Research
Click Chemistry
We are working towards developing a variety of physically cross-linked, pH-sensitive SMART hydrogels and their nano-composites with tunable formulations, possessing microporous interiors, resembling a honeycomb framework, with a continuous skin on the surface using different variety of monomers. Our formulations, being devoid of any chemical cross linkers found to be highly biocompatible, which opens a gateway for a myriad of biomedical applications. A significant effort is dedicated to devising new synthetic routes to functional macromolecules. In addition to relying on living/controlled radical polymerization techniques to prepare polymers of controlled molecular weight and retained end group functionality, highly efficient postpolymerization modification is required to incorporate functionality not easily included in the monomer, initiator, or chain transfer agents. Many chemical transformations employed in organic synthesis do not demonstrate the same degree of efficiency and orthogonality when used for the functionalization of high molecular weight macromolecules. Therefore, a significant effort in our group has involved the extension of "click chemistry" methodologies for functional polymer synthesis.
Functional polymer synthesis and efficient polymer modification via specific and orthogonal methodologies
A significant effort is dedicated to devising new synthetic routes to functional macromolecules. In addition to relying on living/controlled radical polymerization techniques to prepare polymers of controlled molecular weight and retained end group functionality, highly efficient postpolymerization modification is required to incorporate functionality not easily included in the monomer, initiator, or chain transfer agents. Many chemical transformations employed in organic synthesis do not demonstrate the same degree of efficiency and orthogonality when used for the functionalization of high molecular weight macromolecules. Therefore, a significant effort in our group has involved the extension of "click chemistry" methodologies for functional polymer synthesis.
Stimuli-responsive water-soluble block copolymers
The solution behavior of polymers that exhibit "smart" behavior in aqueous media is being investigated. Responsive block copolymers can be induced to form micelles, vesicles, or gels, and may ultimately lead to new applications in controlled drug delivery, tissue engineering, and surface biocompatibilization. We are also involved in environmentally effective polymers which change their phase with the effect of temperature, pH, Light, magnetic, etc (https://doi.org/10.1039/C3PY01648J). We can design polymers according to the requirements and appropriate stimuli. We also checked the solution concentration effect on the synthesis of clickable polymers to obtain intermolecular or/and intramolecular polymers (https://link.springer.com/article/10.1134%2FS1560090419060095).
Time‐Dependent Sustained Drug Release
We are engaged in designing several unique framework of hydrogels which have good controllability for releasing the drug (https://doi.org/10.1002/marc.201300585). We are also involved in target specific drug release using magnetic nanogels.
Magnetic Nanocatalysts
The application of magnetic nanocatalysts is a rapidly growing field for the development of sustainable and green processes. Magnetic separation not only avoids the need for catalyst filtration or centrifugation after completion of the reaction, but also provides practical techniques for recovering these catalysts.
Waste as a resource
A fast developing country like India generates various kinds of urban and industrial waste. The range of waste streams includes - municipal waste, construction and demolition debris, plastic packaging waste, e-waste, industrial hazardous and non-hazardous waste and biomedical waste. These waste streams provide a unique challenge for their management.
Water remediation, Dye Removal and degradation
In this, scattered information of research work carried out by many researchers related to various methods for the removal of cationic dyes especially Rhodamine-B, Methylene Blue, Crystal Violet, Malachite Green and Safranin-O dye present in textile effluent have been compiled and compared to find out cheap and effective method by calculating their percentage removal.
Multicomponent Reactions (MCR) and Catalysis
We are working on the one-pot synthesis of ring hydrogenated Carbamates from aromatic amines and organic carbonates under hydrogen atmosphere (https://doi.org/10.1016/j.apcata.2014.09.013). We also go further one pot synthesis of disubstituted Urea and Carbamates through utilization of CO2, Propylene Oxide, and Amines by using Ionic liquid based Homo-and heterogeneous catalysis system (https://doi.org/10.1002/bkcs.11363) (https://patents.google.com/patent/US9273016B2/en). and did one pot catalytic NO2 reduction, ring hydrogenation and N-alkylation from nitroarene to alicyclic amines using ruthenium based catalysts.(https://doi.org/10.1016/j.catcom.2013.09.012).