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Structure, Function and Mechanism of ATP Synthase
Structure, Function and Mechanism of ATP Synthase
ATP synthase is the energy generator in cells. Its structure and function are similar to a hydroelectric generator as well. Proton gradient pushes the rotor complex to spin, and the torque leads to the conformational alternation to the catalytic sites. Our current research focuses to how mutants in the rotor/stator interface could affect the the energy coupling and transmission in this enzyme.
ATP synthase is the energy generator in cells. Its structure and function are similar to a hydroelectric generator as well. Proton gradient pushes the rotor complex to spin, and the torque leads to the conformational alternation to the catalytic sites. Our current research focuses to how mutants in the rotor/stator interface could affect the the energy coupling and transmission in this enzyme.
Human ATP synthase is also related to neuron degeneration, aging and cancer. We are interested to illustrate the roles of ATP synthase in the cell signaling pathways.
Human ATP synthase is also related to neuron degeneration, aging and cancer. We are interested to illustrate the roles of ATP synthase in the cell signaling pathways.
P-type ATPase: An Efflux Pump of Heavy Metal Ions
P-type ATPase: An Efflux Pump of Heavy Metal Ions
Ions are critical to all cells. Some ions are required abundantly and serve multiple biological functions; however, many of the heavy metal ions are toxic even at marginal concentration. P-type ATPases are ATP-powered ion transporters that are responsible to maintain the ion homoeostasis in both prokaryotes and eukaryotes.
Ions are critical to all cells. Some ions are required abundantly and serve multiple biological functions; however, many of the heavy metal ions are toxic even at marginal concentration. P-type ATPases are ATP-powered ion transporters that are responsible to maintain the ion homoeostasis in both prokaryotes and eukaryotes.
ZntA is the best-researched heavy metal P-type ATPase, translocating Zn2+/Pb2+/Cd2+ across the membrane. The goal of the project is to engineer a mutant to evaluate the nucleotide binding affinity by tryptophan fluorescence. The outcome of this study will elucidate the role of each tryptophan residue in ZntA and to facilitate further research on how cells can eliminate heavy metal ions under environmental stress.
ZntA is the best-researched heavy metal P-type ATPase, translocating Zn2+/Pb2+/Cd2+ across the membrane. The goal of the project is to engineer a mutant to evaluate the nucleotide binding affinity by tryptophan fluorescence. The outcome of this study will elucidate the role of each tryptophan residue in ZntA and to facilitate further research on how cells can eliminate heavy metal ions under environmental stress.
Algorithm Development for Data Processing and Automation
Algorithm Development for Data Processing and Automation
Chemistry and biochemistry research rely on tons of data. The combination of coding and chemistry enables automation of data processings. We develop algorithms to solve problems in glycomics, proteomics, bioinformatics and structural biology. This project aims to save valuable time and efforts from our doing repeated or time consuming jobs.
Chemistry and biochemistry research rely on tons of data. The combination of coding and chemistry enables automation of data processings. We develop algorithms to solve problems in glycomics, proteomics, bioinformatics and structural biology. This project aims to save valuable time and efforts from our doing repeated or time consuming jobs.
Working with coding languages is fun. Will you be able to solve the riddle shown on the left?
Working with coding languages is fun. Will you be able to solve the riddle shown on the left?
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