Data Papers

Bueno LS, Jones-Tinsley CE, Milman NEP, Wickham PT, Watson BO, Lim MM.  Early-life sleep disruption impairs subtle social behaviours in prairie voles: a pose-estimation study. Royal Soc. Open Sci 10 (7).

Bueno LS, Rucksthul MS, Lim MM, Watson BO (2023).  The temporal structure of REM sleep shows minute-scale fluctuations across brain and body in mice and humans.  Proc Nat Acad Sci 120(18). Link

Yi D*, Hartner JD*, Ung BS, Zhu HL, Watson BO, Chen L (2022).  3D printed skull cap and benchtop fabricated microwire-based microelectrode array for custom rat brain recordings.  Bioengineering  9(10), 550.  doi:

Tsimpanouli ME, Ghimire A, Barget A, Weston R, Paulson HL, Costa MDC, Watson BO.  Sleep Alterations in a Mouse Model of Spinocerebellar Ataxia Type 3.  Cells 2022 Oct; 11(19), 3132.  doi:

Chen L, Hartner J, Dong T, Li A, Watson, B, Shih, A.  Flexible High-Resolution Force and Dimpling Measurement System for Pia and Dura Penetration During In Vivo Microelectrode Insertion Into Rat Brain. 2021 Aug;68(8):2602-2612. doi: 10.1109/TBME.2021.3070781. Epub 2021 Jul 16.  Link

Fitzgerald PJ, Hale PJ, Ghimire A, Watson BO.  Multiple cholinesterase inhibitors have antidepressant-like properties in the mouse forced swim test.  Behav Brain Res. 2021 Apr 25;409:113323. doi: 10.1016/j.bbr.2021.113323.  Link

Fitzgerald, P.J, Kounelis-Wuillaume, S.K., Gheidi, A, Morrow, JD, Spencer-Segal, JL, Watson, BO (2021).  Sex- and stress-dependent effects of a single injection of ketamine on open field and forced swim behavior. Stress. 1;1-9. doi: 10.1080/10253890.2021.1871600Link.

Fitzgerald PJ, Hale PJ, Ghimire A, Watson BO (2020).  The cholinesterase inhibitor donepezil has antidepressant-like properties in the mouse forced swim test. Translational Psychiatry. 10: 255. Link

Fitzgerald, P.J., Yen, J.Y., Watson, B.O. (2019).  Stress-sensitive antidepressant-like effects of ketamine in the mouse forced swim test.  PLOS ONE 2019 Apr 15;14(4):e0215554. doi: 10.1371/journal.pone.0215554Link

Miyawaki, H., Watson, B.O., Diba, K (2019).  Neuronal firing rates diverge during REM and homogenize during non-REM (2019).  Scientific Reports 9(1):689.  PDF

Watson, B.O., Ding, M., Buzsaki, G. (2018).  Temporal coupling of field potentials and action potentials in the neocortex.  Eur J. Neurosci 48(7):2482-2497.  PDF

Watson, B.O., Levenstein, D., Greene, J.P., Gelinas, J.N., Buzsaki, G (2016).  Network homeostasis and state dynamics of neocortical sleep.  Neuron 90(4): 839-852.  PDF

Cohen, S.M., Ma, H., Kuchibhotla, K., Watson, B.O., Buzsaki, G., Froemke, R., Tsien, R.W. (2016). Excitation-transcription coupling in parvalbumin-positive interneurons employs a novel CaM Kinase-dependent pathway distinct from excitatory neurons.  Neuron 90(2): 292-307.  PDF

Vandecasteele, M., Royer, S., Belluscio, M., Diba, K., Fujisawa, S., Grosmark, A., Mao, D,.Mizuseki, K., Patel, J., Stark, E., Sullivan, D., Watson, B., Buzsaki, G. (2012).  Large-scaleRecording of Neurons by Movable Silicon Probes in Behaving Rodents.  J Vis Exp 61 pii:3568. doi: 10.3791/3568.  LINK

Watson, B.O., Nikolenko, V., Yuste, R. (2009).  Two photon imaging with diffractive optical elements.  Frontiers in Neural Circuits 3:6. PDF

Vogelstein, J., Watson, B.O., Packer, A.M., Yuste, R., Jedyank, B. and Paninski, L. (2009). Spike inference from calcium imaging using sequential Monte Carlo methods. Biophysical Journal 97(2):636-55.  PDF

Watson, B.O., MacLean, J.N., and Yuste, R.. (2008).  UP states protect cortical dynamics from thalamic inputs.  PLoS One 3(12):e3971.  PDF

Nikolenko, V., Watson B.O., Araya, R., Woodruff, A., Peterka, D.S., and Yuste, R. (2008). SLM Microscopy: Scanless Two-photon Imaging and Photostimulation with SpatialLight Modulators. Frontiers in Neural Circuits. 2:5. Epub 2008 Dec 19.  PDF

Trevelyan, A.J.,  Sussillo, D.,  Watson, B.O., and Yuste R (2006).  Modular propagation of epileptiform activity: Evidence for an inhibitory veto in neocortex.  Journal of Neuroscience 2006 Nov 29;26(48):12447-55.  PDF

MacLean, J.N., Fenstermaker, V., Watson, B.O., and Yuste, R. (2006).  A visual thalamocortical slice. Nature Methods, 3: 129-34.  PDF

MacLean, J.N., Watson, B.O., Aaron, G.B., and Yuste, R. (2005).  Internal dynamics determine the cortical response to thalamic stimulation.  Neuron, 48: 811-823.  PDF

Fernandez, J.M., Watson, B., and Qian, N. (2002).  Computing relief structure from motion with a distributed velocity and disparity representation.  Vision Research, 42: 883-898. PDF

Rao S.S., Stewart B.A., Rivlin P.K., Vilinsky I., Watson B.O., Lang C., Boulianne G.,Salpeter M.M., Deitcher D.L. (2001).  Two distinct effects on neurotransmission in a temperature-sensitive SNAP-25 mutant.  EMBO Journal, 20(23) 6761-71.  PDF

Watson, B.O., Vilinsky, I., and Deitcher, D.L. (2001).  Generation of a semi-dominant mutation with temperature sensitive effects on both locomotion and phototransduction in Drosophila melanogaster.  Journal of Neurogenetics, 15: 75-95. PDF

Watson, B., Meng, F., and Akil, H. (1996).    A chimeric analysis of the opioid receptor domains critical for the binding selectivity of mu opioid ligands. Neurobiology of Disease, 3:87–96, 1996. PDF

Reviews and Invited Papers

Weston RG, Fitzgerald PJ, and Watson BO (2021). Repeated Dosing of Ketamine in the Forced Swim Test: Are Multiple Shots Better Than One?  Front. Psychiatry, 11 May 2021 (DOI). Link 

Fitzgerald, PJ, Hale, PJ, Ghimire, A, Watson, BO (2021).  Repurposing cholinesterase inhibitors as antidepressants? Dose and stress-sensitivity may be critical to opening possibilities.  Frontiers in Behavioral Neuroscience.  2021 Jan 14;14:620119. Link

Liu, TY, Watson, BO (2020).  Patterned activation of action potential patterns during offline states in the neocortex: replay and non-replay.  Philos Trans R Soc Lond B Biol Sci. 2020 May 25;375(1799):20190233. Link

Polis AJ, Fitzgerald PJ, Hale PJ, Watson BO (2019).  Rodent ketamine depression-related research: Finding patterns in a literature of variability.  Behav Brain Res.  Link

Fitzgerald, P.J. and Watson B.O. (2019).  In vivo electrophysiological recordings of the effects of antidepressant drugs.  Experimental Brain ResearchLink

Watson, B.O. (2018).  Cognitive and Physiologic Impacts of the Infraslow Oscillation.  Front. Syst. Neurosci., 16 October 2018.  Link

Fitzgerald, P.J. and Watson B.O. (2018).  Gamma oscillations as a biomarker for major depression: an emerging topic.  Translational Psychiatry 8:177.  PDF

Levenstein, D., Watson B.O., Rinzel, J., Buzsaki, G. (2017).  Sleep regulation of the distribution of cortical firing rates.  Current Opinion in Neurobiology 44:34-42.   PDF

Watson, B.O., Buzsaki, G. (2014). Sleep, Memory and Brain Rhythms.  Daedalus 141.1(2015): 67-82.  PDF

Watson, B.O., Michels R.M. (2014). Neuroscience in the Residency Curriculum: The Psychoanalytic Psychotherapy Perspective.  Academic Psychiatry, 28(2):124-6.  PDF

Buzsaki, G., Watson, B.O. (2012).  Brain rhythms and neural syntax: implications for efficient coding of cognitive content and neuropsychiatric disease.  Dialogues in Clinical Neuroscience 14(4):345-67.  PDF

Watson, B.O., Nikolenko, V., Araya, , R., Peterka, D.S., Yuste, R (2010).  Two-photon microscopy with diffractive optical elements and spatial light modulators.  Front. Neurosci. 15;4. pii: 29. PDF

Clinical Papers

Sagar V Parikh 1, Daniela Lopez 1, Jennifer L Vande Voort 1, Jose Rico 1, Eric Achtyes 1, William Coryell 1, Andrew Goddard 1, Fernando Goes 1, John F Greden 1, Balwinder Singh 1, Adam Kaplin 1, Mark A Frye 1, Daniel Maixner 1, Brendon Watson 1, Karina Drake 1, Vijay Tarnal 1, Patricio Riva-Posse 1, William V Bobo 1, Bio-K Study Team 1  Developing an IV Ketamine Clinic for Treatment-Resistant Depression: a Primer.  Psychopharmacol Bull. 2021 Jun 1;51(3):109-124.

Published and Shared Code

Buzcode: a code library for electrophysiologic data analysis.  I am part of a consortium of contributors including the lab of Gyorgy Buzsaki.  

My other code repositories for electrophysiologic data

Watson, B.O. Yuste, R, Packer, A (2016).  PackIO and EphysViewer: software tools for acquisition and analysis of neuroscience data.