Research
Research
Embedded Files
2002-2008
2002-2008
Molecular mechanisms of cell migration and invasion
Molecular mechanisms of cell migration and invasion
Phosphoinositides and actin cytoskeleton cooperatively regulate cell migration and invasion by regulating protrusions called filopodia, lamellipodia , and podosomes/invadopodia.
Oikawa T, Yamaguchi H, Itoh T, Kato M, Ijuin T, Yamazaki D, Suetsugu S, Takenawa T.：PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nat Cell Biol, 6(5), 420-426, 2004
Oikawa T, Yamaguchi H, Itoh T, Kato M, Ijuin T, Yamazaki D, Suetsugu S, Takenawa T.：PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nat Cell Biol, 6(5), 420-426, 2004
Oikawa T, Itoh T, Takenawa T.：Sequential signals toward podosome formation in NIH-src cells. J Cell Biol, 182(1), 157-169, 2008
Oikawa T, Itoh T, Takenawa T.：Sequential signals toward podosome formation in NIH-src cells. J Cell Biol, 182(1), 157-169, 2008
2009-2012
2009-2012
Molecular mechanisms of cell-cell fusion
Molecular mechanisms of cell-cell fusion
Osteoclast fusion also involves molecular machineries that regulate cell invasion ー cell-cell fusion can be understood as cell invasion into another cell.
Oikawa T*, Oyama M, Kozuka-Hata H, Uehara S, Udagawa N, Saya H, Matsuo K.：Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion. J Cell Biol, 197(4), 553-568, 2012
Oikawa T*, Oyama M, Kozuka-Hata H, Uehara S, Udagawa N, Saya H, Matsuo K.：Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion. J Cell Biol, 197(4), 553-568, 2012
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2012-2013
2012-2013
Analysis of the osteoclast-cancer hybrid cells
Analysis of the osteoclast-cancer hybrid cells
Fusing with osteoclasts can instigate the epithelial-mesenchymal transition in cancer cells.
Oikawa T*, Nakamura A, Onishi N, Yamada T, Matsuo K, Saya H. : Acquired expression of NFATc1 downregulates E-cadherin and promotes cancer cell invasion. Cancer Res, 73(16), 5100-5109, 2013
Oikawa T*, Nakamura A, Onishi N, Yamada T, Matsuo K, Saya H. : Acquired expression of NFATc1 downregulates E-cadherin and promotes cancer cell invasion. Cancer Res, 73(16), 5100-5109, 2013
2013-2018
2013-2018
Molecular mechanisms of maintaining the epithelial cell integrity
Molecular mechanisms of maintaining the epithelial cell integrity
Some cancer cells undergo the epithelial-mesenchymal transition (EMT) while others do not. We found differences in the p53 function in the epigenetic regulation of certain epithelial gene loci.
Oikawa T, Otsuka Y, Onodera Y, Horikawa M, Handa H, Hashimoto S, Suzuki Y and Sabe H*. : Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity. Sci Rep, 8(1), 1595, 2018
Oikawa T, Otsuka Y, Onodera Y, Horikawa M, Handa H, Hashimoto S, Suzuki Y and Sabe H*. : Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity. Sci Rep, 8(1), 1595, 2018
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