Valdmanis Lab

Welcome to the Valdmanis Lab!


Sequence based approaches to quantify effectiveness of viral gene therapy

We are recruiting!

The Valdmanis lab's research focus is to develop small RNA technologies for safe and efficient gene therapy use. Small RNAs play a vital role in regulating gene expression and have been successfully engineered to target and repress disease-causing genes or infectious viruses.


We use cell culture and transgenic animal models to approach the following research aims:

1. Establish parameters for safe and effective gene knockdown using recombinant adeno- associated viral vectors (rAAV).

2. Identify the role of microRNAs in the development of hepatocellular carcinoma.

3. Ascertain the genetic basis of various neurodegenerative diseases.

4. Develop small hairpin RNAs (shRNAs) to target genes implicated in neurodegeneration.

The Valdmanis laboratory is part of the Division of Medical Genetics, in the Department of Medicine, University of Washington


Our laboratory is located on the 3rd floor of the J-wing of the Health Sciences Building, room J-305.