Valdmanis Lab

Welcome to the Valdmanis Lab!

About the Lab

The Valdmanis lab's research focus is to identify pathogenic variants that cause or modify human disease, determine the mechanisms of action of these genes in disease pathogenesis and correct the variants through gene therapy approaches including RNA interference and genome editing.


Our lab focuses on the following research goals:

1. Identify novel genetic contributors to Amyotrophic Lateral Sclerosis and Alzheimer's disease, including tandem repeat expansions using long-read sequencing technology.

2. Develop gene therapy methods for safe and effective gene knockdown using recombinant adeno-associated viral vectors (AAVs) to target genes implicated in neurodegeneration.

3. Perform mechanistic characterization of the role of microRNAs including miR-122 and an imprinted cluster of microRNAs at the DLK1-DIO3 locus in the development of hepatocellular carcinoma.


Lab News

12/9/20: Paul and Meredith were invited to speak at PacBio Neuroscience Day.

10/27/20: Paul and Meredith gave talks at ASHG (American Society of Human Genetics), where Meredith was given a Trainee Award for Excellence in Human Genetics Research.

8/3/20: The lab's new paper on a large tandem repeat associated with ALS is published in the American Journal of Human Genetics!

7/23/20: Paul gives an interview on the latest research in the lab to Ann Arbor Active Against ALS.

7/20/20: Kristie Shirley joins the lab as a UW PREP student.

6/29/20: Paul receives a grant from the Royalty Research Fund!

3/02/20: Eleanore joins the lab as an undergraduate researcher.

2/28/20: Meredith receives a grant from the the Alzheimer's Disease Research Center!

1/10/20: Sam joins the lab as a graduate student.

12/19/19: Our research paper on shRNA-induced cardiotoxicity is published in Molecular Therapy-Nucleic Acids!

11/14/19: We are proud to have contributed to the Lieber lab's new paper, published in Cancer Research!

8/21/19: Our small RNA sequencing methods paper is published in JoVE!

6/24/19: Wendy Teuchler joins the lab for the summer as an NIH Maximizing Access to Research Careers (MARC) scholar.

5/5/19: The lab receives the Robert F. Schoeni Award for Research from Ann Arbor Active Against ALS (A2A3)!

5/1/19: Meredith gives a talk at ASGCT (American Society of Gene and Cell Therapy).

4/4/19: Alicia presents a poster at ACMG (American College of Medical Genetics).

4/1/19: Paul receives adjunct appointment in the Department of Pathology.

3/11/19: Congrats to the Jayadev lab on their new paper! We are proud to be part of that work.

12/13/18: Meredith receives the UW Office of Postdoctoral Affairs Travel Award.

11/2/18: Meredith gives an invited talk at The Personal Genome symposium.

10/16/18: Meredith presents a poster at ASHG (American Society of Human Genetics).

10/1/18: Sam Smukowski, a Genome Sciences PhD candidate, starts a rotation in the lab.

9/30/18: Meredith presents a poster at OTS (Oligonucleotide Therapeutics Society).

8/15/18: Paul becomes a member of the Molecular & Cellular Biology program at UW.

7/26/18: Paul has become an adjunct faculty member of UW Genome Sciences.

6/25/18: Alicia joins the lab for the summer as an MSRTP researcher.

5/1 6/18: Meredith presents a poster at ASGCT (American Society of Gene and Cell Therapy).

4/26/18: Meredith has a photo published in Nature's Science photos worth seeing.

3/26/18: Rev joins the lab as an undergraduate researcher.

3/16/18: Kosuke receives a Mary Gates Research Scholarship.

1/18/18: Paul receives a grant from the UW Alzheimer’s Disease Research Center.

12/12/17: Meredith receives a T32 training grant from the NIH/NIGMS.

11/8/17: Paul gives an invited talk for the Genome Sciences seminar series.

10/23/17: Meredith joins the lab as a postdoctoral fellow.

9/27/17: Bobby joins the lab as a student researcher.

9/18/17: Kosuke joins the lab as an undergraduate researcher.

8/1/17: The Valdmanis Lab officially opens!

6/1/17: Kathryn starts as a research scientist and lab manager, getting the lab ready to go.