Tyler Neurotechnology Lab





Transdermal Electrical Neuromodulation for Anxiety and Sleep Problems in High-Functioning Autism Spectrum Disorder: Feasibility and Preliminary Findings (2021). ST Foldes, AR Jensen, A Jacobson, S Vassall, E Foldes, A Guthery, D Brown, T Levine, WJ Tyler, and RE Frye. J Pers Med. 2021 Dec 6;11(12):1307. doi: 10.3390/jpm11121307

A double-blind pilot study of transcranial ultrasound (TUS) as a five-day intervention: TUS mitigates worry among depressed participants (2020). SJ Reznik, JL Sanguinetti, WJ Tyler, C Daft, JJB Allen. Neurology, Psychiatry and Brain Research 37, 60-6639. doi.org/10.1016/j.npbr.2020.06.004

Transcranial focused ultrasound to the right prefrontal cortex improves mood and alters functional connectivity in humans (2020). JL Sanguinetti, S. Hameroff, E.E. Smith, T. Sato, C.M.W. Daft, W.J. Tyler, J.J.B Allen. Frontiers in Human Neuroscience 14:52. doi: 10.3389/fnhum.2020.00052.

Transcranial electrical stimulation nomenclature. M. Bikson, Z. Esmaeilpour, D. Adair, G. Kronberg, W.J. Tyler, A. Antal, A. Datta, B.A. Sabel, M.A. Nitsche, C. Loo, D. Edwards, H. Ekhtiari, H. Knotkova, A.J. Woods, B.M. Hampstead, B.W. Badran, A.V. Peterchev (2019). Brain Stimulation, 12(6), 1349-1366. PMID: 31358456

Ultrasonic modulation of neural circuit activity. W.J. Tyler, Shane W. Lani, and Grace M. Hwang (2018). Current Opinion in Neurobiology 50, 222-231. doi.org/10.1016/j.conb.2018.04.011

Limited output transcranial electrical stimulation (LOTES-2017): Engineering principles, regulatory statutes, and industry standards for wellness, over-the-counter, or prescription devices with low risk. M. Bikson, B. Paneri, A. Mourdoukoutas, Z. Esmaeilpour, B.W. Badran, R. Azzam, D. Adair, A. Datta, X-H Fang, B. Wingeier, D. Chao, M. Alonso-Alonso, K. Lee, H. Knotkova, A.J. Woods, D. Hagedorn, D. Jeffery, J. Giordano, and W.J. Tyler (2018). Brain Stimulation 11 (1), 134-157. PMID: 29122535.

Deep-brain stimulation: No implant needed. Tyler, W.J. and A. Opitz (2017). Nature Biomedical Engineering 1, 632-633. doi: 10.1038/s41551-017-0120-y

Transcranial focused ultrasound: a new tool for non-invasive neuromodulation. Fini, M., and W.J. Tyler (2017). International Review of Psychiatry 29(2), 168-177. PMID: 28430535.

Multimodal Neural Interfaces for Augmenting Human Cognition. Tyler, W.J. (2017). In: Schmorrow D., Fidopiastis C. (eds) Augmented Cognition. Enhancing Cognition and Behavior in Complex Human Environments. AC 2017. Lecture Notes in Computer Science, vol 10285. Springer, Cham https://doi.org/10.1007/978-3-319-58625-0_29.

Non-invasive neural stimulation. Tyler, W.J., J.L. Sanguinetti, M. Fini, and N. Hool (2017). Proc. SPIE 10194, Micro- and Nanotechnology Sensors, Systems, and Applications IX, 101941L. doi: 10.1117/12.2263175.

Transdermal electrical neuromodulation of the trigeminal sensory nuclear complex improves sleep quality and mood. Boasso, A., H. Mortimore, R. Silva, L. Aven, and W.J. Tyler (2016). bioRxiv 043901; doi: http://dx.doi.org/10.1101/043901.

Tolerability of Repeated Application of Transcranial Electrical Stimulation with Limited Outputs to Healthy Subjects. Paneri, B., D. Adair, C. Thomas, N. Khadka, V. Patel, W. J. Tyler, L. Parra, M. Bikson (2016). Brain Stimulation 9(5), 740-54. PMID: 27372844

Transdermal neuromodulation of noradrenergic activity suppresses psychophysiological and biochemical stress responses in humans. Tyler, W.J., A. Boasso, H.M. Mortimore, R.S. Silva, J.D. Charlesworth, M.A. Marlin, K.A. Aebersold, L. Aven, D.Z. Wetmore, and S.K. Pal (2015). Scientific Reports 5, 13865, 1-17. PMID: 26353920

Is sham cTBS real cTBS? The effect on EEG dynamics. Opitz, A., W. Legon, J. Mueller, A. Barbour, W. Paulus, and W.J. Tyler (2015). Frontiers in Human Neuroscience 8, 1043. PMID: 25620925

Transcranial focused ultrasound modulates intrinsic and evoked EEG dynamics. Mueller, J., W. Legon, A. Opitz, T.F. Sato, W.J. Tyler (2014). Brain Stimulation 7(6), 900-908. PMID: 25265863

A quantitative overview of biophysical forces impinging on neural function. Mueller, J. and W.J. Tyler (2014). Physical Biology 11(5), 1-15. PMID: 25156965

Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans. Legon, W., T.F. Sato, A. Opitz, J. Mueller, A. Barbour, A. Williams, and W.J. Tyler (2014). Nature Neuroscience 17, 322-329. PMID: 24413698

Physiological observations validate finite element models for estimating subject-specific electric field distributions induced by transcranial magnetic stimulation of the human motor cortex. Optiz, A., W. Legon, A. Rowlands, W. Paulus, W. Bickel, and W.J. Tyler (2013). Neuroimage 81, 253-264. PMID: 23644000

The mechanobiology of brain function. Tyler, W.J. (2012). Nature Reviews Neuroscience 13(12), 867-878. PMID: 23165263

Pulsed ultrasound differentially stimulates somatosensory circuits in humans as indicated by EEG and fMRI. Legon, W., A. Rowlands, A. Opitz, T. Sato, and W.J. Tyler (2012). PLoS One 7(12), e51177. PMID: 23226567

Ultrasonic neuromodulation by brain stimulation with pulsed ultrasound. Tufail, Y., A. Yoshihiro, S. Pati, M. Li, W.J. Tyler (2011). Nature Protocols 6(9), 1453-1470. PMID: 21886108

Ultrasound for neuromodulation? A continuum mechanics hypothesis. Tyler, W.J. (2011). Neuroscientist 17(1), 25-36. PMID: 20103504

Transcranial pulsed ultrasound stimulates intact brain circuits. Tufail, Y., A. Matyushov, N. Baldwin, M.L. Tauchmann, J. Georges, A. Yoshihiro, S.I. Helms Tillery, W.J. Tyler (2010). Neuron 66(5), 681-694. PMID: 20547127

Noninvasive functional neurosurgery using ultrasound. Tyler, W.J., Y. Tufail, and S. Pati (2010). Nature Reviews Neurology 6(1), 13-14. PMID: 20057495

Remote excitation of neuronal circuits using low-intensity, low-frequency ultrasound. Tyler, W.J., Y. Tufail, M. Finsterwald, M.L. Tauchmann, E.J. Olsen, C. Majestic (2008). PLoS One 3(10) e3511. PMID: 18958151

Modulation of the regulatory activity of bacterial two-component Regulatory Systems by SlyA. Song, H, W. Kong, N. Weatherspoon, G. Qin, W. Tyler, J. Turk, R. Curtis III, Y. Shi (2008). Journal of Biological Chemistry 283 (42), 28158-28168. PMID: 18678876

Experience-dependent modification of primary sensory synapses in the mammalian olfactory bulb. Tyler, W.J., G. Petzold, S. Pal, and V. N. Murthy (2007). Journal of Neuroscience 27, 9427-9438. PMID: 17728456

Kinase activity is not required for alpha-CaMKII-dependent presynaptic plasticity at hippocampal CA3-CA1 synapses. Hojjati, M. R., G. M. van Woerden, W.J. Tyler, K. P. Giese, A. J. Silva, L. Pozzo-Miller, and Y. Elgersma (2007). Nature Neuroscience 10(9) 1125-1127. PMID: 17660813

BDNF increases release probability and the size of a rapidly recycling vesicle pool within hippocampal excitatory synapses. Tyler, W.J., X-l Zhang, K. Hartman, J. Winterer, W. Muller, P.K. Stanton, L. Pozzo-Miller (2006). Journal of Physiology 574 (3), 787-803. PMID: 16709633

Synaptic vesicle Recycling studied in transgenic mice expressing synaptopHluorin. Li, Z., J. Burrone, W.J. Tyler*, K.N. Hartman, D.F. Albeanu, V.N. Murthy (2005). Proceedings of the National Academy of Sciences 102 (17), 6131-6136 (*cover credit). PMID: 15837917

Synaptic vesicles. Tyler, W.J. and V. N. Murthy (2004). Current Biology 14(8), R294-297. PMID: 15084295

Miniature synaptic transmission and BDNF modulate dendritic spine growth and form in rat CA1 pyramidal neurones. Tyler, W.J., and L. D. Pozzo-Miller (2003). Journal of Physiology (London) 553(2), 497-509. PMID: 14500767

The role of neurotrophins in neurotransmitter release. Tyler, W.J., S. Perrett, and L. D. Pozzo-Miller (2002). Neuroscientist 8 (6), 524-531. PMID: 12467374

From acquisition to consolidation: On the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Tyler*, W.J., M. A. Alonso, C. R. Bramham, and L. D. Pozzo-Miller (2002). Learning and Memory 9 (5), 224-237 (*cover credit). PMID: 12359832

Protein synthesis-dependent and -independent regulation of hippocampal synapses by brain-derived neurotrophic factor. Tartaglia, N., J. Du, W.J. Tyler, E. Neale, L. D. Pozzo-Miller, and B. Lu (2001). Journal of Biological Chemistry 276 (40), 37585-37593. PMID: 11483592

Recombinant GABAc receptors expressed in rat hippocampal neurons after infection with an adenovirus containing the human gamma-1 subunit. Filippova, N., A. Sedelnikova, W.J. Tyler, T. L. Whitworth, H. Fortinberry, and D. S. Weiss (2001). Journal of Physiology (London) 535 (1), 145-153. PMID: 11507165

BDNF enhances quantal neurotransmitter release and increases the number of docked vesicles at the active zones of hippocampal excitatory synapses. Tyler, W.J., and L. D. Pozzo-Miller (2001). Journal of Neuroscience 21 (12), 4249-4258. PMID: 11404410

Celiac vagatomy reduces suppression of feeding by jejunal fatty acid infusions. Cox, J. E., W.J. Tyler, A. Randich, G. R. Kelm, and S. T. Meller (2001). Neuroreport 12 (6), 1093-1096. PMID: 11338171

Suppression of food Intake, body weight, and body fat by jejunal fatty acid infusions. Cox, J. E., W.J. Tyler, A. Randich, G. R. Kelm, S. S. Bharaj, R. J. Jandacek, and S. T. Meller (2000). American Journal of Physiology 278, R604-R610. PMID: 10712279

Responses of celiac and cervical vagal afferents to infusions of lipids in the jejunum or ileum of the rat. Randich, A., W.J. Tyler, J. E. Cox, S. T. Meller, G. R. Kelm, and S. S. Bharaj (2000). American Journal of Physiology 278, R34-R43. PMID: 10644619

Inhibition of sucrose intake by continuous celiac, superior mesenteric, and intravenous CCK-8 infusions. Cox, J. E., S. M. McCown, J. M. Bridges, and W.J. Tyler (1996). American Journal of Physiology 270, R319-R325. PMID: 8779861

Suppression ofsucrose intake by continuous near-celiac and intravenous cholecystokinin infusions in rats. Cox, J. E., G. S. Perdue, and W.J. Tyler (1995). American Journal of Physiology 268, R150-R155. PMID: 7840316


Machining Physiological Intelligence. Tyler, W.J. (2010). InQTel Quarterly, Vol 2: Issue 1, 33-37.


Tyler, W. J. (2018). Chapter 11 - Neuromechanobiology. In S. W. Verbruggen (Ed.), Mechanobiology in Health and Disease (pp. 327–348). Academic Press. https://doi.org/10.1016/B978-0-12-812952-4.00011-8

Neuromechanobiology of the brain: Mechanics of neuronal sturcture, function, and pathophysiology. Mueller, J. and W.J. Tyler. In Integrative Mechanobiology: Micro- and Nano- Techniques in Cell Mechanobiology, Y. Sun and D.H. Kim, Editors. 2015, Cambridge University Press: Cambridge, U.K. p. 347-368.