Our lab's primary interest is in high resolution structural studies on pathogenic viruses, their antigenic determinants and modes of cellular infection. We primarily use cryo-electron microscopy (cryo-EM) methods such as cryo-electron tomography, sub-tomogram averaging and single particle cryo-EM for our research along with other molecular and biophysical tools.
Embedded Files
Enveloped RNA viruses have been responsible for major epidemics in humans in the past century. We still lack mechanistic details on many of these virus structures, their antigenic determinants and their modes of cellular infection. Our lab is interested in using high resolution structural methods to study various aspects of pathogenic RNA viruses. Our current interests span flaviviruses such as dengue virus, Zika virus and Japanese encephalitis viruses; influenza virus and SARS-CoV2.
We primarily use TEM methods such as single-particle cryo-EM, cryo-electron tomography, sub-tomogram averaging and cell-sectioning, along with biophysical and biochemical tools. A big advantage of cryo-EM is that it can accommodate conformational heterogeneity in biological samples. With advancements in cryo-electron tomography and sub-tomogram averaging methods, it is now also possible to image and calculate structures of macromolecules in complex and heterogenous environments. In our lab, we are leveraging these methodologies to advance our mechanistic understanding of viral infections.
Structures Gallery:
Structures Gallery:
movie-ed.mp4Google Sites
Report abuse