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Small molecule self-assembly: Disease pathology to biomedical applications
Small molecule self-assembly: Disease pathology to biomedical applications
Metabolite Amyloid
Phenylalanine Self-assembly in Phenylketonuria
Phenylalanine Self-assembly in Phenylketonuria
Part of M.Tech Thesis (IIT Kanpur)
Low molecular weight hydrogelator
Fmoc-Phenylalanine Hydrogel
Fmoc-Phenylalanine Hydrogel
Metabolomics study of Huntington's disease model and discovery of aggregation inhibitors
Metabolomics study of Huntington's disease model and discovery of aggregation inhibitors
NMR Spectroscopy-based Metabolomics of Drosophila Model of Huntington’s Disease
NMR Spectroscopy-based Metabolomics of Drosophila Model of Huntington’s Disease
Part of PhD Thesis (IIT Kanpur)
Discovery of Calmidazolium Chloride and Arginine/Arginine ethyl ester as PolyQ/ Huntingtin exon1 Aggregation Inhibitor
Discovery of Calmidazolium Chloride and Arginine/Arginine ethyl ester as PolyQ/ Huntingtin exon1 Aggregation Inhibitor
Mol. Pharmaceutics 2018 /Indian patent 346555 (application no 1182/DEL/2015 "A DRUG SCREENING PROCESS AND A DRUG FORMULATION FOR HUNTINGTON’S DISEASE")
ACS Chem. Neurosci. 2019 / Indian patent application no 201611003335
Part of PhD Thesis (IIT Kanpur)
Tau protein phase separation and aggregation
Tau protein phase separation and aggregation
Zn-Tau LLPS
Zinc promotes liquid–liquid phase separation of tau protein
Zinc promotes liquid–liquid phase separation of tau protein
Postdoctoral work at Case Western Reserve University
Colloborative research
Colloborative research
Osmolytes modulate polyglutamine aggregation in a sequence dependent manner
Glycogen synthase protects neurons from cytotoxicity of mutant huntingtin by enhancing the autophagy flux
Biodegradable Nanoparticles Containing Mechanism Based Peptide Inhibitors Reduce Polyglutamine Aggregation in Cell Models and Alleviate Motor Symptoms in a Drosophila Model of Huntington’s Disease
Development of mechanism-based antibacterial synergy between Fmoc-phenylalanine hydrogel and aztreonam
A Drosophila model of oral peptide therapeutics for adult Intestinal Stem Cell tumors
Fluorescence correlation spectroscopy as a tool to investigate the directionality of proteolysis
A revised mechanism for (p)ppGpp synthesis by Rel proteins: The critical role of the 2’-OH of GTP
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