My lab explores how hematopoietic stem and progenitor cells (HSPC) form during development, how these cells function to maintain healthy hematopoiesis lifelong, and how dysfunction in them leads to hematologic malignancies.
Projects in the lab cover three main themes:
i) Defining regulators critical for de novo production of hematopoietic stem cells (HSCs) and HSC-independent progenitors during embryogenesis
ii) Deciphering how mutations found in human myelodysplastic syndromes (MDS) alter stem cell traits and influence differentiation choices
iii) Understanding how RNA and DNA binding proteins that are mutated in MDS affect R-loop structures in the nucleus