Research
Research Interests
Embedded System Design, Internet on Things, Lab-on-Chip, Microfluidic, Electrowetting-on-Dielectric (EWOD) Devices, MEMS
Current Research
Supervisor: Prof. K. Muralidhar and Prof. Sameer Khandekar (IIT, Kanpur)
Title: Closed EWOD-Based Low-Cost Portable medical diagnostic system with thermal cycling
Summary: A printed circuit board (PCB) based electro-wetting-on-dielectric (EWOD) medical diagnostic system is developed. The medical diagnostic system integrates closed EWOD devices for droplet actuation with heating and cooling thermal cycling. The medical diagnostic system is portable, cost-effective for DNA amplification and biomedical diagnostics involving droplet actuation, merging, and splitting jointly with thermal cycling. The PCB-based EWOD medical diagnostic system includes open-source software which is available to the end-user for further tuning the processing steps. The PCB-based EWOD medical diagnostic system allows to carry data analysis using an on-board computer. Internet-of-thing facilities of the system permit real-time data and image transfer to the patient and the doctor.
Ph.D. Thesis
Supervisor: Prof. Rajendra Patrikar (VNIT, Nagpur)
Title: Design and Fabrication of a Low-Cost Open EWOD Based Dynamic Sensing System
Summary: A simple and low-cost open EWOD based dynamic droplet sensing system has been designed and fabricated to measure the droplet parameters. The system has the capability of monitoring and controlling the droplet position by using electrical and optical methods. The droplet position is measured electrically by sensing the capacitance between the bottom electrode and top ground wire with a capacitance input range of ±8 pF and resolution of 24 bit. OpenCV libraries are used in the optical method for processing of droplet images. The printed circuit board (PCB) technology is used for the cost-effective open EWOD device fabrication. Because of its portability, automation, and low cost, the dynamic sensing system has the potential to be useful in many of the existing lab-on-chip (LOC) applications.
M.Tech. Thesis
Supervisor: Prof. Vishal Dhamgay (RRCAT, Indore) and Prof. Andrew Thomas (SGSITS, Indore)
Title: Development of Bio-MOEMS Using X-Ray Lithography
Summary: The advancement of MEMS and its integration with optics leads to a new technology called MOEMS which has wide application in the biomedical field. Microflow cytometry is one of the interesting phenomena of integration of both MEMS and optics into a single chip for the analysis of particles in fluid. we had fabricated the microfluidic system and design kinoform lens for developing the BIO-MOEMS. UV and X-ray lithography (RRCAT) technique has been used for the fabrication of microfluidic system (Microvalve, micropump, and micromixer). Magnetohydrodynamic and Hydrodynamic principle is demonstrated for actuation of micropump and microvalve respectively. For of microflow cytometry device, we designed an optical lens for wavelength 488 nm and 632 nm using R-Soft.
