The Celtic Cocktail Trail highlights the best of Dublin dining and craft cocktails with an Irish twist. Enjoy a delicious beverage at each of these uniquely Dublin Celtic Cocktail destinations to redeem great prizes! Earn 300 points (3 stops) and redeem for a commemorative koozie. Earn 1,000 points (10 stops) and score an exclusive Celtic Cocktail Trail t-shirt!
Learn about this classic gin cocktail, which is a throwback from an era when airplanes were brand new and hospitality was paramount. Our Aviation cocktail is made with Larios, a vibrant and bright Mediterranean-style Gin. Classic flavors of cherry, lemon and violet are blended to create a flavorful and distinctive profile.
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Methodology/principal findings: In this study, an approach, named "Step-by-Step" (SBS), has been established. This method takes advantage of the occurrence of phage-resistant bacteria variants and ensures that phages lytic for wild-type strain and its phage-resistant variants are selected. A phage cocktail lytic for Klebsiella pneumoniae was established by the SBS method. This phage cocktail consisted of three phages (GH-K1, GH-K2 and GH-K3) which have different but overlapping host strains. Several phage-resistant variants of Klebsiella pneumoniae were isolated after different phages treatments. The virulence of these variants was much weaker [minimal lethal doses (MLD)>1.310(9) cfu/mouse] than that of wild-type K7 countpart (MLD = 2.510(3) cfu/mouse). Compared with any single phage, the phage cocktail significantly reduced the mutation frequency of Klebsiella pneumoniae and effectively rescued Klebsiella pneumoniae bacteremia in a murine K7 strain challenge model. The minimal protective dose (MPD) of the phage cocktail which was sufficient to protect bacteremic mice from lethal K7 infection was only 3.010(4) pfu, significantly smaller (p
Conclusions/significance: Our data showed that the phage cocktail was more effective in reducing bacterial mutation frequency and in the rescue of murine bacteremia than monophage suggesting that phage cocktail established by SBS method has great therapeutic potential for multidrug-resistant bacteria infection.
Nearly a decade ago, the Colorado Distillers Guild and the Colorado Bartenders Guild (along with co-sponsor Westword and MCA Denver) hosted the Colorado Cocktail Contest. The goal? To encourage the state's best mixologists to create a signature Centennial State cocktail. The competition was fierce, but Marnie Ward of Denver's now-closed Avenue Grill emerged victorious with the Tree Line, a cocktail made with Leopold Bros. whiskey and herbal liqueur. The recipe: 589ccfa754
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