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against (used especially to indicate an action brought by one party against another in a court of law, or to denote competing teams or players in a sports contest): Smith versus Jones; Army versus Navy.

Graft-versus-host disease: part I. Pathogenesis and clinical manifestations of graft-versus-host disease

S Hymes and others

J Am Acad Dermatol. 2012, Volume 66, Issue 4, Page 515

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In this trial of board-certified cardiologists adjudicating clinical transthoracic echocardiographic exams, AI-guided initial evaluation of LVEF was found to be non-inferior and even superior to sonographer-guided initial evaluation. After blinded review of AI versus sonographer-guided LVEF assessment, cardiologists were less likely to substantially change the LVEF assessment for their final report with initial AI assessment. Furthermore, the AI-guided assessment took less time for cardiologists to overread and was more consistent with cardiologist assessment from the previous clinical report. Although not the first trial of AI technology in clinical cardiology21,22,23, to our knowledge, this study represents the first blinded implementation of a randomized trial in this space.

Notwithstanding tremendous interest in AI technologies, there have been few prospective trials evaluating their efficacy and effect on clinician assessments. Important clinical trials of AI technology have already shown the efficaciousness of AI in cardiology21,25; however, given the difficulty of blinding a diagnostic tool, previous trials are often open-label and compared with a placebo or no diagnostic assistance. Previous works have shown that there can be a Hawthorne effect when studying novel technologies such as AI systems26,27. By introducing blinding with an active comparator arm, studies can better distinguish between the effect of the AI technology itself versus the impact of being observed or the act of introducing an intervention. Current FDA-approved technologies for LVEF assessment were not prospectively evaluated with randomization and blinding16. By integrating AI into the reporting software, our study sought to minimize bias in assessing the effect size of AI intervention.

Cardiologists with board certification in echocardiography were assigned to read independent transthoracic echocardiogram studies randomized to initial assessment by AI versus sonographer. Imaging studies were initially acquired and interpreted clinically by a board-certified cardiologist between 1 June 2019 and 8 August 2019 at Cedars-Sinai Medical Center. Studies were randomly sampled within the time range without regard to patient identity, so that multiple studies from the same patient would be randomized and assessed independently. Sonographers were asked to use their standard clinical practice to annotate the left ventricle for either single-plane or biplane method-of-discs calculation of LVEF10. Studies were excluded from randomization if the sonographer was unable to quantify the LVEF owing to inadequate image quality.

B.H., S.C., J.Y.Z. and D.O. designed the clinical trial, study protocol and implementation of the AI model. B.H., G.D. and M.J. engineered technical design and clinical deployment. A.C.K., J.H.C., N.Y., C.P., T.S., J.E., N.A.B., J.W., K.J. and R.S. performed the blinded review of AI versus sonographer assessments. B.H., S.C., J.Y.Z. and D.O. wrote the manuscript with feedback from all authors.

Graft-versus-host disease (GVHD) occurs due to the presence of immunocompetent T lymphocytes in the graft attacking the immunodeficient recipient tissue due to histocompatibility differences within 100 days, causing tissue damage. This activity illustrates the evaluation and management of graft versus host disease and explains the role of the interprofessional team in managing patients with this condition.

Objectives:Review the pathophysiology of graft versus host disease.Outline the physical exam findings for the prompt diagnosis of graft versus host disease.Summarize the management considerations for patients with graft versus host disease.Describe the importance of improving care coordination amongst interprofessional team members to improve outcomes for patients affected by graft versus host disease.Access free multiple choice questions on this topic.

In the gastrointestinal tract, apoptosis of epithelial cells is the most important feature. Dilated crypts, crypt destruction, villus atrophy, neutrophilic infiltration can also be seen in small bowel specimens [11]. Liver biopsy shows dysmorphic small bile ducts with portal inflammation. Histopathological damage of the skin ranges from minimal vacuolization to separation of the dermis from the epidermis. Grades of skin graft-versus-host-disease are as follows (Figure 2): [12]

Some people mistakenly believe that most privacy debates pit the interests of businesses or government versus those of consumers, where businesses gain when consumers lose. However, this is simply wrong. Many types of organizations, from businesses to non-profits to government agencies, collect, use, and share personal data, and both the organization and the individual benefit from these exchanges. Organizations benefit by using data for purposes such as improving products and services, conducting medical research, delivering targeted online ads, mapping traffic congestion, improving education, etc. And individuals obtain benefits, such as discounts at the grocery store, access to free or low-cost online apps and services, and improvements in medical knowledge among their health care providers. The fact that someone with a device and a broadband connection can now easily make a video conference call to someone else around the world at no cost because of online advertising is a testament to the benefits that a robust data ecosystem brings.

In reality, privacy debates are better characterized as consumer versus consumer. Different individuals will value their privacy differently depending on their personal preferences. When policymakers enact strict laws and regulations on privacy, especially opt-in rules, the relatively small share of privacy-sensitive individuals gain at the expense of the rest of society by making it more difficult for organizations to collect and use data efficiently.

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False positive rates for the FIT-DNA test are higher than for FIT alone (13% versus 5%, respectively).6 With erroneous results in one out of seven positive multi-targeted stool tests, appropriate counseling regarding accuracy and dependability of screening methods must be given when discussing fecal test results or endoscopy results with patients.

For a practical example of the tradeoffs estimators and other considerations preconstruction professionals are making as they plan and design projects, look no further than the choice being made every day: copper versus aluminum wire. 2351a5e196