Our lab's primary interest is in high resolution structural studies on pathogenic viruses, their antigenic determinants and modes of cellular infection. We primarily use cryo-electron microscopy (cryo-EM) methods such as cryo-electron tomography, sub-tomogram averaging and single particle cryo-EM for our research along with other molecular and biophysical tools.
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Flaviviruses are a group of small, icosahedral RNA viruses with a huge disease burden. These include well-known human pathogens such as dengue virus, Zika virus, West Nile virus, Japanese encephalitis virus, yellow fever virus and several others. Our lab is interested in structurally characterizing the cellular entry mechanisms of this medically important virus family using cryo-EM methods.
A primary advantage of cryo-EM is that it can accommodate conformational heterogeneity in biological samples. With advancements in cryo-electron tomography and sub-tomogram averaging methods, it is now also possible to image and calculate structures of macromolecules in complex and heterogenous environments. In our lab, we are leveraging these methodologies to advance our mechanistic understanding of viral infections.
Structures Gallery:
Structures Gallery:
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