Beginning Aug. 14, 2023, new Current Procedural Terminology (CPT) codes have been created that consolidate over 50 previous codes and greatly streamline the reporting of immunizations for the novel coronavirus (SARS-CoV-2, also known as COVID-19).

Beginning on Aug. 14, 2023, the CPT Editorial Panel approved the addition of new product codes 91318-91322 (91318 , 91319 , 91320 , 91321 , 91322) to identify monovalent vaccine product for immunization against COVID-19 (Pfizer, Moderna); retained existing Novavax Product Code 91304 for currently authorized vaccine product available for use in the U.S. and the updated (XBB.1.5) vaccine; deletion and/or revision of all other existing COVID codes (product and administration with associated guidelines and parenthetical note deletions/revisions); and addition of a single administration code (90480) for administration of new (i.e., 91318-91322) and existing (i.e., 91304) COVID-19 vaccine product.


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To facilitate immunization reporting, when applicable, the most recent new or revised immunization product codes, resulting from recent Panel actions, will be published according to the Category I Immunization Code Semi-Annual Early Release Schedule on July 1 and Jan. 1 in a given CPT cycle. However, an emergent/critical distribution and recommended administration of an immunization for immediate use may necessitate an additional "electronic" publication date for an immunization code apart from the established July 1 and Jan. 1 early release dates.

The immunization product codes approved for expedited/emergent release will be published with the implementation date identified and will warrant a shortened implementation period of three months or less, in agreement with the agreed upon date by all stakeholders, and predicated on the urgency of the situation (vs. the standard six-month implementation period).

Immunization product codes that are approved at the October Panel meeting are released for "electronic" publication the following Jan. 1. Immunization product codes that are approved at the February and May Panel meetings are released for publication on July 1 of each year. The full set of immunization codes, including those that have been approved in the annual production cycle, are included in the next CPT publication. Immunization product codes approved for expedited/emergent release will be available via electronic publication outside of the standard semiannual release schedule, as defined above.

When vaccines are provided as part of a well-child encounter, the ICD-10 guidelines instruct that code Z00.121 or Z00.129 (routine health check for child over 298 days old) includes immunizations appropriate to the patient's age. Code Z23 may be used as a secondary code if the vaccine is given as part of a preventive health care service, such as a well-child visit.ICD-10 for Combination Vaccines

When an evaluation and management service (other than a preventive medicine service) is provided on the same date as a prophylactic immunization, modifier -25 may be appended to the code for the evaluation and management service to indicate that this service was significant and separately identifiable from the physician's work of the vaccine counseling/administration.


Example: A patient presents for a visit to evaluate the control of his/her diabetes and at the same visit receives an influenza vaccine administration. A physician might report code 99213-25 with diagnosis code E11.9 in addition to the appropriate flu vaccine and administration codes.

Medicaid plans and private payers may require the inclusion of a vaccine product's National Drug Code (NDC) on your claim line for each vaccine product. This can be a bit confusing if the product is labeled with a 10-digit NDC, as HIPAA requires that NDC have 11-digits. To correctly report the NDC in the HIPPA format, you may have to translate the NDC.


The common format for submitting an NDC is a number that, if hyphenated, would appear in a 5-4-2 format. Some drug products are labeled in 4-4-2, 5-3-2, or 5-4-1 formats. To change these codes to the 11-digit format, a zero is placed within the product code to create the 5-4-2 format.

These codes are reported per vaccine/toxoid component. CPT defines a component for these purposes as each antigen in a vaccine that prevents disease(s) caused by one organism. Combination vaccines are those vaccines that contain multiple vaccine components.


You may report multiple units of code 90460 for each first vaccine/toxoid component administered. No modifier should be required when reporting multiple first components. Note also that code 90460 does not apply only to combination vaccines, but also to single component vaccines (such as influenza, human papilloma virus, or pneumococcal conjugate vaccines). This base code is reported for each vaccine administration to patients 18 years of age and under who receive counseling about the vaccine from a physician or qualified health care professional at the time of administration. Code 90461 is an add-on code reported for each additional vaccine component administered.

Report codes 90471-90474 for immunization administration of any vaccine that is not accompanied by face-to-face physician or other qualified health care professional counseling the patient and/or family, or for patients over 18 years of age.

An 11-year old girl presents for a preventive visit (99393). In addition, the child and her mother are counseled by the physician on risks and benefits of HPV (90649), Tdap (90715) and seasonal influenza (90660) vaccines. The physician documents the discussion. The mother signs consent to administration of these vaccines. A nurse prepares and administers each vaccine, completes chart documentation and vaccine registry entries, and verifies there is no immediate adverse reaction.

CMS and the American Medical Association (AMA) collaborated on a new approach to report use of COVID-19 vaccines. If you plan to administer the COVID-19 vaccines or COVID-19 monoclonal antibody products, especially if you plan to roster bill for codes that describe these services, download and install the newest release of PC-ACE (PDF). This release includes the coding structure for COVID-19 vaccine and monoclonal antibody products, currently comprised of both of these:

Together, these codes describe the administration of the COVID-19 vaccines and the monoclonal antibody products, as they become available. CMS and the AMA developed this code structure to make claims processing for administration of COVID-19 vaccines and monoclonal antibody infusions that get FDA EUA or FDA approval more efficient. Many of these codes are placeholders and aren't currently effective until an authorized product is specifically assigned. It's possible that we won't use all codes. We'll issue specific code descriptors in the future. Medicare effective dates for the codes will match with the date of the FDA EUA or FDA approval.

The CDC's National Center of Immunization and Respiratory Diseases (NCIRD) developed and maintains the CVX (vaccine administered) code set. The table below has the most up to date values. It includes both active and inactive vaccines available in the US. CVX codes for inactive vaccines allow transmission of historical immunization records. When a MVX (manufacturer) code is paired with a CVX (vaccine administered) code, the specific trade named vaccine may be indicated. These codes should be used for immunization messages using either HL7 Version 2.3.1 or HL7 Version 2.5.1. The version of the CVX code set for certification can be found on the archive page.

The Last Updated column indicates the last time this particular vaccine code was updated in this table.


Questions regarding this table should be directed to the IIS Technical Assistance Team(or use mailing address).

Note: Global Trade Identification Numbers (GTINs) are provided as a proxy indicator that the vaccine is 2D barcoded. We have recently learned that some of the GTINs in this table are inaccurate due to variations in the GTIN formats used by manufacturers. Specifically, some vaccine manufacturers are populating the first digit of the GTIN as a packaging level Indicator. Users are advised to use these GTIN values with caution until CDC can verify accuracy with the vaccine manufacturers.

Individuals should receive all recommended doses (including booster doses) to stay up to date with their COVID 19 vaccines. Visit the COVID-19 webpage to see when you are recommended to receive your next booster dose.

If you have applied to have your out of province vaccination(s) registered with your public health unit and are waiting to have them uploaded, you can call the Provincial Vaccine Contact Centre to book your next vaccine appointment if you fit the following criteria:

Lessons learnt from the 2009 (H1N1) flu pandemic highlighted factors limiting the capacity to collect European data on vaccine exposure, safety and effectiveness, including lack of rapid access to available data sources or expertise, difficulties to establish efficient interactions between multiple parties, lack of confidence between private and public sectors, concerns about possible or actual conflicts of interest (or perceptions thereof) and inadequate funding mechanisms. The Innovative Medicines Initiative's Accelerated Development of VAccine benefit-risk Collaboration in Europe (ADVANCE) consortium was established to create an efficient and sustainable infrastructure for rapid and integrated monitoring of post-approval benefit-risk of vaccines, including a code of conduct and governance principles for collaborative studies. The development of the code of conduct was guided by three core and common values (best science, strengthening public health, transparency) and a review of existing guidance and relevant published articles. The ADVANCE Code of Conduct includes 45 recommendations in 10 topics (Scientific integrity, Scientific independence, Transparency, Conflicts of interest, Study protocol, Study report, Publication, Subject privacy, Sharing of study data, Research contract). Each topic includes a definition, a set of recommendations and a list of additional reading. The concept of the study team is introduced as a key component of the ADVANCE Code of Conduct with a core set of roles and responsibilities. It is hoped that adoption of the ADVANCE Code of Conduct by all partners involved in a study will facilitate and speed-up its initiation, design, conduct and reporting. Adoption of the ADVANCE Code of Conduct should be stated in the study protocol, study report and publications and journal editors are encouraged to use it as an indication that good principles of public health, science and transparency were followed throughout the study. e24fc04721

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