Structural Biology Lab

Research interests

  • Proteins involved in human innate immune responses and signaling

  • Toll-like receptors (TLRs)

  • Adaptor proteins for TLR signaling (MyD88, TRAM, TIRAP, TRIF)

  • RIG-I, MDA5

  • ZAP

  • Mechanism of viral evasion of innate immune systems

    • HCV NS5A

    • Vaccinia virus A46

  • Bacterial proteins

    • Elongation factor P from Pseudomonas aeruginosa

    • Pseudomonas aeruginosa PA2196, TetR family transcriptional repressor

    • Bacillus subtilis HmoB, a heme oxygenase

  • Crystallization using gold nanoparticles by inducing crystal nucleation

    • Use of gold nano particles coated with NTA group for crystallization of his-tagged proteins

Applications