Valdmanis Lab

Welcome to the Valdmanis Lab!


Sequence-based approaches to quantify effectiveness of viral gene therapy


Lab News

8/21/19: Our small RNA sequencing methods paper is published in JoVE!

6/24/19: Wendy Teuchler joins the lab for the summer as an NIH Maximizing Access to Research Careers (MARC) scholar.

5/5/19: The lab receives the Robert F. Schoeni Award for Research from Ann Arbor Active Against ALS (A2A3).

5/1/19: Meredith gives a talk at ASGCT (American Society of Gene and Cell Therapy).

4/4/19: Alicia presents a poster at ACMG (American College of Medical Genetics).

4/1/19: Paul receives adjunct appointment in the Department of Pathology.

3/11/19: Congrats to the Jayadev lab on their new paper! We are proud to be part of that work.

12/13/18: Meredith receives the UW Office of Postdoctoral Affairs Travel Award.

11/2/18: Meredith gives an invited talk at The Personal Genome symposium.

10/16/18: Meredith presents a poster at ASHG (American Society of Human Genetics).

10/1/18: Sam Smukowski, a Genome Sciences PhD candidate, starts a rotation in the lab.

9/30/18: Meredith presents a poster at OTS (Oligonucleotide Therapeutics Society).

8/15/18: Paul becomes a member of the Molecular & Cellular Biology program at UW.

7/26/18: Paul has become an adjunct faculty member of UW Genome Sciences.

6/25/18: Alicia joins the lab for the summer as an MSRTP researcher.

5/1 6/18: Meredith presents a poster at ASGCT (American Society of Gene and Cell Therapy).

4/26/18: Meredith has a photo published in Nature's Science photos worth seeing.

3/26/18: Rev joins the lab as an undergraduate researcher.

3/16/18: Kosuke receives a Mary Gates Research Scholarship.

1/18/18: Paul receives a grant from the UW Alzheimer’s Disease Research Center.

12/12/17: Meredith receives a T32 training grant from the NIH/NIGMS.

11/8/17: Paul gives an invited talk for the Genome Sciences seminar series.

10/23/17: Meredith joins the lab as a postdoctoral fellow.

9/27/17: Bobby joins the lab as a student researcher.

9/18/17: Kosuke joins the lab as an undergraduate researcher.

8/1/17: The Valdmanis Lab officially opens!

6/1/17: Kathryn starts as a research scientist and lab manager, getting the lab ready to go.

About the Lab

The Valdmanis lab's research focus is to develop small RNA technologies for safe and efficient gene therapy use. Small RNAs play a vital role in regulating gene expression and have been successfully engineered to target and repress disease-causing genes or infectious viruses.


We use cell culture and transgenic animal models to approach the following research aims:

1. Establish parameters for safe and effective gene knockdown using recombinant adeno- associated viral vectors (rAAV).

2. Identify the role of microRNAs in the development of hepatocellular carcinoma.

3. Ascertain the genetic basis of various neurodegenerative diseases.

4. Develop small hairpin RNAs (shRNAs) to target genes implicated in neurodegeneration.