PUBLICATIONS

Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques.

Lee BC, Gin A, Wu C, Singh K, Grice M, Mortlock R, Abraham D, Fan X, Zhou Y, Aljanahi A, Choi U, DeRavin SS, Shin TH, Hong SG, Dunbar CE.

Cell Stem Cell. 2024 Apr 4;31(4):455-466

Investigation of the impact of clonal hematopoiesis on severity and pathophysiology of COVID-19 in rhesus macaques.

Shin TH*, Zhou Y, Lee BC, Hong SG, Andrew SF, Flynn BJ, Gagne M, Todd J-PM, Moore IN, Cook A, Lewis MG, Foulds KE, Seder RA, Douek DC, Roederer M, Dunbar CE.

Front Vet Sci. 2023 Jul 6;10:1182197

A RUNX1-FPDMM rhesus macaque model reproduces the human phenotype and predicts challenges to curative gene therapies.

Lee BC, Zhou Y, Bresciani E, Ozkaya N, Dulau-Florea A, Carrington B, Shin TH, Baena V, Syed ZA, Hong SG, Zhen T, Calvo KR, Liu P, Dunbar CE.

Blood. 2023 Jan 19;141(3):231-237

A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions.

Shin TH, Zhou Y, Chen S, Cordes S, Grice MZ, Fan X, Lee BC, Aljanahi AA, Hong SG, Vaughan KL, Mattison JA, Kohama SG, Fabre MA, Uchida N, Demirci S, Corat MAF, Metais JY, Calvo KR, Buscarlet M, Natason H, McGraw KL, List AF, Busque L, Tisdale JF, Vassiliou GS, Yu KR, Dunbar CE.

Blood. 2022 Oct 20;140(16):1774-1789

Clonal hematopoiesis is not significantly associated with COVID-19 disease severity.

Zhou Y, Shalhoub R, Rogers SN, Yu S, Gu M, Fabre MA, Quiros PM, Shin TH, Diangson A, Deng W, Anand S, Lu W, Cullen M, Godfrey AL, Preller J, Hadjadj J, Jouanguy E, Cobat A, Abel L, Rieux-Laucat F, Terrier B, Fischer A, Novik L, Godron IJ, Strom L, Gaudinski MR, Lisco A, Sereti I, Gniadek TJ, Biondi A, Bonfanti P, Imberti L, Dalgard CL, Zhang Y, Dobbs K, Su HC, Notarangelo LD, Wu CO, Openshaw PJM, Semple MG, Mallat Z, Baillie K, Dunbar CE,  Vassiliou GS.

Blood. 2022 Oct 6;140(14):1650-1655

Mesenchymal stem cells target microglia via galectin-1 production to rescue aged mice from olfactory dysfunction.

Seo Y, Ahn JS, Shin YY, Oh SJ, Song MH, Kang MJ, Oh JM, Lee D, Kim YH, Lee BC, Shin TH*, Kim HS*.

Biomed Pharmacother. 2022 Sep;153:113347

Prediction and validation of hematopoietic stem and progenitor cell off-target editing in transplanted rhesus macaques.

AlJanahi AA, Lazzarotto CR, Chen S, Shin TH, Cordes S, Fan X, Jabara I, Zhou Y, Young DJ, Lee BC, Yu KR, Li Y, Toms B, Tunc I, Hong SG, Truitt LL, Klermund J, Andrieux G, Kim MY, Cathomen T, Gill S, Tsai SQ, Dunbar CE.

Molecular Therapy. 2022 Jan 5;30(1):209-222

Extracellular vesicles from SOD3-transduced stem cells exhibit improved immunomodulatory abilities in the murine dermatitis model.

Yang JS*, Seo Y*, Shin TH*, Ahn JS, Oh SJ, Shin YY, Kang MJ, Lee BC, Lee S, Kang KS, Hur J, Kim YS, Kim TY, Kim HS.

Antioxidants (Basel). 2020 Nov 23;9(11):1165

The activation of NLRP3 inflammasome potentiates the immunomodulatory abilities of mesenchymal stem cells in a murine colitis model.

Ahn JS, Seo Y, Oh SJ, Yang JW, Shin YY, Lee BC, Kang KS, Sung ES, Lee BJ, Mohammadpour H, Hur J, Shin TH*, Kim HS*.

BMB Rep. 2020 Jun;53(6):329-334

CRISPR/Cas9 PIG-A gene editing in nonhuman primate model demonstrates no intrinsic clonal expansion of PNH HSPCs.

Shin TH, Baek EJ, Corat MAF, Chen S, Metais JY, Aljanahi AA, Zhou Y, Donahue RE, Yu KR, Dunbar CE.

Blood. 2019 Jun 6;133(23):2542-2545

Genetic inactivation of CD33 in hematopoietic stem cells to enable CAR T cell immunotherapy for acute myeloid leukemia.

Kim MY, Yu KR, Kenderian SS, Ruella M, Chen S, Shin TH, Aljanahi AA, Schreeder D, Klichinsky M, Shestova O, Kozlowski MS, Cummins KD, Shan X, Shestov M, Bagg A, Morrissette JJD, Sekhri P, Lazzarotto CR, Calvo KR, Kuhns DB, Donahue RE, Behbehani GK, Tsai SQ, Dunbar CE, Gill S.

Cell. 2018 May 31;173(6):1439-1453.e19

The impact of aging on primate hematopoiesis as interrogated by clonal tracking.

Yu KR, Espinoza DA, Wu C, Truitt L, Shin TH, Chen S, Fan X, Yabe IM, Panch S, Hong SG, Koelle S, Lu R, Bonifacino A, Krouse A, Metzger M, Donahue RE, Dunbar CE.

Blood. 2018 Mar 15;131(11):1195-1205