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Università "Magna Græcia" di Catanzaro
aa 2024/2025
Dear Students,
After the great success of previous years, we are excited to present the new edition of MedChemBlog! This year, we have introduced an important update: all insights from the medicinal chemistry courses are now gathered in a single page, making access to educational content faster and more organized.
Specifically, you will find in-depth discussions on topics covered in the following courses:
General Medicinal Chemistry (Faculty of Pharmacy)
Medicinal and Toxicological Chemistry I (Faculty of Pharmacy)
Molecular Pharmacology, Drug Development and Testing of Innovative Medicines (Faculty of Biotechnology)
Originally launched in 2020 during the pandemic, MedChemBlog has now become an essential educational tool. On this page, you will find all the topics discussed in class, enriched with information from key scientific databases such as Protein Data Bank, PubChem, and DrugBank.
Happy studying and best of luck!
_____________________________________________________________________________________
Carissimi studenti,
dopo il grande successo degli anni passati, siamo entusiasti di presentarvi la nuova edizione del MedChemBlog! Quest’anno abbiamo introdotto un’importante novità: tutti gli spunti relativi ai corsi di chimica farmaceutica sono ora raccolti in un’unica pagina, per garantirvi un accesso più rapido e organizzato ai contenuti didattici.
In particolare, troverete approfondimenti sugli argomenti trattati nei seguenti corsi:
Chimica Farmaceutica Generale (Facoltà di Farmacia)
Chimica Farmaceutica e Tossicologica I (Facoltà di Farmacia)
Farmacologia molecolare, Sviluppo e Testing di Farmaci Innovativi (Facoltà di Biotecnologie)
Il MedChemBlog, nato nel 2020 durante la pandemia, si è ormai consolidato come un prezioso strumento didattico. In questa pagina troverete tutti gli approfondimenti discussi a lezione, arricchiti da informazioni provenienti da database scientifici di riferimento come Protein Data Bank, PubChem e DrugBank.
Buona consultazione e buon lavoro!
Panzarella, G., Gualtieri, G., Romeo, I., & Alcaro, S. (2022). MedChemBlog: an innovative distance learning experience for teaching medicinal chemistry. Journal of Chemical Education, 100(1), 232-242
General Medicinal Chemistry
General Medicinal Chemistry
1 topic
Brief history of drug discovery and development
2 topic
Structural biology
3 topic
Development of new drugs
4 topic
Pharmacokinetics
5 topic
Prodrugs
MEDICINAL AND TOXICOLOGICAL Chemistry I
MEDICINAL AND TOXICOLOGICAL Chemistry I
1 topic
Topical anti-infective drugs
2 topic
Antibiotics
3 topic
Chemotherapeutic
and Antibacterial drugs
4 topic
Antimycobacterials
5 topic
Antifungal agents
6 topic
Antiprotozoal agents
7 topic
Antihelmintics
8 topic
Antiviral drugs
Influenza A M2 transmembrane domain bound to amantadine (PDB ID: 6BKK)
Crystal structure glutathione transferase Omega 3S from Trametes versicolor in complex with 2,4,4'-trihydroxybenzophenone (PDB ID: 6F68)
Crystal structure of glutathione transferase Omega 3S from Trametes versicolor in complex with 2,3,4-Trihydroxybenzophenone (PDB ID: 6F69)
Ergothioneine-biosynthetic methyltransferase EgtD in complex with pyrrolidinohistidine (PDB ID: 6FNT)
9 topic
Anticancers
Human estrogen receptor alpha ligand-binding domain in complex with 4-hydroxytamoxifen (PDB ID: 3ERT)
Estrogen receptor alpha ligand-binding domain complexed to estradiol (PDB ID:1A52)
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Raloxifene (PDB ID: 7KBS)
Crystal structure of T877A-AR-LBD (Hydroxyflutamide) (PDB ID: 4OGH)
Dihydrofolate reductase complexed with methotrexate, nmr, 21 structures (PDB ID: 1AO8)
Structure of Human HDAC2 in complex with SAHA (vorinostat) (PDB ID: 4LXZ)
Human uridine phosphorylase 1 (hUPP1) with 5-fluorouracil (PDB ID: 3NBQ)
Molecular Pharmacology, Development and Testing of Innovative Drugs
Molecular Pharmacology, Development and Testing of Innovative Drugs
1 topic
Essential chemistry for drug design
2 topic
Structural Biology
Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen (PDB ID: 5WB8)
Crystal structure of the human CDK12-cyclinK complex (PDB ID: 4UN0)
Crystal structure of chimeric avidin (PDB ID: 3MM0)
The structure of ompf porin in a tetragonal crystal form (PDB ID: 1OPF)
Blue variant of green fluorescent protein (PDB ID: 1BFP)
X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor (PDB ID: 7hvp)
3 topic
Drug design and development
NgCKK (N.Gruberi CKK) decorated 13pf taxol-GDP microtubule (PDB ID: 6QUY)
Three-dimensional structure of anti-ampicillin single chain Fv fragment complexed with the hapten (PDB ID: 1H8S)
Human dopamine D2 receptor in complex with spiperone (PDB ID: 7DFP)
DRD2 - D(2) dopamine receptor - Homo sapiens (Human) | UniProtKB | UniProt
Haloperidol: Uses, Interactions, Mechanism of Action DrugBank Online
Human sigma-1 receptor bound to haloperidol (PDB ID: 6DJZ)
Structure of Aspirin Acetylated Cyclooxygenase-1 in Complex with Diclofenac (PDB ID: 3N8Y)
Crystal structure of Diclofenac bound to the Cyclooxygenase active site of COX-2 (PDB ID: 1PXX)
Complex of the anti-hypertensive drug captopril an the human testicular angiotensin I-converting enzyme (PDB ID: 1UZF)
Crystal Structure of Human Angiotensin Converting Enzyme in complex with lisinopril (PDB ID: 1O86)
Cryo-EM structure of the baclofen/BHFF-bound human GABA(B) receptor in active state (PDB ID: 7C7Q)
Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state (PDB ID: 7C7S)
Influenza virus b/beijing/1/87 neuraminidase complexed with zanamivir (PDB ID: 1A4G)
4 topic
Pharmacodynamics
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