Vitamin D deficiency

UNDER CONSTRUCTION!

According to the Harvard Medical School : "Vitamin D is not one chemical but many. The natural type is produced in the skin from a universally present form of cholesterol, 7-dehydrocholesterol. Sunlight is the key: Its ultraviolet B (UVB) energy converts the precursor to vitamin D3. In contrast, most dietary supplements are manufactured by exposing a plant sterol to ultraviolet energy, thus producing vitamin D2. Because their function is almost identical, D2 and D3 are lumped together under the name vitamin D — but neither will function until the body works its magic.

Vitamin D deficiencies were rare when most men rolled up their sleeves to work in sunny fields. But as work shifted from farms to offices, that changed. Because pigmentation can reduce vitamin D production in the skin by over 90%, nonwhite populations are at particular risk. Deficiencies are also common in patients with intestinal disorders that limit absorption of fat and those with kidney or liver diseases that reduce the conversion of vitamin D to its active form, calcitriol (1,25(OH)2D). In addition, certain medications reduce the availability or activity of vitamin D. And even in healthy people, advancing age is linked to an increased risk of vitamin D deficiency." Vitamin D and your health: Breaking old rules, raising new hopes

We also know, that Vitamin D deficiency may be associated with lower level of HDL-cholesterol and higher ratio of total cholesterol to HDL. "...Deficient 25(OH)D was prospectively associated with lower TC and HDL-C and a greater ratio of TC to HDL-C after considering factors such as diabetes and adiposity. " https://www.ncbi.nlm.nih.gov/pubmed/28526388

That means you can consider with your doctor to test simultaneously an HDL level with the 25-OH/1,25-Dihydroxy test to find a potential cause of Vitamin D deficiency! It's very logical, because human skin synthesizes vitamin D3 (called cholecalciferol) from derivative of the steroid cholesterol.

...The presence of vitamin D receptors throughout the brain suggests that it may directly affect brain tissue,

"...In the last decades, several studies were conducted which shows the association between vitamin D and brain health and the impact of vitamin D deficiency on the brain." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132681/

"The vitamin D receptor (VDR) is a nuclear, ligand-dependent transcription factor that in complex with hormonally active vitamin D, 1,25(OH)2D3, regulates the expression of more than 900 genes involved in a wide array of physiological functions. The impact of 1,25(OH)2D3-VDR signaling on immune function has been the focus of many recent studies as a link between 1,25(OH)2D3 and susceptibility to various infections and to development of a variety of inflammatory diseases has been suggested. It is also becoming increasingly clear that microbes slow down immune reactivity by dysregulating the VDR ultimately to increase their chance of survival. Immune modulatory therapies that enhance VDR expression and activity are therefore considered in the clinic today to a greater extent. As T cells are of great importance for both protective immunity and development of inflammatory diseases a variety of studies have been engaged investigating the impact of VDR expression in T cells and found that VDR expression and activity plays an important role in both T cell development, differentiation and effector function. In this review we will analyze current knowledge of VDR regulation and function in T cells and discuss its importance for immune activity." The vitamin D receptor and T cell function

VDR (Vitamin D Receptor) is a Protein Coding gene.

"...Vitamin D (VD) can be considered a functional steroid hormone with a well-established effect on musculoskeletal health. The purpose of this systematic review was to investigate the role of vitamin D in male reproduction, presenting current evidence from experimental animal and human studies. The basis of this interplay lays on the presence of Vitamin D-Receptor (VDR) and Vitamin D (VD) metabolizing enzymes in testis and male reproductive tract." Vitamin-D Deficiency and Male Reproduction

"The exact cause of multiple sclerosis (MS) remains elusive..." Vitamin D Supplementation in Central Nervous System Demyelinating Disease—Enough Is Enough

Useful links:

• Vitamin D Deficiency
• 8 Signs and Symptoms of Vitamin D Deficiency
• Link between cholesterol and vitamin D production identified
• VDR Gene (Protein Coding) Vitamin D Receptor
• Low Vitamin D Level Tied to Cognitive Decline
• Specific Changes in Vitamin D Receptor Protein Linked to MS Risk, Study Suggests
• The effect of vitamin D on sperm motility and the underlying mechanism
• Vitamin D Supplements Are Not Effective, And Could Be Dangerous, Studies Find

Disclaimer : All data posted on this web site is for informational purpose ONLY! Do not conduct any medical experiments on yourself, your family members or on your friends. And "Because vitamin D is a hormone, an endocrinologist is the best type of doctor to discuss your vitamin D levels with." https://www.hormone.org/your-health-and-hormones/glands-and-hormones-a-to-z/hormones/vitamin-d