Publications
Data Papers
Hu Y, Ferrario CR, Maitland AD, Ionides RB, Ghimire A, Watson B, Iwasaki K, White H, Xi Y, Zhou J, Ye B. LabGym: Quantification of user-defined animal behaviors using learning-based holistic assessment
Cell Rep Methods. 2023 Feb 24;3(3):100415. doi: 10.1016/j.crmeth.2023.100415. Link
Bueno LS, Jones-Tinsley CE, Milman NEP, Wickham PT, Watson BO*, Lim MM*. Early-life sleep disruption impairs subtle social behaviours in prairie voles: a pose-estimation study. Royal Soc. Open Sci 10 (7). https://doi.org/10.1098/rsos.230700. Link
Bueno LS, Rucksthul MS, Lim MM, Watson BO (2023). The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans. Proc Nat Acad Sci 120(18). https://doi.org/10.1073/pnas.2213438120. Link
Yi D*, Hartner JD*, Ung BS, Zhu HL, Watson BO#, Chen L# (2022). 3D printed skull cap and benchtop fabricated microwire-based microelectrode array for custom rat brain recordings. Bioengineering 9(10), 550. doi: https://doi.org/10.3390/bioengineering9100550. Link
Tsimpanouli ME, Ghimire A, Barget A, Weston R, Paulson HL, Costa MDC, Watson BO. Sleep Alterations in a Mouse Model of Spinocerebellar Ataxia Type 3. Cells 2022 Oct; 11(19), 3132. doi: https://doi.org/10.3390/cells11193132. Link
Chen L, Hartner J, Dong T, Li A, Watson, B, Shih, A. Flexible High-Resolution Force and Dimpling Measurement System for Pia and Dura Penetration During In Vivo Microelectrode Insertion Into Rat Brain. 2021 Aug;68(8):2602-2612. doi: 10.1109/TBME.2021.3070781. Epub 2021 Jul 16. Link
Fitzgerald PJ, Hale PJ, Ghimire A, Watson BO. Multiple cholinesterase inhibitors have antidepressant-like properties in the mouse forced swim test. Behav Brain Res. 2021 Apr 25;409:113323. doi: 10.1016/j.bbr.2021.113323. Link
Fitzgerald, P.J, Kounelis-Wuillaume, S.K., Gheidi, A, Morrow, JD, Spencer-Segal, JL, Watson, BO (2021). Sex- and stress-dependent effects of a single injection of ketamine on open field and forced swim behavior. Stress. 1;1-9. doi: 10.1080/10253890.2021.1871600. Link.
Fitzgerald PJ, Hale PJ, Ghimire A, Watson BO (2020). The cholinesterase inhibitor donepezil has antidepressant-like properties in the mouse forced swim test. Translational Psychiatry. 10: 255. Link
Fitzgerald, P.J., Yen, J.Y., Watson, B.O. (2019). Stress-sensitive antidepressant-like effects of ketamine in the mouse forced swim test. PLOS ONE 2019 Apr 15;14(4):e0215554. doi: 10.1371/journal.pone.0215554. Link
Miyawaki, H., Watson, B.O., Diba, K (2019). Neuronal firing rates diverge during REM and homogenize during non-REM (2019). Scientific Reports 9(1):689. PDF
Watson, B.O., Ding, M., Buzsaki, G. (2018). Temporal coupling of field potentials and action potentials in the neocortex. Eur J. Neurosci 48(7):2482-2497. PDF
Watson, B.O., Levenstein, D., Greene, J.P., Gelinas, J.N., Buzsaki, G (2016). Network homeostasis and state dynamics of neocortical sleep. Neuron 90(4): 839-852. PDF
Cohen, S.M., Ma, H., Kuchibhotla, K., Watson, B.O., Buzsaki, G., Froemke, R., Tsien, R.W. (2016). Excitation-transcription coupling in parvalbumin-positive interneurons employs a novel CaM Kinase-dependent pathway distinct from excitatory neurons. Neuron 90(2): 292-307. PDF
Vandecasteele, M., Royer, S., Belluscio, M., Diba, K., Fujisawa, S., Grosmark, A., Mao, D,.Mizuseki, K., Patel, J., Stark, E., Sullivan, D., Watson, B., Buzsaki, G. (2012). Large-scaleRecording of Neurons by Movable Silicon Probes in Behaving Rodents. J Vis Exp 61 pii:3568. doi: 10.3791/3568. LINK
Watson, B.O., Nikolenko, V., Yuste, R. (2009). Two photon imaging with diffractive optical elements. Frontiers in Neural Circuits 3:6. PDF
Vogelstein, J., Watson, B.O., Packer, A.M., Yuste, R., Jedyank, B. and Paninski, L. (2009). Spike inference from calcium imaging using sequential Monte Carlo methods. Biophysical Journal 97(2):636-55. PDF
Watson, B.O., MacLean, J.N., and Yuste, R.. (2008). UP states protect cortical dynamics from thalamic inputs. PLoS One 3(12):e3971. PDF
Nikolenko, V., Watson B.O., Araya, R., Woodruff, A., Peterka, D.S., and Yuste, R. (2008). SLM Microscopy: Scanless Two-photon Imaging and Photostimulation with SpatialLight Modulators. Frontiers in Neural Circuits. 2:5. Epub 2008 Dec 19. PDF
Trevelyan, A.J., Sussillo, D., Watson, B.O., and Yuste R (2006). Modular propagation of epileptiform activity: Evidence for an inhibitory veto in neocortex. Journal of Neuroscience 2006 Nov 29;26(48):12447-55. PDF
MacLean, J.N., Fenstermaker, V., Watson, B.O., and Yuste, R. (2006). A visual thalamocortical slice. Nature Methods, 3: 129-34. PDF
MacLean, J.N., Watson, B.O., Aaron, G.B., and Yuste, R. (2005). Internal dynamics determine the cortical response to thalamic stimulation. Neuron, 48: 811-823. PDF
Fernandez, J.M., Watson, B., and Qian, N. (2002). Computing relief structure from motion with a distributed velocity and disparity representation. Vision Research, 42: 883-898. PDF
Rao S.S., Stewart B.A., Rivlin P.K., Vilinsky I., Watson B.O., Lang C., Boulianne G.,Salpeter M.M., Deitcher D.L. (2001). Two distinct effects on neurotransmission in a temperature-sensitive SNAP-25 mutant. EMBO Journal, 20(23) 6761-71. PDF
Watson, B.O., Vilinsky, I., and Deitcher, D.L. (2001). Generation of a semi-dominant mutation with temperature sensitive effects on both locomotion and phototransduction in Drosophila melanogaster. Journal of Neurogenetics, 15: 75-95. PDF
Watson, B., Meng, F., and Akil, H. (1996). A chimeric analysis of the opioid receptor domains critical for the binding selectivity of mu opioid ligands. Neurobiology of Disease, 3:87–96, 1996. PDF
Reviews and Invited Papers
Weston RG, Fitzgerald PJ, and Watson BO (2021). Repeated Dosing of Ketamine in the Forced Swim Test: Are Multiple Shots Better Than One? Front. Psychiatry, 11 May 2021 (DOI). Link
Fitzgerald, PJ, Hale, PJ, Ghimire, A, Watson, BO (2021). Repurposing cholinesterase inhibitors as antidepressants? Dose and stress-sensitivity may be critical to opening possibilities. Frontiers in Behavioral Neuroscience. 2021 Jan 14;14:620119. Link
Liu, TY, Watson, BO (2020). Patterned activation of action potential patterns during offline states in the neocortex: replay and non-replay. Philos Trans R Soc Lond B Biol Sci. 2020 May 25;375(1799):20190233. Link
Polis AJ, Fitzgerald PJ, Hale PJ, Watson BO (2019). Rodent ketamine depression-related research: Finding patterns in a literature of variability. Behav Brain Res. Link
Fitzgerald, P.J. and Watson B.O. (2019). In vivo electrophysiological recordings of the effects of antidepressant drugs. Experimental Brain Research. Link
Watson, B.O. (2018). Cognitive and Physiologic Impacts of the Infraslow Oscillation. Front. Syst. Neurosci., 16 October 2018. Link
Fitzgerald, P.J. and Watson B.O. (2018). Gamma oscillations as a biomarker for major depression: an emerging topic. Translational Psychiatry 8:177. PDF
Levenstein, D., Watson B.O., Rinzel, J., Buzsaki, G. (2017). Sleep regulation of the distribution of cortical firing rates. Current Opinion in Neurobiology 44:34-42. PDF
Watson, B.O., Buzsaki, G. (2014). Sleep, Memory and Brain Rhythms. Daedalus 141.1(2015): 67-82. PDF
Watson, B.O., Michels R.M. (2014). Neuroscience in the Residency Curriculum: The Psychoanalytic Psychotherapy Perspective. Academic Psychiatry, 28(2):124-6. PDF
Buzsaki, G., Watson, B.O. (2012). Brain rhythms and neural syntax: implications for efficient coding of cognitive content and neuropsychiatric disease. Dialogues in Clinical Neuroscience 14(4):345-67. PDF
Watson, B.O., Nikolenko, V., Araya, , R., Peterka, D.S., Yuste, R (2010). Two-photon microscopy with diffractive optical elements and spatial light modulators. Front. Neurosci. 15;4. pii: 29. PDF
Clinical Papers
Sagar V Parikh 1, Daniela Lopez 1, Jennifer L Vande Voort 1, Jose Rico 1, Eric Achtyes 1, William Coryell 1, Andrew Goddard 1, Fernando Goes 1, John F Greden 1, Balwinder Singh 1, Adam Kaplin 1, Mark A Frye 1, Daniel Maixner 1, Brendon Watson 1, Karina Drake 1, Vijay Tarnal 1, Patricio Riva-Posse 1, William V Bobo 1, Bio-K Study Team 1 Developing an IV Ketamine Clinic for Treatment-Resistant Depression: a Primer. Psychopharmacol Bull. 2021 Jun 1;51(3):109-124.
Published and Shared Code
Buzcode: a code library for electrophysiologic data analysis. I am part of a consortium of contributors including the lab of Gyorgy Buzsaki.
My other code repositories for electrophysiologic data
Watson, B.O. Yuste, R, Packer, A (2016). PackIO and EphysViewer: software tools for acquisition and analysis of neuroscience data.