What is HumMod ?

HumMod: Modeling Human Physiology

HumMod (short for Human Model) is a comprehensive software platform for simulating integrative human physiology. Developed by Tom Coleman, Arthur Guyton, Robert Hester, and colleagues at the University of Mississippi Medical Center (UMMC), HumMod represents over 70 years of innovation in physiological modeling and its implementation on computational systems.

Originally derived from Guyton’s pioneering mathematical model of the cardiovascular system, HumMod has since grown into an extensive physiological simulation environment, incorporating dynamic models of over a dozen organs and systems — including cardiovascular, renal, respiratory, gastrointestinal and endocrine. 

The core of HumMod is a mathematical engine that solves thousands of coupled differential equations describing key homeostatic and pathological processes. These equations are implemented in a structured XML-based framework, which allows for transparency, extensibility, and cross-disciplinary collaboration.

Now in active development at the University of Toronto Scarborough (UTSc), the BIOC32 "Inclusive" version of HumMod introduces critical new dimensions of biological variability, including sex, age, and ethnicity. This ongoing work supports educational, clinical, and translational research goals — fostering a more inclusive approach to physiological simulation with undergraduates at the UTSc Computational Physiology Group. 

For more information on the story behind HumMod visit this link: HumMod | The origin of HumMod. 

In honour of Dr. Thomas George Coleman (1940 - 2021) ** https://doi.org/10.1161/HYPERTENSIONAHA.121.17287 **