Valdmanis Lab

Welcome to the Valdmanis Lab!


Sequence based approaches to quantify effectiveness of viral gene therapy

Lab News

10/1/18 Sam Smukowski, a Genome Sciences PhD candidate starts a rotation in the lab.

7/26/18 Paul has become an adjunct faculty member of UW Genome Sciences.

6/25/18 Alicia joins the lab for the summer as an MSRTP researcher.

5/1 6/18 Meredith presents a poster at ASGCT.

4/26/18 Meredith has a photo published in Nature's Science photos worth seeing.

3/26/18 Rev joins the lab as an undergraduate researcher.

3/16/18 Kosuke receives a Mary Gates Research Scholarship.

1/18/18 Paul receives a grant from the UW Alzheimer’s Disease Research Center.

12/12/17 Meredith receives a T32 training grant from the NIH/NIGMS.

11/8/17 Paul gives an invited talk for the Genome Sciences seminar series.

10/23/17 Meredith joins the lab as a postdoctoral fellow.

9/27/17 Bobby joins the lab as a student researcher.

9/18/17 Kosuke joins the lab as an undergraduate researcher.

8/1/17 The Valdmanis Lab officially opens!

6/1/17 Kathryn starts as a research scientist and lab manager, getting the lab ready to go.

About the Lab

The Valdmanis lab's research focus is to develop small RNA technologies for safe and efficient gene therapy use. Small RNAs play a vital role in regulating gene expression and have been successfully engineered to target and repress disease-causing genes or infectious viruses.


We use cell culture and transgenic animal models to approach the following research aims:

1. Establish parameters for safe and effective gene knockdown using recombinant adeno- associated viral vectors (rAAV).

2. Identify the role of microRNAs in the development of hepatocellular carcinoma.

3. Ascertain the genetic basis of various neurodegenerative diseases.

4. Develop small hairpin RNAs (shRNAs) to target genes implicated in neurodegeneration.