Z, Ji Y, Gao H, Gomes Dos Reis FC, Bandyopadhyay G, Jin Z, Ly C, Chang YJ, Zhang D, Kumar D, Ying W. CRIg+ Macrophages Prevent Gut Microbial DNA-Containing Extracellular Vesicle-Induced Tissue Inflammation and Insulin Resistance. Gastroenterology. 2021 Feb;160(3):863-874. doi: 10.1053/j.gastro.2020.10.042. Epub 2020 Nov 2. PubMed PMID: 33152356; PubMed Central PMCID: PMC7878308.

Muntjewerff EM, Tang K, Lutter L, Christoffersson G, Nicolasen MJT, Gao H, Katkar GD, Das S, Ter Beest M, Ying W, Ghosh P, El Aidy S, Oldenburg B, van den Bogaart G, Mahata SK. Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides. Acta Physiol (Oxf). 2021 Jun;232(2):e13655. doi: 10.1111/apha.13655. Epub 2021 May 6. PubMed PMID: 33783968; PubMed Central PMCID: PMC8341099.

Ying W, Tang K, Avolio E, Schilling JM, Pasqua T, Liu MA, Cheng H, Gao H, Zhang J, Mahata S, Ko MS, Bandyopadhyay G, Das S, Roth DM, Sahoo D, Webster NJG, Sheikh F, Ghosh G, Patel HH, Ghosh P, van den Bogaart G, Mahata SK. Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin). Hypertension. 2021 May 5;77(5):1670-1682. doi: 10.1161/HYPERTENSIONAHA.120.16809. Epub 2021 Apr 7. PubMed PMID: 33826401; PubMed Central PMCID: PMC8116433.

Ying W#, Gao H, Dos Reis FCG, Bandyopadhyay G, Ofrecio JM, Luo Z, Ji Y, Jin Z, Ly C, Olefsky JM#. MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice. Cell Metab. 2021 Apr 6;33(4):781-790.e5. doi: 10.1016/j.cmet.2020.12.019. Epub 2021 Jan 14. PubMed PMID: 33450179; PubMed Central PMCID: PMC8035248. (# co-corresponding authors)

Gao H, Luo Z, Jin Z, Ji Y, Ying W. Adipose Tissue Macrophages Modulate Obesity-Associated β Cell Adaptations through Secreted miRNA-Containing Extracellular Vesicles. Cells. 2021 Sep 17;10(9). doi: 10.3390/cells10092451. PubMed PMID: 34572101; PubMed Central PMCID: PMC8472266.

2020

Ying W, Fu W, Lee YS, Olefsky JM. The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities. Nat Rev Endocrinol. 2020 Feb;16(2):81-90. doi: 10.1038/s41574-019-0286-3. Epub 2019 Dec 13. Review. PubMed PMID: 31836875; PubMed Central PMCID: PMC8315273.

2019

Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W. Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity. Cell Metab. 2019 Feb 5;29(2):457-474.e5. doi: 10.1016/j.cmet.2018.12.003. Epub 2018 Dec 27. PubMed PMID: 30595478; PubMed Central PMCID: PMC6701710.

Wollam J, Riopel M, Xu YJ, Johnson AMF, Ofrecio JM, Ying W, El Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN, Lee YS, Watrous JD, Chordia MD, Pan D, Jain M, Olefsky JM. Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. Diabetes. 2019 Jul;68(7):1415-1426. doi: 10.2337/db18-1307. Epub 2019 Apr 22. PubMed PMID: 31010956; PubMed Central PMCID: PMC6609982.

2018

Hernandez-Carretero A, Weber N, La Frano MR, Ying W, Lantero Rodriguez J, Sears DD, Wallenius V, Börgeson E, Newman JW, Osborn O. Obesity-induced changes in lipid mediators persist after weight loss. Int J Obes (Lond). 2018 Apr;42(4):728-736. doi: 10.1038/ijo.2017.266. Epub 2017 Nov 1. PubMed PMID: 29089614; PubMed Central PMCID: PMC6055936.

Ying W, Mahata S, Bandyopadhyay GK, Zhou Z, Wollam J, Vu J, Mayoral R, Chi NW, Webster NJG, Corti A, Mahata SK. Catestatin Inhibits Obesity-Induced Macrophage Infiltration and Inflammation in the Liver and Suppresses Hepatic Glucose Production, Leading to Improved Insulin Sensitivity. Diabetes. 2018 May;67(5):841-848. doi: 10.2337/db17-0788. Epub 2018 Feb 6. PubMed PMID: 29432123; PubMed Central PMCID: PMC6463753.

2017

Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, Li P, Olefsky JM. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Cell. 2017 Oct 5;171(2):372-384.e12. doi: 10.1016/j.cell.2017.08.035. Epub 2017 Sep 21. PubMed PMID: 28942920.

Ying W, Wollam J, Ofrecio JM, Bandyopadhyay G, El Ouarrat D, Lee YS, Oh DY, Li P, Osborn O, Olefsky JM. Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest. 2017 Mar 1;127(3):1019-1030. doi: 10.1172/JCI90350. Epub 2017 Feb 13. PubMed PMID: 28192375; PubMed Central PMCID: PMC5330737.

MicroRNA-Regulated Immune Cell Function in Obese Adipose Tissue. In: Handbook of Nutrition, Diet, and Epigenetics Cham: Springer; 2017. p.1-18.

Li C, Ying W, Huang Z, Brehm T, Morin A, Vella AT, Zhou B. IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages. Endocrinology. 2017 Sep 1;158(9):2837-2847. doi: 10.1210/en.2017-00053. PubMed PMID: 28645193; PubMed Central PMCID: PMC5659664.

Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata SK. Diabetic Cardiomyopathy: An Immunometabolic Perspective. Front Endocrinol (Lausanne). 2017;8:72. doi: 10.3389/fendo.2017.00072. eCollection 2017. Review. PubMed PMID: 28439258; PubMed Central PMCID: PMC5384479.

2016

Ying W, Tseng A, Chang RC, Wang H, Lin YL, Kanameni S, Brehm T, Morin A, Jones B, Splawn T, Criscitiello M, Golding MC, Bazer FW, Safe S, Zhou B. miR-150 regulates obesity-associated insulin resistance by controlling B cell functions. Sci Rep. 2016 Feb 1;6:20176. doi: 10.1038/srep20176. PubMed PMID: 26833392; PubMed Central PMCID: PMC4735333.

Li P, Liu S, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson AMF, Sears D, Shen Z, Cui B, Kong L, Hou S, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016 Nov 3;167(4):973-984.e12. doi: 10.1016/j.cell.2016.10.025. PubMed PMID: 27814523; PubMed Central PMCID: PMC5179329.

Shi L, Kim AJ, Chang RC, Chang JY, Ying W, Ko ML, Zhou B, Ko GY. Deletion of miR-150 Exacerbates Retinal Vascular Overgrowth in High-Fat-Diet Induced Diabetic Mice. PLoS One. 2016;11(6):e0157543. doi: 10.1371/journal.pone.0157543. eCollection 2016. PubMed PMID: 27304911; PubMed Central PMCID: PMC4909316.

2015

Ying W, Tseng A, Chang RC, Morin A, Brehm T, Triff K, Nair V, Zhuang G, Song H, Kanameni S, Wang H, Golding MC, Bazer FW, Chapkin RS, Safe S, Zhou B. MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation. J Clin Invest. 2015 Nov 2;125(11):4149-59. doi: 10.1172/JCI81656. Epub 2015 Oct 5. PubMed PMID: 26436647; PubMed Central PMCID: PMC4639972.

Bazer FW, Ying W, Wang X, Dunlap KA, Zhou B, Johnson GA, Wu G. The many faces of interferon tau. Amino Acids. 2015 Mar;47(3):449-60. doi: 10.1007/s00726-014-1905-x. Epub 2015 Jan 4. Review. PubMed PMID: 25557050.

2014

Ying W, Wang H, Bazer FW, Zhou B. Pregnancy-secreted Acid phosphatase, uteroferrin, enhances fetal erythropoiesis. Endocrinology. 2014 Nov;155(11):4521-30. doi: 10.1210/en.2014-1397. Epub 2014 Aug 5. PubMed PMID: 25093463; PubMed Central PMCID: PMC4197981.

Chang RC, Ying W, Bazer FW, Zhou B. MicroRNAs Control Macrophage Formation and Activation: The Inflammatory Link between Obesity and Cardiovascular Diseases. Cells. 2014 Jul 10;3(3):702-12. doi: 10.3390/cells3030702. PubMed PMID: 25014161; PubMed Central PMCID: PMC4197627.

Ying W, Kanameni S, Chang CA, Nair V, Safe S, Bazer FW, Zhou B. Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization. PLoS One. 2014;9(6):e98835. doi: 10.1371/journal.pone.0098835. eCollection 2014. PubMed PMID: 24905566; PubMed Central PMCID: PMC4048269.

Wang X, Ying W, Dunlap KA, Lin G, Satterfield MC, Burghardt RC, Wu G, Bazer FW. Arginine decarboxylase and agmatinase: an alternative pathway for de novo biosynthesis of polyamines for development of mammalian conceptuses. Biol Reprod. 2014 Apr;90(4):84. doi: 10.1095/biolreprod.113.114637. Print 2014 Apr. PubMed PMID: 24648395.

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