Insights

1. VENETOCLAX - mechanism of action- PAPER
   https://elearning.unicz.it/pluginfile.php/218997/mod_resource/content/1/Structures%20of%20BCL-2%20in%20complex%20with%20venetoclax%20Nature%202019.pdf
   Reference (the above paper):
   Birkinshaw, R.W., Gong, Jn., Luo, C.S. et al. Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. Nat Commun 10, 2385 (2019). https://doi.org/10.1038/s41467-019-10363-1
   
   

2. VENETOCLAX - and analogues molecules in Virtual Reality - VIDEO
   https://www.youtube.com/watch?v=wOLHLd0AQEQ
   Scientists analyze the structure of venetoclax in complex with BCL-2, a protein that regulates programmed cell death also known as apoptosis. Then, they look its interactions with the structure of a resistance mutant, G101V.

Reference (the above paper):
Birkinshaw, R.W., Gong, Jn., Luo, C.S. et al. Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. Nat Commun 10, 2385 (2019). https://doi.org/10.1038/s41467-019-10363-1